Skip to main content
SpringerLink
Log in

Up- and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa

  • Short Papers
  • Published:
Bioscience Reports

Abstract

The effects of a cow's milk diet on receptor activity and histamine metabolism in gastric glands and mucosa isolated from adult rats were examined. The milk diet was associated with (1) a decreased mobilization of H2 receptors by histamine and (2) an increased mobilization of PGE2 (prostaglandin E2) receptors in mucous cells (cytoprotective effect) and parietal cells (antiacid effect). These changes are not observed for the receptors reducing pentagastrin- and histamine-induced gastric acid secretion (pancreatic/enteroglucagons, somatostatin) and stimulating mucus, bicarbonate and pepsin secretions in the rat (secretin). Cimetidine produced a parallel displacement of the histamine dose-response curve, suggesting competitive inhibition between this classical H2 receptor antagonist and histamine in the two experimental groups. Prostaglandins and other components in milk such as EGF (epidermal growth factor) and somatostatin might therefore protect gastric mucosa by a differential control of PGE2 and histamine H2 receptor activity eitherdirectly (PGE2 in milk) orindirectly (inhibition of endogeneous histamine synthesis/release and stimulation of PGE-I synthesis/release).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gespach, C., Bataille, D., Dutrillaux, M. C. and Rosselin, G. (1982).Biochim. Biophys. Acta 720:7–16.

    PubMed  Google Scholar 

  2. Dubrasquet, M., Bataille, D. and Gespach, C. (1982)Biosci. Rep. 2:391–395.

    PubMed  Google Scholar 

  3. Forgue-Lafitte, M. E., Kobari, L., Gespach, C., Chamblier, M. C. and Rosselin, G. (1984).Biochim. Biophys. Acta 798:192–198.

