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Paroxysmal changes in electrochemical activity of the cerebral cortex on platinum electrodes

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Conclusions

  1. 1.

    Under certain conditions, namely in the presence of negative values of electrode potential of between 5 and 15 mV, changes in potential which we call paroxysmal changes of bioelectrochemical potential developed on platinum electrodes implanted down to the brain surface in rabbits.

  2. 2.

    Paroxysmal changes in BECP had characteristic parameters: negative sign, rate of rise of the process much faster than its rate of fall, amplitude of between hundreds of microvolts and several millivolts, duration between seconds and several seconds, and high degree of localization (not exceeding 1.5–2 mm2).

  3. 3.

    Paroxysmal changes in BECP showed close correlation both with background periodic fluctuations of electrode potential arising only during fluctuations of electrode potential in the negative direction, and with sensory stimulation, being intensified in response to the presentation of various stimuli.

  4. 4.

    Simultaneous recording with platinum, gold, and nonpolarized electrodes from the same point on the brain surface revealed that paroxysmal changes in BECP are not the result purely of a change in redox potential of the medium surrounding the electrode, and they are not accompanied by bioelectrical processes.

  5. 5.

    It is suggested that under certain conditions, against the background of locally changed cortical metabolism, processes may develop in the brain tissue leading to release of portions of metabolites, specifically interacting with the platinum electrode and giving rise to paroxysmal changes in BECP into the extracellular medium and CSF above the cortical surface. It is suggested that these changes in BECP may have a bearing on some forms of seizure activity.

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow

    T. B. Shvets-Ténéta-Gurii

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  1. T. B. Shvets-Ténéta-Gurii
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 30, No. 5, pp. 1021–1029, September–October, 1980.

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Shvets-Ténéta-Gurii, T.B. Paroxysmal changes in electrochemical activity of the cerebral cortex on platinum electrodes. Neurosci Behav Physiol 13, 216–222 (1983). https://doi.org/10.1007/BF01148853

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  • DOI: https://doi.org/10.1007/BF01148853

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