Abstract
Various benzimidazole compounds have been shown to be highly eIIective as inhibitors (up to 50% reduction of activity) in vitro of the helminth-specilic enzyme, fumarate reductase, ofAscaris suum. Anthelmintically active and inactive benzimidazoles were similarly effective as inhibitors of enzyme activity. Albendazole-induced inhibition of Iumarate reductase was not observed when the enzyme was preincubated with NADH.
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Barrowman, M.M., Marriner, S.E. & Bogan, J.A. The fumarate reductase system as a site of anthelmintic attack inAscaris suum . Biosci Rep 4, 879–883 (1984). https://doi.org/10.1007/BF01138170
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DOI: https://doi.org/10.1007/BF01138170