Skip to main content
SpringerLink
Log in

Quantitation of excretion of dolichol and dolichyl phosphate from the rat

  • Published:
Bioscience Reports

Abstract

In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and doJichyl phosphate were determined in rats maintained on a dolichol-free diet for l0 days . Analysis of fecal samples collected every 49 h yielded mean output values of 9.0±1,4 and 20.7±3,0 μg/rat/day of dolichot and dolichy] phosphate, respectively. Urinary output rates were 0.56±0.12 and 0.50±0.2g μg/rat/ day of dolichol and dolichyt phosphate, respectively. Thus, excretion is one fate of endogenously synthesized dolichoI compounds in the rat.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Tavares IA, Coolbear R & Hemming FW (1981) Arch. Biochem. Biophys.207, 427–436.

    PubMed  Google Scholar 

  2. Eggens I, Chojnacki T, Kenne L & Dallner G (1983) Biochim. Biophys. Acta751, 355–368.

    PubMed  Google Scholar 

  3. Gough DP & Hemming FW (1970) Biochem. J.118, 163–166.

    PubMed  Google Scholar 

  4. Potter JER, James MJ & Kandutsch AA (1981) J. Biol. Chem.256, 2371–2376.

    PubMed  Google Scholar 

  5. Wenstrom JC & Hamilton DW (1980) Biol. Reprod.23, 1054–1059.

    PubMed  Google Scholar 

  6. Keller RK, Jehle E & Adair WL Jr (1982) J. Biol. Chem.257, 8985–8989.

    PubMed  Google Scholar 

  7. Adair WL Jr & Keller RK (1982) J. Biol. Chem.257, 8990–8996.

    PubMed  Google Scholar 

  8. Butterworth PHW, Draper HH, Hemming FW, Pennock JF & Morton RA (1963) Biochem. J.89, 32P.

  9. Pullarkat RK & Reha H (1982) J. Biol. Chem.257, 5991–5993.

    PubMed  Google Scholar 

  10. Keller RK, Tamkun JM & Adair WL Jr (1981) Biochemistry20, 5831–5836.

    PubMed  Google Scholar 

  11. Chaudhary N, Freeman DJ, Rip JW & Carroll KK (1982) Lipids17, 588–560.

    Google Scholar 

  12. Folch J, Lees M & Sloane Stanley GH(1957) J. Biol. Chem.226, 497–509.

    PubMed  Google Scholar 

  13. Keller RK & Adair WL Jr (1977) Biochim. Biophys. Acta489, 330–336.

    PubMed  Google Scholar 

  14. Hemming FW (1974) in: Biochemistry of Lipids (Goodwin TW, ed), pp 39–97, Butterworth, London.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of South Florida College of Medicine, 33612, Tampa, Florida, USA

    Lorraine W. Connelly & R. Kennedy Keller

Authors
  1. Lorraine W. Connelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Kennedy Keller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Connelly, L.W., Keller, R.K. Quantitation of excretion of dolichol and dolichyl phosphate from the rat. Biosci Rep 4, 771–776 (1984). https://doi.org/10.1007/BF01128818

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01128818

Keywords

Search

Navigation