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Crystal and molecular structures of 1-(2-iso butylylcarbamoyl propan-2-ylamino) 3-(1-naphthyloxy)propan-2-ol hydrochloride (1) (C21H31N2O3Cl) and 1-(2-isobutyloxycarbonylo propan-2-ylamino) 3-(1-naphthyloxy)propan-2-ol hydrochloride (2) (C21H30NO4Cl)

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Abstract

This paper shows the crystal structures of two newβ-adrenergic antagonists, derivatives of propranolol, which were determined with three-dimensional x-ray diffraction data. The space groups and unit-cell parameters are: compound1 (C21H31N2O3Cl) monoclinic space groupP21/c,a=20.523(4),b=6.909(2),c=15.950(2) Å,β=105.03(1)°; compound2 (C21H31NO4Cl) monoclinic space groupP21/c,a=6.364(2),b=36.043(8),c=10.149(1) Å,β=104.48(2)°. The structures were solved with direct methods, and refined with full-matrix least-squares techniques toR indices of 0.059 and 0.067, respectively. The-CH(OH)-CH2-NH-sections of the side chains show the conformation approximate togauche.

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Authors and Affiliations

  1. Institute of General Chemistry, Poland

    M. W. Wieczorek & G. D. Bujacz

  2. Institute of Technical Biochemistry, Poland

    E. Galas

  3. Institute of Organic Chemistry, Technical University of Łódź, Zwirki 36, 90-924, Łódź, Poland

    J. Zjawiony & A. Wojciechowska

Authors
  1. M. W. Wieczorek
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  2. G. D. Bujacz
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  3. E. Galas
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  4. J. Zjawiony
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  5. A. Wojciechowska
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Wieczorek, M.W., Bujacz, G.D., Galas, E. et al. Crystal and molecular structures of 1-(2-iso butylylcarbamoyl propan-2-ylamino) 3-(1-naphthyloxy)propan-2-ol hydrochloride (1) (C21H31N2O3Cl) and 1-(2-isobutyloxycarbonylo propan-2-ylamino) 3-(1-naphthyloxy)propan-2-ol hydrochloride (2) (C21H30NO4Cl). Journal of Crystallographic and Spectroscopic Research 19, 967–982 (1989). https://doi.org/10.1007/BF01160879

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