Summary
-
1.
A study was made of the possibilities of applying cyclohexyloxycarbonyl protection of the amino group in peptide synthesis.
-
2.
A series of peptides, including the hexapeptide glycyl-L-prolyl-L-alanyl-glycyl-L-propyl-L-alanine, was synthesized.
-
3.
It was shown that hexa- and tri-peptides can be separated on Sephadex G-25.
-
4.
A discussion is given of some aspects of the acidolytic elimination of ester groupings and protections of the urethan type from amino acids and peptides with the aid of HBr in CH3COOH.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
K. T. Poroshin, V. A. Shibnev, V. G. Debabov, and T. D. Kozarenko, Biokhimiya25, No. 4, 693 (1960).
T. C. McKay and N. F. Albertson, J. Amer. Chem. Soc.79, 4686 (1957).
Y. T. Young, Collect. Czechosl. chem. commun.24, 39 (1959).
N. A. Izmailov, Electrochemistry of Solutions [in Russian], Izd. Khar'kovskogo univ., p. 547 (1959).
K. T. Poroshin, V. G. Debabov, and V. I. Maksimov, Izv. AN SSSR. Otd. khim. n. 1134 (1961).
Ben-Yshai, J. Organ. Chem.19, 62 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Debabov, V.G., Shibnev, V.A. Cyclohexyloxycarbonyl group in the synthesis of prolyl-containing peptides. Russ Chem Bull 12, 785–790 (1963). https://doi.org/10.1007/BF01134725
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01134725