Conclusions
-
1.
After administration of supraphysiological doses of hydrocortisone to rabbits, three periods are noted which characterize the functioning of the HACS. During period I absence of reactivity of the adrenal glands to ACTH develops against a background of normal basal content of corticosteroids in plasma, and response to a stressor is absent during the entire period. During period II the basal level of corticosteroids surpasses the control, the adrenal glands react to ACTH, but there is no response to a stressor. During period III all three parameters are normalized.
-
2.
Supraphysiological doses of hydrocortisone suppress reactivity of other structures of the HACS in addition to depression of reactivity of the adrenal glands. During development of disrupted HACS function, reactivity of adrenal glands is disengaged later, but is restored earlier than other links in the HACS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
M. A. Alekperov, Azerbaidzh. Med. Zh., No. 7, 66 (1963).
R. I. S. Bayliss, Br. Med. J.,2, 935 (1958).
G. Carreon, J. J. Canary, and L. H. Kyle, Clin. Res.,7, 146 (1959).
N. P. Christy, E. Z. Wallace, and J. W. Jailer, J. Clin. Endocr.,16, 1059 (1956).
C. G. Fraser, F. S. Preuss, W. D. Bigford, JAMA,149, 1542 (1952).
A. L. Graber, R. L. Ney, W. E. Nicholson, et al., J. Clin. Endocr.,25, 11 (1965).
D. A. Holub, J. W. Jailer, J. I. Kitay, et al., J. Clin. Endocr.,19, 1540 (1959).
J. W. Meakin, M. S. Tantongco, J. Grabbe, et al., Am. J. Med.,29, 459 (1960).
R. M. Salassa, W. A. Bennett, F. R. Keating, et al., JAMA,152, 1509 (1953).
I. I. Young, V. Fillips, F. L. Meyer, et al., Arch. Intern. Med.,100, 1 (1957).
S. A. Afinogenova, Probl. Éndocrinol., No. 4, 36 (1957).
N. A. Yudaev and S. A. Afinogenova, Probl. Endocrinol., No. 1, 19 (1960).
N. A. Yudaev and S. A. Afinogenova, Probl. Endocrinol., No. 2, 12 (1962).
J. C. Buckingham and J. R. Hodges, J. Endocr.,74, 297 (1977).
D. J. Ingle, Am. J. Physiol.,124, 369 (1938).
J. R. Hodges and S. Mitcheley, Br. J. Pharmacol.,40, 732 (1970).
D. A. Holub, J. I. Kitay, and J. W. Jailer, J. Clin. Invest.,38, 291 (1959).
J. Van der Vies, R. F. M. Bakker, and D. De Wied, Acta Endocr.,34, 513 (1960).
A. A. Filaretov, Neural Regulation of the Hypophyseal-Adrenocortical system [in Russian], Leningrad (1979).
Author information
Authors and Affiliations
Additional information
Translated from Problemy Éndokrinologii, Vol. 30, No. 4, pp. 56–59, July–August, 1984.
Rights and permissions
About this article
Cite this article
Filaretov, A.A., Bogdanov, A.I. Functions of the hypophyseal-adrenocortical system after application of supraphysiological doses of corticosteroids in rabbits. Neurosci Behav Physiol 16, 251–254 (1986). https://doi.org/10.1007/BF01149496
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01149496