Summary
In 16 women undergoing IVF-ET, with more than four embryos available, two transfers were performed (24 hr apart), instead of one. The pregnancy rate was 25%, as compared with a pregnancy rate of 6.2% in 16 women having fewer than four embryos available and in whom one conventional transfer was performed.
Since in our IVF-ET program, we do not freeze the extra embryos available, the purpose of the double transfer was to use all the embryos available and to improve the chances of finding the “implantation window” open.
It is our feeling that multiple transfers may be beneficial to improve the pregnancy rate in an IVF-ET program without freezing facilities. However, a larger controlled clinical trial is necessary, in order to establish the advantages of multiple transfers in terms of pregnancy rate in comparison with the protential disadvantages.
This is a preview of subscription content, log in via an institution to check access.
References
Steptoe PC, Edwards RG: Birth after the reimplantation of a human embryo. Lancet 1978;2:365
Seppala M, Julkunen M, Rutanen EM, Huhtala ML: Proteins of the human endometrium: Basic studies toward a blood test for endometrial function. Abstracts of the Fifth World Congress on in Vitro Fertilization and Embryo Transfer, Norfolk, VA, 1987, p 16
Edwards RG: Uterine endocrinology. Abstracts of the Fifth World Congress on in Vitro Fertilization and Embryo Transfer, Norfolk, VA, 1987, p 17
Frydman R, Forman R, Rainhorn JD, Belaisch-Allart J, Hazout A, Testart J: A new approach to follicular stimulation for in vitro fertilization: Programmed oocyte retrieval. Fertil Steril 1986;46:667–671
Meshiach S: Protocols for induction of ovulation: The concept of programmed cycles. Abstract of the Fifth World Congress on in Vitro Fertilization and Embryo Transfer, Norfolk, VA, 1987, p 2
Dirnfeld M, Lejeune B, Camus M, Vekamans M, Leroy F: Growth rate of follicular estrogen secretion in relation to the outcome of in vitro fertilization and embryo replacement. Fertil Steril 1985;43:375–383
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abramovici, H., Dirnfeld, M., Weisman, Z. et al. Pregnancies following the interval double-transfer technique in an in vitro fertilization-embryo transfer program. J Assist Reprod Genet 5, 175–176 (1988). https://doi.org/10.1007/BF01131183
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01131183