Abstract
28 rats were studied. They were divided into four groups of 7 rats of each: one-day control animals (Group A), sevenday control animals (Group B), one-day nerve growth factor (NGF)-treated animals (Group C) and seven-day NGF-treated animals (Group D). In all animals, the right sciatic nerve was explored and completely transected using microscissors under a microscope. In NGF-treated animals, NGF (0.1 mg/kg NGF) was injected subcutaneously. In control animals, there was a statistically significant decrease in AChE activity in the proximal stump of the transected sciatic nerve at 7-day measurements (p < 0.05). In the NGF-treated groups, mean AChE activity in the proximal stump of the transected sciatic nerve was decreased at the 7-day measurement. AChE activity difference between control and NGF-treated groups, measured on the 7th day, are statistically significant (p < 0.01). These results demonstrate the effect of NGF on the cholinergic system.
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Baykal, S., Usul, H., Aliyacioglu, Y. et al. Effects of nerve growth factor on acetylcholinesterase activity of the proximal stump of the transected sciatic nerve. Neurosurg. Rev. 20, 124–127 (1997). https://doi.org/10.1007/BF01138196
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DOI: https://doi.org/10.1007/BF01138196