Summary
Prolonged recovery of spontaneous unit activity of the sensorimotor cortex of unanesthetized rabbits, continuing for several seconds or tens of seconds, was studied after cessation of current passed through a recording microelectrode. The extracellularly recorded after-effect following switching off an excitatory (exiting) current could be excitatory or inhibitory, and was opposite in sign to the after-effect observed on the same cells after switching off an inhibitory (entering) current. With intracellular recording, after a depolarizing current, only a subsequent decrease was observed, and after a hyperpolarizing current, only an increase in discharge frequency. It can be concluded from the results of intracellular recording and from a comparative investigation of the same phenomena on an isolated crayfish receptor neuron that the after-effects described in cortical neurons are not connected with the circulation of impulses in neuronal networks, but rather with a special property of the excitable membrane.
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Voronin, L.L., Solntseva, E.I. & Ezrokhi, V.L. Mechanism of after-effects following polarization of single neurons. Neurosci Behav Physiol 2, 871–875 (1968). https://doi.org/10.1007/BF01124734
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DOI: https://doi.org/10.1007/BF01124734