Abstract
Most ovum donation (OD) programs involve cycle synchronization between recipient and donor for normally cycling recipients and a complex estrogen-progesterone replacement regimen for recipients with ovarian failure. In 1987, Serhal and Craft (1) suggested the use of a fixeddose estrogen-progesterone regimen for recipients who were normally ovulatory and to those with ovarian failure. Following this protocol, and simplifying it still, the authors administered 6 mg estradiol valerate (E2) daily orally starting on day 2–6 of induced withdrawal bleeding, augmented with 100 mg progesterone in ethyl oleate (P) intramuscularly daily, starting any time between 4 days prior to and the day of oocyte pickup. All recipients underwent embryo transfer at a 2-pronuclei (2PN)-10-cell stage. A group of 21 patients underwent 26 treatment cycles, resulting in 16 pregnancies. Twelve of the patients gave birth, one to triplets, two to twins, and nine to singletons. Four patients miscarried in the first trimester of pregnancy.
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Serhal PF, Craft IL: Ovum donation—a simplified approach. Fertil Steril 1987;48:265
Trounson A, Leeton J, Besanko M, Wood C, Conti A: Pregnancy established in an infertile patient after transfer of a donated embryo fertilized in vitro. Br Med J 1983;286:835
Lutjen P, Trounson A, Leeton J, Findlay J, Wood C, Renou P: The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primany ovarian failure. Nature 1984;307:174
Feichtinger W, Kemeter P: Pregnancy after total ovariectomy achieved by ovum donation. Lancet 1985;2:722
Navot D, Laufer N, Kopolovic J, Rabinowitz R, Birkenfeld A, Lewin A, Granat A, Margalioth EJ, Schenker JC: Artificially induced endometrial cycles and establishing of pregnancies in the absence of ovaries. N Engl J Med 1986;314:13
Rosenwaks Z, Veeck L, Liu H: Pregnancy following transfer of in vitro fertilized donated oocytes. Fertil Steril 1986;45: 417
Kogosowski A, Luxsman D, Amit A, Lessing JB, Yovel I, Bark Y, Ber A, Peyser MR, David MP: Prevention of premature luteinization with a short-term GnRH analog treatment in an IVF program using HMG/HCG stimulation regimen. Binational meeting of Germany/Israel, Jerusalem, Israel, 1988, p 34
Kogosowski A, Lessing JB, Amit A, Rudick V, Peyser MR, David MP: Epidural block: A preferred method of anesthesia for ultrasonically guided oocyte retrieval. Fertil Steril 1987;47:166
Barak Y, Lessing JB, Amit A, Kogosowski A, Yovel I, David MP, Peyser MR: The development of an efficient ambulatory in vitro fertilization (IVF) and embryo transfer (ET) program using ultrasonically guided oocyte retrieval. Acta Obstet Gynecol Scand 1988;67:1
Navot D, Anderson TL, Droesch K, Scott RT, Kreiner D, Rosenwaks Z: Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab 1989;68:801
Asch RH, Balmaceda JP, Ord T, Borrero C, Cefalu E, Gastaldi C, Rojas F: Oocyte donation and gamete intrafallopian transfer in premature ovarian failure. Fertil Steril 1988;49:263
Csapo AI, Pulkkinen M: Indispensability of the human corpus luteum in the maintenance of early pregnancy, lutectomy evidence. Obstet Gynecol Surv 1978;32:2
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Kogosowski, A., Yovel, I., Lessing, J.B. et al. The establishment of an ovum donation program using a simple fixed-dose estrogen-progesterone replacement regimen. J Assist Reprod Genet 7, 244–248 (1990). https://doi.org/10.1007/BF01129527
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DOI: https://doi.org/10.1007/BF01129527