Skip to main content
SpringerLink
Log in

Spatial-temporal organization of subcortical brain functions during immune responses

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

In the course of long-term experiments on rabbits, functional dynamics of subcortical structures were studied by recording background (DC) and evoked potentials (EP) during immune responses elicited to various antigens. During the first day of the immune response process to the different antigens, changes in hypothalamus functioning were similar and occurred with a latency of 9 to 31 min. Inductive and productive primary immune responses were accompanied by successive phasic changes in the functioning of a number of subcortical structures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. N. P. Bekhtereva, Neurophysiological Aspects of Human Psychology [in Russian], Meditsina, Leningrad (1974), p. 151.

    Google Scholar 

  2. G. R. Broun, “Functional characteristics of hypothalamic structures during experimental tuberculosis,” Dissertation, Leningrad (1972), p. 170.

  3. D. S. Gordon, V. E. Sergeeva, and N. N. Golubeva, “Activity and distribution of biogenic amines in the thymus and spleen after administration of iso- and heterogeneous erythrocytes,” Byull. éksp. Biol. Med.,86, No. 8, 245–248 (1978).

    Google Scholar 

  4. V. A. Ilyukhina, “Analysis of brain neurodynamics over a range of bioelectrical time-amplitude spectra. Part 1: Significance of slow processes in the study of structural- functional organization of subcortical brain formations,” Fiziol. Cheloveka,5, No. 3, 467–482 (1979).

    Google Scholar 

  5. V. M. Klitenko, “A study of hypothalamic neuronal mechanisms regulating immune reactions in the rabbit,” Dissertation, Leningrad (1972), p. 170.

  6. V. A. Konyshev, “Information transfer in systems regulating substance balance in the organism,” Usp. Fiziol. Nauk,11, No. 1, 100–119 (1980).

    Google Scholar 

  7. N. V. Medunitsin, V. I. Limvinoz, and A. M. Moroz, Mediators of Cell Immunity and Intercell Interactions [in Russian], Meditsina, Moscow (1980), p. 264.

    Google Scholar 

  8. E. Newsholme and C. Start, Regulation of Metabolism, Wiley (1973).

  9. R. V. Petrov, Immunoglobulin and Immunogenetics [in Russian], Meditsina, Moscow (1976), p. 336.

    Google Scholar 

  10. R. V. Petrov, R. A. Durinyan, A. M. Vasilenko, V. K. Remetnyak, A. A. Mikhailova, L. A. Zakharova, E. O. Bragin, and M. A. Kukushkin, “Endorphin properties of bone-marrow stimulator antibody producers,” Dokl. Akad. Nauk SSSR,265, No. 2, 501–503 (1982).

    Google Scholar 

  11. G. M. Poltavchenko, “The influence of antigen and adrenergic preparations on the functional state of immuno-competent cells,” in: Early Signs of Tissue Incompatibility [in Russian], Moscow (1979). p. 69.

  12. I. S. Repin and I. L. Kratskin, “An analysis of hypothalamic fever reaction mechanisms,” Fiziol. Zh., SSSR,53, No. 10, 1206–1211 (1967).

    Google Scholar 

  13. A. A. Filaretov, Nervous Regulation of the Hypophyseal-Adrenocortical System [in Russian], Nauka, Leningrad (1979), p. 143.

    Google Scholar 

  14. H. Besedovsky, E. Sorkin, D. Felix, and H. Haas, “Hypothalamic changes during the immune response,” Eur. J. Immunol., No. 7, 323–325 (1977).

    Google Scholar 

  15. R. Conant and W. Asnby, “Every good regulator of a system must be a model of that system,” Int. J. Syst. Sci.,1, No. 2, 89–97 (1970).

    Google Scholar 

  16. L. Lichtestein and C. Henney, “Adenylate cyclase-linked hormone receptors: an important mechanism for the immunoregulation of leucocytes,” Prog. Immunol.,2, 73–83 (1974).

    Google Scholar 

  17. P. Murphy, P. Simon, and W. Willoughby, “Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte-activating factors made by rabbits' alveolar macrophages,” J. Immunol.,124, No. 5, 2498–2501 (1980).

    Google Scholar 

  18. O. Plescia, I. Yamamoto, T. Shimamura, and C. Feit, “Early cellular events in the response of mice to sheep red blood cells reflected by changes in the spleen level of cyclic AMP,” Ann. N. Y. Acad. Sci.,249, 362–369 (1975).

    Google Scholar 

  19. J. Uhr, M. Finkelstein, and J. Bamann, “Antibody formation,” J. Exp. Med.,115, No. 3, 655–670 (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathological Physiology and General Pathology, Scientific-Research Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad

    V. A. Grigor'ev & V. M. Klimenko

Authors
  1. V. A. Grigor'ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. M. Klimenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 70, No. 2, pp. 221–230, February, 1984.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grigor'ev, V.A., Klimenko, V.M. Spatial-temporal organization of subcortical brain functions during immune responses. Neurosci Behav Physiol 16, 305–313 (1986). https://doi.org/10.1007/BF01148174

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01148174

Key words

Search

Navigation