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Methylglyoxal inhibits the translation of natural and chemically decapped mRNAs

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Bioscience Reports

Abstract

Methylglyoxal was a weak inhibitor of translation in the reticulocyte-lysate cell-free system and it did not display cap-dependent inhibition. A similar inhibition was obtained in a wheat-germ cell-free system that displayed extensive cap-dependent inhibition with the cap analogue 7-methylguanosine phosphate. These results show that the chemical reaction of methyl-glyoxat with 7-methylguanosine is not the mechanism for the inhibition of protein synthesis by methylglyoxal and that methylglyoxat is a weak general inhibitor of translation.

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Authors and Affiliations

  1. Department of Biochemistry, Health Sciences Centre, University of Ottawa, K1H 8M5, Ottawa, Ont., Canada

    Andres M. Lozano & Vasek A. Mezl

Authors
  1. Andres M. Lozano
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  2. Vasek A. Mezl
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Lozano, A.M., Mezl, V.A. Methylglyoxal inhibits the translation of natural and chemically decapped mRNAs. Biosci Rep 4, 783–788 (1984). https://doi.org/10.1007/BF01128820

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  • DOI: https://doi.org/10.1007/BF01128820

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