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Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding

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Bioscience Reports

Abstract

Six-hour starvation of lactating rats caused a 75% decrease in mammary-gland lipogenesis. The inhibition of lipogenesis was accompanied by a 45% decrease of blood flow to the mammary gland and a 60% decrease in glucose uptake. Within 2 h of refeeding, lipogenesis and glucose uptake by the gland increased to fed values though blood flow to the gland remained at only 63% of that in the fed state. It is concluded that blood flow, and hence substrate supply, is not a rate-limiting factor for lipogenesis by the lactating mammary gland in the rat.

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Authors and Affiliations

  1. Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK

    Richard G. Jones & Dermot H. Williamson

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  1. Richard G. Jones
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  2. Dermot H. Williamson
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Jones, R.G., Williamson, D.H. Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding. Biosci Rep 4, 421–426 (1984). https://doi.org/10.1007/BF01122507

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  • DOI: https://doi.org/10.1007/BF01122507

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