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Tetracyclines modulate cytosolic Ca2+ responses in the osteoclast associated with “Ca2+ receptor” activation

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Abstract

We report the effects of tetracycline analogues on cytosolic Ca2+ transients resulting from application of ionic nickel (Ni2+), a potent surrogate agonist of the osteoclast Ca2+ “receptor”. Preincubation with minocycline (1 mg/l) or a chemically modified tetracycline, 4-dedimethyl-aminotetracycline (CMT-1) (1 or 10 mg/l), resulted in a significant attenuation of the magnitude of the cytosolic [Ca2+] response to an application of 5 mM-[Ni2+]. Preincubation with doxycycline (1 or 10 mg/l) failed to produce similar results. In addition, application of minocycline alone (0.1–100 mg/l) resulted in a 3.5-fold elevation of cytosolic [Ca2+]. The results suggest a novel action of tetracyclines on the osteoclast Ca2+ “receptor”.

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References

  1. Rifkin, B., Golub, L. M., Sanavi, F., Vernillo, A. T., Kleckner, A. P., McNamara, T. F., Auszmann, J. M. and Ramamurthy, N. S. (1992) In:Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. (Ed: Davidovitch, Z.) Ohio University College of Dentistry, Columbus. pp 85–90.

    Google Scholar 

  2. Gomes, B. C., Golub, L. M. and Ramamurthy, N. S. (1984)Experientia 40:1273–1275.

    Google Scholar 

  3. Golub, L. M., Ramamurthy, N. S., Kaneko, H., Sasaki, T., Rifkin, B. and McNamara, T. F. (1990)Res. Comm. Chem. Pathol. Pharmacol. 68:27–40.

    Google Scholar 

  4. Greenwald, R. A., Golub, L. M., Lavietes, B., Ramamurthy, N. S., Gruber, B., Laskin, R. S. and McNamara, T. F. (1987)J. Rheumatol. 14:28–31.

    Google Scholar 

  5. Greenwald, R. A., Simonson, B. G., Moak, S. A., Rush, S. W., Ramamurthy, N. S., Laskin, R. S. and Golub, L. M. (1988)J. Orthop. Res. 6:695–703.

    Google Scholar 

  6. Zaidi, M., Datta, H. K., Moonga, B. S., Patchell, A. and MacIntyre, I. (1989)Biochem. Biophys. Res. Commun. 163:1461–1465.

    Google Scholar 

  7. Malgaroli, A., Meldolesi, J., Zambonin-Zallone, A. and Teti, A. (1989)J. Biol. Chem. 264:14342–14347.

    Google Scholar 

  8. Zaidi, M., Kerby, J., Huang, C. L.-H., Alam, A. S. T., Rathod, H., Chambers, T. J. and Moonga, B. S. (1991)J. Cell. Physiol. 149:422–427.

    Google Scholar 

  9. Donahue, H. J., Ijima, K., Goligorsky, M. S., Rubin, C. T. and Rifkin, B. R. (1992)J. Bone Min. Res. 7:1313–1318.

    Google Scholar 

  10. Shankar, V. S., Bax, C. M. R., Alam, A. S. M. T., Bax, B. E., Huang, C. L.-H. and Zaidi, M. (1992)Biochem. Biophys. Res. Commun. 187:913–918.

    Google Scholar 

  11. Golub, L. M., Ramamurthy, N. S., McNamara, T. F., Greenwald, R. A. and Rifkin, B. R. (1991) Crit.Rev. Oral Biol. Med. 2:297–322.

    Google Scholar 

  12. Chambers, T. J. and Magnus, C. J. (1982)J. Pathol. 136:27–39.

    Google Scholar 

  13. Bax, C. M. R., Shankar, V. S., Moonga, B. S., Huang, C. L.-H. and Zaidi, M. (1992)Biochem. Biophys. Res. Commun. 183:619–625.

    Google Scholar 

  14. Martindale: (1989). The Extra Pharmacopoeia (29th edition). Pharmaceutical Press. London, p 264.

    Google Scholar 

  15. Zaidi, M., Datta, H. K., Moonga, B. S. and MacIntyre, I. (1990)J. Endocrinol. 125:473–481.

    Google Scholar 

  16. Moonga, B. S., Datta, H. K., Bevis, P. J. R., MacIntyre, I., Huang, C. L.-H. and Zaidi, M. (1991)Exp. Physiol. 76:923–933.

    Google Scholar 

  17. Zaidi, M., Datta, H. K. and MacIntyre, I. (1990)Biochem. Biophys. Res. Commun. 167:807–812.

    Google Scholar 

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Authors and Affiliations

  1. Division of Biochemical Medicine, St. George's Hospital Medical School, SW17 0RE, London, UK

    Christopher M. R. Bax, Vijai S. Shankar, A. S. M. Towhidul Alam, Bridget E. Bax, Baljit S. Moonga & Mone Zaidi

  2. Physiological Laboratory, Cambridge University, CB2 3EG, Cambridge, UK

    Christopher L. -H. Huang

  3. Department of Oral Medicine and Pathology, New York University, New York, New York, USA

    Barry R. Rifkin

Authors
  1. Christopher M. R. Bax
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  2. Vijai S. Shankar
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  3. A. S. M. Towhidul Alam
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  4. Bridget E. Bax
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  5. Baljit S. Moonga
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  6. Christopher L. -H. Huang
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  7. Mone Zaidi
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  8. Barry R. Rifkin
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Bax, C.M.R., Shankar, V.S., Towhidul Alam, A.S.M. et al. Tetracyclines modulate cytosolic Ca2+ responses in the osteoclast associated with “Ca2+ receptor” activation. Biosci Rep 13, 169–174 (1993). https://doi.org/10.1007/BF01149961

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  • DOI: https://doi.org/10.1007/BF01149961

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