Skip to main content
SpringerLink
Log in

Multiple meningiomas of the central nervous system without the stigmata of neurofibromatosis. Clinical and therapeutic study

  • Published:
Neurosurgical Review Aims and scope Submit manuscript

Abstract

Multiple meningiomas are relatively rare tumors without known neurofibromatosis. In this paper, such eight cases of multiple meningiomas as described byCushing andEisenhardt are presented. Certain aspects of diagnosis and surgical management of this rare condition are discussed with particular emphasis on the importance of the distinction among multiple meningioma, meningiomatosis, or recurrences of these tumors. Fortunately, many of these patients tolerate multiple surgical interventions well, although the removal of these tumors in critical areas is a difficult problem. Thus, we think that it is important to examine and supervise all patients who have had a meningioma for a possible occurence of a second meningioma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bonnal J, JD Born, M Tremoult: Meningiomas multiples intracraniens. Neurochirurgie 25 (1979) 78–83

    PubMed  Google Scholar 

  2. Butti G, R Assieltti, R Casolone, P Paoletti: Multiple meningiomas: A clinial, surgical, and cytogenetic analysis. Surg Neurol 31 (1989) 255–260

    PubMed  Google Scholar 

  3. Çetinalp E, S Haciyakupoğlu, Y Tanyas, H Bağ-datoğlu, M Taşkin, C Yücesoy: Multipl menenjiomlar. Çkurova Üniv Tip Fak Dergisi 8 (1983) 250–255

    Google Scholar 

  4. Crouse SK, BO Berg: Intracranial meningiomas in childhood and adolescence. Neurology 22 (1972) 135–141

    PubMed  Google Scholar 

  5. Cushing H, L Eisenhardt Meningiomas: Their classification, regional behaviour, life history, and surgical end results. Charles C Thomas, Springfield Ill 1938

    Google Scholar 

  6. Deda H, E Arasil, C Dinçer, E Çakiroğlu: Multiple spinal cord meningiomas. Turkish Neurosurgery 2 (1991) 36–38

    Google Scholar 

  7. Distelmaier P, E Lins, T Kolberg: Multiple meningiomas. Neurochirurgia 19 (1976) 114–117

    PubMed  Google Scholar 

  8. Domenicucci M, A Santoro, DH D'Osvaldo, R Delfini, GP Cantore, B Guidetti: Multiple intracranial meningiomas. J Neurosurg 70 (1989) 41–44

    PubMed  Google Scholar 

  9. Eljamel MSM, PM Foy: Multiple meningiomas and their relation to neurofibromatosis. Surg Neurol 32 (1989) 131–136

    PubMed  Google Scholar 

  10. Frazier CH, BJ Alpers: Meningeal fibroblastomas of cerebrum: A clinicopathologic analysis of seventy-five cases. Arch Neurol Psychiatry 29 (1933) 935–989

    Google Scholar 

  11. Friedmann T: Progress toward human gene therapy. Science 244 (1989) 1275–1281

    PubMed  Google Scholar 

  12. Gokalp HZ, E Arasil, A Erdoğan, N Egemen, S Naderi: Multiple intracranial meningiomas. Neurochirurgia 35 (1992) 95–96

    PubMed  Google Scholar 

  13. Inagawa S, H Yamakawa, M Nishikawa: Triple primary brain tumors of different histological types: Case report. Surg Neurol 41 (1994) 52–55

    PubMed  Google Scholar 

  14. Kars Z, F Ergüngör, O Gürçay, B Onol: Multiple meningiomas involving the orbit and the cranial cavity. J Clin Neuro-ophthalmol 3 (1983) 119–122

    Google Scholar 

  15. Lekanne Deprez RH, NA Groen, D Louz, A Hagemeijer, E van Drunen, JW Koper, CJ Avezaat, D Bootsma, TH van der Kwast, EC Zwarthoff: Con stitutional DNA-level aberrations in chromosome 22 in a patient with multiple meningiomas [review]. Genes, Chromosomes & Cancer 9 (1994) 124–128

    Google Scholar 

  16. Levin P, SW Gross, LI Malis, AH Kirshenbaum, SA Hollin: Multiple intracranial meningiomas. Surg Gynecol Obstet 119 (1964) 1085–1090

    PubMed  Google Scholar 

  17. Lusins JO, H Nakagawa: Multiple meningiomas evaluated by computed tomography. Neurosurgery 9 (1981) 137–141

    PubMed  Google Scholar 

  18. Luyendijik W: Meningiomes multiples et meningiomatoses. Acta Neurochir 3 (1954) 263–274

    Google Scholar 

  19. Mufson JA, LM Davidoff: Multiple meningiomas. Report of two cases. J Neurosurg 1 (1944) 45–57

    Google Scholar 

  20. Nahser HC, W Grote, E Löhr, L Gerhard: Multiple meningiomas: Clinical and computer tomographic observations. Neuroradiology 21 (1981) 259–263

