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The assessment of particle friction of a drug substance and a drug carrier substance

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Abstract

The centrifuge technique, which has been previously used in adhesion experiments, has been modified for use in single particle friction studies. Both flat compacted surfaces and large single particles were used as substrate surfaces to allow assessment of drug-drug, drug-drug carrier and drug carrier-drug carrier friction forces. Particle size, particle shape and surface roughness were identified as main factors influencing the change from a static into a dynamic friction process and the division between friction due to adhesion and ploughing. The forces of adhesion and friction were found to be proportional to the reversible energy of adhesion. The ratio between the force of adhesion and the press-on force applied and the ratio between the force of friction and the press-on force can be related to the yield stress and the reduced Young's modulus of the materials in contact.

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Authors and Affiliations

  1. The School of Pharmacy, Department of Pharmaceutics, University of London, 29/39 Brunswick Square, WC1N 1AX, London, UK

    F. Podczeck & J. M. Newton

  2. Glaxo Research & Development Ltd, Park Road, SG12 0DP, Ware, Hertfordshire, UK

    M. B. James

Authors
  1. F. Podczeck
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  2. J. M. Newton
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  3. M. B. James
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Podczeck, F., Newton, J.M. & James, M.B. The assessment of particle friction of a drug substance and a drug carrier substance. J Mater Sci 30, 6083–6089 (1995). https://doi.org/10.1007/BF01151531

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  • DOI: https://doi.org/10.1007/BF01151531

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