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2-Car-bethoxymethyl-4H-3,1-benzoxazin-4-one 6. Synthesis of some new 3-acylamino-4-oxaquinazolin-2-yl-acetic acid benzylamides as possible anticonvulsants

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Alternative ways of synthesizing 3-atizino-4-o.roquinazolin-2-yl-acetic and propionic acid benzy1amides and their aryl derivatives were investigated. The conditions of conversion of the synthesized 2-substituted 3-aminoquinazolin-4-ones into the corresponding 2-hydroxypyrazolo-3-R-(5,1-bjquinazolin-9(]H) -ones were determined.The findings of a study of the anticonvulsant properties of the synthesized compounds are reported.

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References

  1. I. V. UKrainets, V. A. Georgiyants, O. V. Gorokhova, P. A. Bezuglyi, N. G. Sergienko, and V. N. Savchenko, Ukr. Pharmaceutical Academy, Khar'kov (1993); submitted to UkrINTEI, No. 707-Uk 93 (03.30.93).

  2. P. A. Bezuglyi, I. V. Ukrainets, V. A. Georgiyants, V. I. Treskach, N. G. Sergienko, and V. N. Savchenko, Khar'kov State Pharmaceutical Institute, Khar'kov (1990); submitted to UkrNIINTI, No. 474-Uk 90 (03.13.90).

  3. P. A. Bezuglyi, V. A. Georgiyants, I. V. Ukrainets, O. V. Gorokhova, and V. I. Treskach, Khar'kov State Pharmaceutical Institute, Khar'kov (1992); submitted to UkrNIINTI, No. 261-Uk 92 (02.28.92).

  4. P. A. Bezuglyi, I. V. Ukrainets, V. A. Georgiyants, and O. V. Gorokhova, Khar'kov State Pharmaceutical Institute, Khar'kov (1990); submitted to UkrNIINTI, No. 1966-Uk 90 (12.05.90).

  5. R. S. Satoskar and S. D. Bandarkar, Pharmacology and Pharmacotherapy [in Russian], Meditsina, Moscow (1986).

    Google Scholar 

  6. M. J. Kornet, Eur. J. Med. Chem.,21, 529 (1986).

    Google Scholar 

  7. M. J. Kornet, T. Varia, and W. J. Beaven, Heterocycl. Chem.,20, 1553 (1983).

    Google Scholar 

  8. K. Kottke, H. Kuhmstedt, I. Grafe, and D. Knoke, Pharmazie,45, 528 (1990).

    Google Scholar 

  9. S. A. H. EI-Feky and Z. K. Abd EI-Samii, Arch. Pharm.,324, 381 (1991).

    Google Scholar 

  10. I. V. UKrainets, P. A. Bezuglyi, V. I. Treskach, A. I. Maslennikov, and S. V. Slobodzyan, USSR Inventor's Certificate No. 1,567,579; Byull. Izobr., No. 48 (1990).

  11. I. V. UKrainets, P. A. Bezuglyi, V. I. Treskach, A. V. Turov, S. V. Slobodzyan, and O. V. Gorokhova, Khim. Geterotsikl. Soedin., No. 8, 1128 (1991).

  12. P. A. Bezuglyi, I. V. Ukrainets, V. A. Georgiyants, V. I. Treskach, N. G. Sergienko, V. N. Savchenko, and A. V. Turov, Khar'kov State Pharmaceutical Institute, Kharkov (1990); submitted to UkrNIINTI, No. 1382-Uk 90 (08.21.90).

  13. P. A. Bezuglyi, I. V. Ukrainets, V. A. Georgiyants, V. I. Treskach, N. G. Sergienko, V. N. Savchenko, and A. V. Turov, Farm. Zh., No. 6, 35 (1990).

  14. I. V. UKrainets, V. A. Georgiyants, N. G. Sergienko, and V. N. Savchenko, Farm. Zh., No. 4, Part, 2, 65 (1991).

  15. S. K. Phadtare, S. K. Kamat, and G. T. Pause, Ind. J. Chem.,22B, 496 (1983).

    Google Scholar 

  16. I. V. UKrainets, P. A. Bezuglyi, V. I. Treskach, and S. V. Slobodzyan, Khim. Geterotsikl. Soedin., No. 8, 1123 (1991).

  17. A. F. Bochkov and V. A. Smlt, Organic Synthesis: Goals, Methods, Tactics, Strategy [in Russian], Nauka, Moscow (1987).

    Google Scholar 

  18. M. D. Mashkovskii, Drugs [in Russian], Vol. 1, Meditsina, Moscow (1988).

    Google Scholar 

  19. P. A. Bezuglyi, I. V. Ukrainets, V. I. Treskach, V. A. Georgiyants, and N. Yu. Bevz, Khar'kov State Pharmaceutical Institute, Khar'kov (1990); submitted to UkrNIINTI, No. 267-Uk 90 (02.19.90).

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Authors and Affiliations

  1. Ukrainian Pharmaceutical Academy, 310002, Khar'kov

    I. V. Ukrainets, O. V. Gorokhova, S. G. Taran, P. A. Bezuglyi & A. V. Turov

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  1. I. V. Ukrainets
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  2. O. V. Gorokhova
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  3. S. G. Taran
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  4. P. A. Bezuglyi
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  5. A. V. Turov
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 229–234, February, 1994. Original article submitted October 21, 1993.

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Ukrainets, I.V., Gorokhova, O.V., Taran, S.G. et al. 2-Car-bethoxymethyl-4H-3,1-benzoxazin-4-one 6. Synthesis of some new 3-acylamino-4-oxaquinazolin-2-yl-acetic acid benzylamides as possible anticonvulsants. Chem Heterocycl Compd 30, 208–212 (1994). https://doi.org/10.1007/BF01165014

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