    PubMed  Google Scholar 

  21. Nakasu S, A Hirano, T Shimura, JF Liena: Incidental meningiomas in autopsy study. Surg Neurol 27 (1987) 319–322

    PubMed  Google Scholar 

  22. Namer IJ, MN Pamir, K Benli, S Saglam, A Erbengi: Spinal meningiomas. Neurochirurgia 30 (1987) 11–15

    PubMed  Google Scholar 

  23. Neurofibromatosis Conference Statement. National Institutes of Health Consensus Development Conference. Arch Neurol 45 (1988) 575–578

    Google Scholar 

  24. Pagni CA, S Canavero, A Cento: Multiple spinal meningiomas: Case report and review of the literature. Zentrbl Neurochir 51 (1990) 225–228

    Google Scholar 

  25. Palaoğlu S, F Gezen, Ş Ünlü, T Bilge, A Bedük, ON Akin: Multiple meningioma olgusu. GATA Bülteni 27 (1985) 783–787

    Google Scholar 

  26. Payne CS, AD Roses: The molecular genetic revolution: Its impact on clinical neurology. Arch Neurol 45 (1988) 1366–1376

    PubMed  Google Scholar 

  27. Petrella R, S Levine, PL Wilmot, KD Ashar, AC Casamassima, LR Shapiro: Multiple meningiomas in a patient with constitutional ring chromosome 22. Am J Med Genet 47 (1993) 184–186

    PubMed  Google Scholar 

  28. Pulst SM, GA Rouleau, C Marineau, P Fain, JP Sieb: Familial meningioma is not allelic to neurofibromatosis 2. Neurology 43 (1993) 2096–2098

    PubMed  Google Scholar 

  29. Seizinger BR, S de la Monte, L Atkins, JF Gusella, RL Martuza: Molecular genetic approach to human meningioma: Loss of genes on chromosome 22. Proc Natl Acad Sci USA 84 (1987) 5419–5423

    PubMed  Google Scholar 

  30. Sheehy JP, HA Crockard: Multiple meningiomas: a long-term review. J Neurosurg 59 (1983) 1–5

    PubMed  Google Scholar 

  31. Taren JA: Meningiomas. In:Kahn EA, EC Crosby, RC Schneider (eds): Correlative Neurosurgery Charles C Thomas, Springfield Ill 1969

    Google Scholar 

  32. Tönnis D: Die Meningiome. Acta Neurochir 13 (1965) 308–310

    Google Scholar 

  33. Turgut M, OE Özcan, S Sağlam: Central neurofibromatosis. Eur Neurol 31 (1991) 188–192

    PubMed  Google Scholar 

  34. Vestergaard E: Multiple intracranial meningiomas. Acta Psychiat Neurol (Kbh.) 19 (1944) 389–411

    Google Scholar 

  35. Waga S, M Matsuda, H Handa, M Matsushima, K Ando: Multiple meningiomas. Report of four cases. J Neurosurg 37 (1972) 348–351

    PubMed  Google Scholar 

  36. Wood NW, RW White, JW Kernohan: One hundred intracranial meningiomas found incidentally at necropsy. J Neuropathol Exp Neurol 16 (1957) 337–340

    PubMed  Google Scholar 

  37. Zervas N, A Shintani, B Kallar, R Berry: Multiple meningiomas occupying separate neuraxial compartments. Case report. J Neurosurg 33 (1970) 216–220

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Adrian Menderes University Medical Faculty, Aydin

    Mehmet Turgut

  2. Department of Neurosurgery, Hacettepe University Medical Faculty, Ankara, Turkey

    Selçuk Palaoğlu, Osman Ekin Özcan & Özdemir Gürçay

  3. Department of Radiology, Hacettepe University Medical Faculty, Ankara, Turkey

    Muzaffer Eryilmaz

  4. Meşrutiyet Mahallesi Gençlik Caddesi, 11. Sokak, No: 22/4, 09100, Aydin, Turkey

    Mehmet Turgut

Authors
  1. Mehmet Turgut
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Selçuk Palaoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Osman Ekin Özcan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Özdemir Gürçay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Muzaffer Eryilmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Turgut, M., Palaoğlu, S., Özcan, O.E. et al. Multiple meningiomas of the central nervous system without the stigmata of neurofibromatosis. Clinical and therapeutic study. Neurosurg. Rev. 20, 117–123 (1997). https://doi.org/10.1007/BF01138195

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01138195

Keywords

Search

Navigation