Chemistry of Natural Compounds

, Volume 31, Issue 2, pp 214–220 | Cite as

Arenobufagin and gamabufotalin from the venom of the Central Asian green toadBufo viridis. Introduction, structural—functional features

  • M. S. Tashmukhamedov
  • Sh. Ya. Mirzaakhmedov
  • B. T. Ibragimov
  • F. G. Kamaev
  • K. M. Beketov
  • Z. A. Khushbaktova
  • Sh. I. Salikhova


Two bufodienolides have been isolated in the individual form from the Central Asian green toadBufo viridis for the first time. It has been established by1H NMR, mass spectrometry, and x-ray structural analysis that these compounds are gamabufotalin (3β, 11α, 14-trihydroxy-5β, 14ß-bufa-20,22-dienolide) and a crystalline modification of arenobufagin (3β, 11α, 14-trihydroxy-12-oxo-5β, 14β-bufa-20,22-dienolide). The biological activity of Bakagin — the total bufadienolides of the venom ofB. viridis, consisting predominantly of the compounds named — has been studied. The promising nature of a further study of Bakagin as a cardiotonic drug has been shown.


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • M. S. Tashmukhamedov
    • 1
  • Sh. Ya. Mirzaakhmedov
    • 1
  • B. T. Ibragimov
    • 1
  • F. G. Kamaev
    • 1
  • K. M. Beketov
    • 1
  • Z. A. Khushbaktova
    • 2
  • Sh. I. Salikhova
    • 1
  1. 1.A. S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkent
  2. 2.Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkent

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