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Crystal and molecular structure of reductiomycin

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Abstract

Conflicting results concerning the structure of the antitumor agent reductiomycin have been resolved. When the imino group and the heterocyclic oxygen atom of a previous x-ray study are interchanged, and this structure refined, it is found that: (i) a structure with satisfactory hydrogen bonding results, (ii) there are no unacceptably small nonbonded intermolecular distances, and (iii) agreement with two recent structure formulations based on various kinds of chemical and spectral evidence is achieved.

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Authors and Affiliations

  1. Department of Chemistry and Laboratory for Research on the Structure of Matter, University of Pennsylvania, 19104, Philadelphia, Pennsylvania

    Jerry Donohue, Amos B. Smith III & Patrick J. Carroll

Authors
  1. Jerry Donohue
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  2. Amos B. Smith III
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  3. Patrick J. Carroll
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Additional information

Camille and Henry Dreyfus Teacher Scholar, 1978–1983; National Institutes of Health (National Cancer Institute) Career Development Awardee, 1980–1985.

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Donohue, J., Smith, A.B. & Carroll, P.J. Crystal and molecular structure of reductiomycin. Journal of Crystallographic and Spectroscopic Research 14, 35–43 (1984). https://doi.org/10.1007/BF01161421

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  • DOI: https://doi.org/10.1007/BF01161421

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