Abstract
The acylation of 3-amino-4-cyano-1(2H)isoquinolines with benzoyl chloride leading to the formation of 1,3 oxazino[4,5-clisoquinoline-6-ones has been studied. Previously undescribed 1-aminopyrimido[4,5-cJisoquinolirt 6-ones have been obtained by the reaction of the appopriate 3-amino-](2H)isoginolones with formamide. Nucleophilic replacement has been carried out with 3-amino-1-chloroisoquinoline by the action of sodium hydroxide, primary alcohols, hydrazine hydrate, and various amines. 1,2,4-Triazino[2,3-b]isoginolone has been synthesized by condensing 2,3-diamino-1 (2H)isoquinolone with mesoxalic acid ethyl ester.
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T. Shevchenko Kiev University, Kiev 252017. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 515–520, April, 1994
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Volovenko, Y.M., Volovnenko, T.A., Babichev, F.S. et al. Conversions of polyfunctional 3-amino-1(2H)iso quinolines. Chem Heterocycl Compd 30, 453–457 (1994). https://doi.org/10.1007/BF01169941
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DOI: https://doi.org/10.1007/BF01169941