Abstract
A novel method has been developed for synthesizing N2-guanylcarboxylic acids by reaction of 2-chloro-7-benzyl-hypoxanthine with amino acids and debenzylation of the 7-benzyl-N2-guanylcarboxylic add products by means of palladium catalyzed hydrogenation.
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Additional information
Center for the Chemistry of Medicinal Compounds. All-Russian Chemico-Pharmaceutical Science Research Institute, Moscow 119815. State Institute for Blood Substitutes and Medicinal Preparations, Moscow 109044. Zaporozh'e State Medicinal Institute, Zaporozh'e 330074. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 395–398, March, 1996. Original article submitted January 17, 1996.
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Kochergin, P.M., Persanova, L.V. & Aleksandrova, E.V. Synthesis of n2-guanylcarboxylic acids. Chem Heterocycl Compd 32, 342–345 (1996). https://doi.org/10.1007/BF01169256
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DOI: https://doi.org/10.1007/BF01169256