Summary
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1.
The reaction between monoesters of phenylphosphonous acid, ketones or aldehydes, and ammonia has been studied. (1-Amino-1-methylethyl)-, (1-amino-1-methylpropyl)- (a-aminobenzyl)-, and (1-aminocyclohexyl)-phenylphosphinic acids have been prepared, and also the hydrochlorides of their ethyl esters.
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2.
With (1-amino-1-methylethyl)phenylphosphinic acid as working example, the structure of the synthesized compounds has been proved, (1-Amino-1-methylethyl)phenylphosphinic acid can be converted in the usual way into its acetyl derivatives, and treatment with nitrous acid converts it into the correspnding hydroxy acid.
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3.
A mechanism has been proposed for the reaction: it is considered that the alkyl hydrogen phenylphosphonite ionized under the influence of ammnia and its anion then adds to the carbonyl compound; this is followed by replacement of the hydroxy group by amino.
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V. S. Abramov, J. Gen. Chem., 22, 647 (1952). (T.p.709)
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Kabachnik, M.I., Medved, T.Y. New method for the synthesis of 1-aminoalkyl-phosphonic and phosphinic acids Communication 4. Synthesis of (1-aminoalkyl)phenylphosphinic acids. Russ Chem Bull 3, 893–900 (1954). https://doi.org/10.1007/BF01168173
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DOI: https://doi.org/10.1007/BF01168173