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Crystal and molecular structures of 1-(2-ethyloxycarbonylo propan-2-ylamino)-3-(1-napthyloxy) propan-2-ol-hydrochloride (1) (C19H26NO4Cl) and 1-(2-isopropyloxycarbonylo-propan-2-ylamino)-3-(1-napthyloxy) propan-2-ol hydrochloride (2) (C20H28N04Cl)

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Abstract

The crystal structures of two newβ-adrenergic antagonists, derivatives of propranolol, are shown in this paper. The space groups and unit-cell parameters are: compound1 (C19H26NO4Cl): triclinic, space groupP1,a=6.420(1),b=10.161(1),c=15.823(1) Å,α=82.47(1),β=84.16(1), γ=77.55(1)°; compound 2 (C20H28NO4Cl): monoclinic, space groupP21/c,a=6.460(1),b=33.285(2),c=10.120(1) Å,β=104.83(1)°. The structures were solved by direct methods and refined with full-matrix least-squares techniques toR indices of 0.055 and 0.048, respectively. The −CH(OH)-CH2-NH-sections of the side chains show the conformation approximate togauche.

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References

  • Ammon, H. L.,et al. (1977)Acta Cryst., B 33, 21.

    Google Scholar 

  • Cambridge Crystallographic Data Base (1989).

  • Frenz, B. A. (1984) SDP — Structure Determination Package (EnrafNonius, Delft).

    Google Scholar 

  • Sheldrick, G. M. (1986)Shelxs-86Program for Crystal Structure Determination (University of Gottingen, Gottingen).

    Google Scholar 

  • Valle, G.,et al. (1987)Liebiegs Ann. Chem. 1055.

  • Wieczorek, M. W.,et al., (1989a)J. Crystallogr. Spectroscop. Res. 19, 883.

    Google Scholar 

  • Wieczorek, M. W.,et al., (1989b)J. Crystallogr. Spectroscop. Res. 19, 967.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Technical Biochemistry, Technical University of Łódź, Stefanowskiego4/10, 90-924, Łódź, Poland

    G. D. Bujacz, M. W. Wieczorek & E. Galas

  2. Institute of Organic Chemistry, Technical University of Łódź, Poland

    J. Zjawiony & A. Wojciechowska

Authors
  1. G. D. Bujacz
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  2. M. W. Wieczorek
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  3. E. Galas
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  4. J. Zjawiony
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  5. A. Wojciechowska
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Bujacz, G.D., Wieczorek, M.W., Galas, E. et al. Crystal and molecular structures of 1-(2-ethyloxycarbonylo propan-2-ylamino)-3-(1-napthyloxy) propan-2-ol-hydrochloride (1) (C19H26NO4Cl) and 1-(2-isopropyloxycarbonylo-propan-2-ylamino)-3-(1-napthyloxy) propan-2-ol hydrochloride (2) (C20H28N04Cl). Journal of Crystallographic and Spectroscopic Research 21, 341–352 (1991). https://doi.org/10.1007/BF01156087

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  • DOI: https://doi.org/10.1007/BF01156087

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