Conclusions
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1.
Intrahippocampal injection of 5 μg serotonin into rats immediately after defensive conditioning leads to the development of retrograde amnesia. Injection of the same dose of serotonin inhibits incorporation of [3H]leucine into hippocampal proteins. An increase in the dose of serotonin injected to 10 μg has no effect on consolidation of conditioned reflexes once formed or on protein synthesis in the hippocampus.
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2.
Addition of serotonin to the incubation medium containing surviving hippocampal slices leads to a decrease in the incorporation of [14C]leucine and an increase in the incorporation of [3H]fucose into total proteins of the hippocampal slices. The most profound inhibition of incorporation of [14C]leucine into hippocampal proteins is observed by the action of maximal and minimal serotonin concentrations.
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3.
These results suggest that the participation of serotonin in the consolidation process is connected with its regulatory role in protein metabolism in the hippocampus.
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 30, No. 5, pp. 988–993, September–October, 1980.
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Getsova, V.M., York, R. & Wetzel, W. Mechanisms of serotonin involvement in conditioned reflex consolidation. Neurosci Behav Physiol 13, 197–201 (1983). https://doi.org/10.1007/BF01148850
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DOI: https://doi.org/10.1007/BF01148850