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Influence of cervical sympathetic nerve and hypothalamus on direct cortical responses

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Conclusions

  1. 1.

    During stimulation of the corter at 10/sec the amplitude of the direct cortical response (DCR) is lowered and the negative component disappears: in some cases it may undergo reversal to positive. Prolonged stimulation of the cervical sympathetic nerve (CSN) leads to an appreciable recovery of the negative potential which has disappeared during “fatigue.”

  2. 2.

    In the isolated cortex, “fatigued” DCRs are not restored by the influence of prolonged CSN stimulation.

  3. 3.

    Repeated stimulation of the posterior hypothalamus at 25–100/sec causes facilitation of the negative DCR with phases of waxing and waning of the facilitatory effect. Posterior hypothalamic stimulation causes the appearance of, or intensifies, the initial surface-positive component, and this undergoes recruiting just like the negative phase of the DCR. Less marked changes are observed curing stimulation of the lateral hypothalamus.

  4. 4.

    Gamma-aminobutyric acid (GABA), when applied locally, reverses the negative DCR. DCRs of positive sign, reversed after GABA, are facilitated by the hypothalamus to the same degree as before pharmacological blocking of the dendritic component of the DCR.

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Authors and Affiliations

  1. Orbeli Institute of Physiology, Armenian SSR Academy of Sciences, Erevan

    O. G. Baklavadzhyan, B. A. Arutyunyan & A. G. Darbinyan

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  1. O. G. Baklavadzhyan
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  2. B. A. Arutyunyan
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  3. A. G. Darbinyan
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Baklavadzhyan, O.G., Arutyunyan, B.A. & Darbinyan, A.G. Influence of cervical sympathetic nerve and hypothalamus on direct cortical responses. Neurosci Behav Physiol 1, 403–410 (1967). https://doi.org/10.1007/BF01126532

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