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Interaction of proteins of the adenylate cyclase complex: Area-limited mobility or movement along the whole membrane? Analysis with the application of the percolation theory

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Bioscience Reports

Abstract

Extraction of the ‘fluid‘ lipid fraction from rat reticulocyte plasma membranes by phospholipase/BSA treatment leads to a reduction in the percentage of β-adrenoreceptors complexed with the regulatory N-proteins and to a decrease of adenylate cyclase stimulation with a β-agonist. Analysis of the data obtained on the basis of the percolation theory suggests that proteins of the adenylate cyclase complex move along the whole membrane.

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References

  • Bligh EG & Dyer WJ (1959) Can. J. Biochem. Physiol.37, 911–916.

    Google Scholar 

  • Counis R & Mongongu S (1978) Anal. Biochem.84, 179–185.

    Google Scholar 

  • DeLean A, Stadel JM & Lefkowitz RJ (1980) J. Biol. Chem.255, 7108–7117.

    Google Scholar 

  • Feldman H, Rodbard D & Levin D (1972) Anal. Biochem.45, 530–556.

    Google Scholar 

  • de Gennes PG (1976) Recherche7, 919–927.

    Google Scholar 

  • Glenney JR Jr & Glenney P (1983) Cell34, 503–512.

    Google Scholar 

  • Hancock AA, DeLean A & Lefkowitz RJ (1979) Mol. Pharmacol.16, 1–9.

    Google Scholar 

  • Hanski E, Rimon G & Levitzki A (1979) Biochemistry18, 846–853.

    Google Scholar 

  • Himmelblau DM (1972) Applied Nonlinear Programming, McGraw-Hill Book Company, New York.

    Google Scholar 

  • Houslay MD, Warren GB, Birdsall NJM & Metcalfe JG (1975) FEBS Lett.51, 146–151.

    Google Scholar 

  • Hughes SM (1983) FEBS Lett.164, 1–8.

    Google Scholar 

  • Lad PM, Preston MS, Welton AF, Nielsen TB & Rodbell M (1979) Biochim. Biophys. Acta551, 368–381.

    Google Scholar 

  • Larner AC & Ross EM (1981) J. Biol. Chem.256, 9551–9557.

    Google Scholar 

  • Limbird LE (1981) Biochem. J.195, 1–13.

    Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL & Randall RJ (1951) J. Biol. Chem.193, 265–275.

    Google Scholar 

  • Peters R (1981) Cell Biol. Int. Rep.5, 733–760.

    Google Scholar 

  • Petit VA & Edidin M (1974) Science184, 1183–1185.

    Google Scholar 

  • Petitou M, Tuy F & Rosenfeld C (1978) Anal. Biochem.91, 350–353.

    Google Scholar 

  • Saxton M (1982) Biophys. J.39, 165–173.

    Google Scholar 

  • Stauffer D (1979) Phys. Rep.54, 1–74.

    Google Scholar 

  • Stengel D & Hanoune J (1981) J. Biol. Chem.256, 5394–5398.

    Google Scholar 

  • Swillens S (1982) J. Cyclic Nucl. Res.8, 71–82.

    Google Scholar 

  • Vistnes AI & Puskin JS (1981) Biochim. Biophys. Acta644, 244–250.

    Google Scholar 

  • Williams LT, Jarett L & Lefkowitz RJ (1976) J. Biol. Chem.251, 3096–3104.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biophysics, Biological Faculty, Moscow State University, 119899, Moscow, U.S.S.R.

    Alexander S. Sobolev, Andrey A. Rosenkranz & Alexander R. Kazarov

Authors
  1. Alexander S. Sobolev
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  2. Andrey A. Rosenkranz
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  3. Alexander R. Kazarov
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Sobolev, A.S., Rosenkranz, A.A. & Kazarov, A.R. Interaction of proteins of the adenylate cyclase complex: Area-limited mobility or movement along the whole membrane? Analysis with the application of the percolation theory. Biosci Rep 4, 897–902 (1984). https://doi.org/10.1007/BF01138172

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  • DOI: https://doi.org/10.1007/BF01138172

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