Abstract
Selenate efflux from human placental brush border membrane vesicles was studied using an ion-exchange column assay. Selenate efflux was found to be mediated almost exclusively by a temperature dependent DIDS-sensitive pathway. Chromate markedly inhibited selenate efflux: in contrast medium selenate had no effect. It is concluded that selenate and sulphate share a common pathway for transport across the human placental microvillus membrane.
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Abbreviations
- DIDS:
-
4-acetamido-4′-isothiocyanostilbene-2-2′-disulphonate
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Shennan, D.B. A study of selenate efflux from human placental microvillus membrane vesicles. Biosci Rep 7, 675–680 (1987). https://doi.org/10.1007/BF01127681
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DOI: https://doi.org/10.1007/BF01127681