Abstract
Unsubstituted imidazo[4, 5-c]pyridine does not react with chlorine, bromine, or iodine at room temperature or even upon heating to 160°C. The introduction of an oxo group activates the system such that halogenation proceeds readily. Imidazo[4, 5-c]pyridin-4-one gives 7-halo derivatives, while imidazo[4, 5-c]pyridin-2-ones give 4, 7-dihalo products.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1076—1081, August, 1994.
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Yutilov, Y.M., Svertilova, I.A. Halogenation of imidazo[4,5-c]pyridinones. Chem Heterocycl Compd 30, 928–933 (1994). https://doi.org/10.1007/BF01165031
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DOI: https://doi.org/10.1007/BF01165031