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Voltage dependent sodium currents in cultured rat cerebellar granule cells

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Bioscience Reports

Abstract

Sodium currents were studied in granule cells dissociated from rat cerebellum. Macroscopic currents were recorded using the patch-clamp technique. Sudium currents, which are TTX sensitive, reached a maximum peak value of 0.42±0.08 pA/μm2 at 18.4±2.2 mV (n=6). Activation and inactivation kinetics and steady-state properties were described in terms of Hodgkin and Huxley, parameters. The properties of sodium channels in cultured rat cerebellar granule cells are very similar to those reported for various neural preparations.

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  1. Settore di Biofisica, Scuola Internazionale Superiore di Studi Avanzati, Strada Costiera 11, 1-34014, Trieste, Italy

    Fan Lin & Oscar Moran

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  1. Fan Lin
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  2. Oscar Moran
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Lin, F., Moran, O. Voltage dependent sodium currents in cultured rat cerebellar granule cells. Biosci Rep 10, 445–453 (1990). https://doi.org/10.1007/BF01152291

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  • DOI: https://doi.org/10.1007/BF01152291

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