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Comparative analysis of the membrane-active properties of gossypol derivatives and their polymeric complexes

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Abstract

It has beeen shown that water-soluble complexes of gossypol derivatives obtained by their immobilization on polyvinylpyrrolidone posses a lower membrane activity than the initial substances. The degree of interaction of the substances under investigation with biomembranes has been determined from the change in the intensity of the flourescence of I-anilinonaphthalene-8-sulfonic acid (ANS).

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Authors and Affiliations

  1. Biology Faculty, Department of Biophysics, Tashkent State University, 700095, Tashkent, Vuzgorodok

    N. V. Gordienko, M. V. Zamaraeva & A. I. Gagel'gans

  2. A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent

    N. I. Baram, A. I. Ismailov, A. Biktimirov & Kh. L. Ziyaev

Authors
  1. N. V. Gordienko
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  2. M. V. Zamaraeva
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  3. A. I. Gagel'gans
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  4. N. I. Baram
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  5. A. I. Ismailov
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  6. A. Biktimirov
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  7. Kh. L. Ziyaev
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Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 375–381, May–June, 1995. Original article submitted October 14, 1994.

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Gordienko, N.V., Zamaraeva, M.V., Gagel'gans, A.I. et al. Comparative analysis of the membrane-active properties of gossypol derivatives and their polymeric complexes. Chem Nat Compd 31, 315–320 (1995). https://doi.org/10.1007/BF01165192

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  • DOI: https://doi.org/10.1007/BF01165192

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