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Role of the medial hypothalamus in regulation of the pituitary-adrenocortical system

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Abstract

Chronic experiments on rabbits showed that bilateral electrolytic destruction of dorsomedial and ventromedial hypothalamic nuclei lowers the basal blood corticosteroid levels. Stimulation of the dorsal tegmentum, which in intact animals causes the blood corticosteroids to rise, no longer leads to an increase in the adrenocortical hormone level after destruction of these nuclei. It is concluded that the medial hypothalamus has a tonic activating influence on basal secretion and participates in transmission of activating influences from the midbrain to the adrenal cortex.

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Literature cited

  1. A. A. Filaretov, “Hypothalamic unit responses to impulses from the hippocampus and mesencephalic reticular formation,” Neirofiziologiya,6, No. 5, 489 (1974).

    Google Scholar 

  2. A. A. Filaretov, “influence of the mesencephalic reticular formation on the pituitary-adrenocortical system,” Fiziol. Zh. SSSR,60, No. 8, 1165 (1974).

    PubMed  Google Scholar 

  3. A. A. Filaretov, “Neurophysiological aspects of regulation of the pituitary-adrenocortical system,” in: The Pituitary-Adrenal System and the Brain [in Russian], Nauka, Leningrad (1976), pp. 24–48.

    Google Scholar 

  4. C. Bouille, S. Herbute, and J. D. Bayle, “Effect of hypothalamic deafferentation on basal and stress-induced adrenocortical activity in the pigeon,” J. Endocrinol.,66, No. 3, 413 (1975).

    PubMed  Google Scholar 

  5. S. A. D'Angelo, “Hypothalamus and endocrine function in persistent estrous rats at low environmental temperature,” Am. J. Physiol.,199, 701 (1960).

    PubMed  Google Scholar 

  6. R. H. Egdahl, “The effect of brain removal, decortication and midbrain transection on adrenal cortical function in dogs,” Acta Endocririol.,35, Suppl. 51, 49 (1960).

    Google Scholar 

  7. A. A. Filaretov, “Interrelationships of hypothalamic neurons in regulation of pituitary-adrenocortical system,” in: Symposium of the International Society of Psychoneuroendocrinologists, Visegrad (1975), Acad. Kiado, Budapest (1976), pp. 527–537.

    Google Scholar 

  8. B. Halasz, “Hypothalamic mechanisms controlling pituitary function,” in: Topics in Neuroendocrinology. Progress in Brain Research, Vol. 38, Elsevier, Amsterdam (1972), pp. 97–118.

    Google Scholar 

  9. R. W. Porter, “The central nervous system and stress-induced eosinopenia,” Recent Prog. Hormone Res.,10, No. 1, 1 (1954).

    Google Scholar 

  10. E. Tonutti, “Experiments zur Lokalisation der hypothalamischen Steuerung der ACTH-Sekretion,” Acta Neuroveg.,23, No. 1, 35 (1961).

    Google Scholar 

  11. J. van der Vies, R. F. M. Bekker, and D. De Wied, “Correlated Studies on plasma free corticosterone and on adrenal steroid formation rate in vitro,” Acta Endocrinol,34, 513 (1960).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Academym of Sciences of the USSR, Leningrad

    A. A. Filaretov & V. V. Rakitskaya

Authors
  1. A. A. Filaretov
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  2. V. V. Rakitskaya
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Translated from Fiziologicheskii Zhurnal SSSR, imeni I. M. Sechenova, Vol. 63, No. 10, pp. 1407–1410, October, 1977.

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Filaretov, A.A., Rakitskaya, V.V. Role of the medial hypothalamus in regulation of the pituitary-adrenocortical system. Neurosci Behav Physiol 10, 135–138 (1980). https://doi.org/10.1007/BF01148449

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  • DOI: https://doi.org/10.1007/BF01148449

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