    PubMed  Google Scholar 

  4. Major, J. and Scholes, P. (1978).Agents and Actions 8:324–331.

    PubMed  Google Scholar 

  5. Gespach, C., Dupont, C., Bataille, D. and Rosselin, G. (1980).FEBS Lett. 114: 247–252.

    PubMed  Google Scholar 

  6. Gespach, C., Hui Bon Hao, D. and Rosselin, G. (1983).Endocrinology 112:1597–1606.

    PubMed  Google Scholar 

  7. Ray, T., Nandi, J., Pidhorodeckyj, N. and Meng-Ai, Z. (1982).Proc. Natl. Acad. Sci. USA 79:1448–1452.

    PubMed  Google Scholar 

  8. Gespach, C., Emami, S. and Rosselin, G. (1984).Biochem. Biophys. Res. Comm. 120: 641–649.

    PubMed  Google Scholar 

  9. Gespach, C., Bataille, D., Vauclin, N., Moroder, L., Wünch, E. and Rosselin, G. (1986).Peptides 7:155–163.

    Google Scholar 

  10. Watson, L. C. and Abston, S. (1976).Am. J. Surg. 132:790–793.

    PubMed  Google Scholar 

  11. Dial, E. J. and Lichtenberger, L. M. (1984).Gastroenterology 87:379–385.

    PubMed  Google Scholar 

  12. Werner, H., Amarant, T., Millar, R., Fridkin, M. and Koch, Y. (1985).Eur. J. Biochem. 148:353–357.

    PubMed  Google Scholar 

  13. Carpenter, G. (1980).Science 210:198–199.

    PubMed  Google Scholar 

  14. Shing, Y. and Klagsbrun, M. (1984).Endocrinology 115:273–282.

    PubMed  Google Scholar 

  15. Bano, M., Salomon, D. and Kidwell, W. (1985).J. Biol. Chem. 260:5742–5752.

    Google Scholar 

  16. Read, L., Francis, G., Wallace, J. and Ballard, F. (1985).J. Dev. Physiol. 7:135–145.

    PubMed  Google Scholar 

  17. Petrides, P., Hosang, M., Shooter, E., Esch, F. and Böhlen, P. (1985).FEBS Lett. 187:89–95.

    PubMed  Google Scholar 

  18. Materia, A., Jaffe, B., Money, S., Rossi, P., De Marco, M. and Basso, N. (1984).Arch. Surg. 119:290–292.

    PubMed  Google Scholar 

  19. Werner, H., Koch, Y., Fridkin, M., Fahrenkrug, J. and Gozes, I. (1985).Biochem. Biophys. Res. Comm. 133:228–232.

    PubMed  Google Scholar 

  20. Ekman, R., Ivarsson, S. and Jansson, L. (1985).Regulatory Peptides 10:99–105.

    PubMed  Google Scholar 

  21. Gespach, C., Bataille, D., Dupont, C., Rosselin, G., Wünsch, E. and Jaeger, E. (1980).Biochim. Biophys. Acta 630:433–441.

    PubMed  Google Scholar 

  22. Gespach, C., Cherel, Y. and Rosselin, G. (1984).Am. J. Physiol.,247:G231-G239.

    PubMed  Google Scholar 

  23. Haimart, M., Launay, J. M., Zürcher, G., Cauet, N., Dreux, C. and Da Prada, M. (1985).Agents and Actions 16:71–75.

    PubMed  Google Scholar 

  24. Barros D'sa, A., Bloom, S. and Baron, J. (1975).The Lancet 1:886–887.

    Google Scholar 

  25. Chew, C. (1983).Am. J. Physiol. 245:G221-G229.

    PubMed  Google Scholar 

  26. Prost, A., Emami, S. and Gespach, C. (1984).FEBS Lett. 177:227–230.

    PubMed  Google Scholar 

  27. Emami, S. and Gespach, C. (1986).Agents and Actions 18:129–133.

    PubMed  Google Scholar 

  28. Boissard, C., Marie, J.-C., Hejblum, G., Gespach, C. and Rosselin, G. (1986).Cancer Research 46:4406–4413.

    PubMed  Google Scholar 

  29. Speir, G., Takeuchi, K., Peitsch, W. and Johnson, L. (1982).Am. J. Physiol. 242:G243-G249.

    PubMed  Google Scholar 

  30. Rice, M., McRae, J., Storm, D. and Robertson, R. (1981).Am. J. Physiol. 241:E291-E297.

    PubMed  Google Scholar 

  31. Gespach, C., Emami, S., Boige, N. and Rosselin, G. (1983). In:Gut Peptides and Ulcer (A. Miyoshi, Ed.), Biomedical Research Foundation, Tokyo, pp. 56–63.

    Google Scholar 

  32. Emami, S., Gespach, C., Forgue-Lafitte, M.-E., Broer, Y. and Rosselin, G. (1983).Life Sci. 33:415–423.

    Google Scholar 

  33. Emami, S. and Gespach, C. (1986).Biochem. Pharm. 35:1825–1834.

    PubMed  Google Scholar 

  34. Gespach, C., Saal, F., Cost, H. and Abita, J.-P. (1982).Mol. Pharmacol. 22:547–553.

    PubMed  Google Scholar 

  35. Gespach, C. and Abita, J.-P. (1982).Mol. Pharmacol. 21:78–85.

    PubMed  Google Scholar 

  36. Sibley, D. and Lefkowitz, R. (1985).Nature 317:124–129.

    PubMed  Google Scholar 

  37. Fisher, D., Meier, E. and Fitzpatrick, D. (1981).Comp. Biochem. Physiol. 68C:231–234.

    Google Scholar 

  38. Thiebaut, R., Garzon, B., Millet, P., Moreau, E., Ducroc, R. and Geloso, J.-P. (1985).J. of Pediatr. Gastroenterol. Nutr. 4:482–488.

    Google Scholar 

  39. Subbiah, M., Yunker, R., Yamamoto, M., Hottke, B. and Bale, L. (1985).Biochem. Biophys. Res. Comm. 129:972–976.

    PubMed  Google Scholar 

  40. Tyler, M., Schearman, D., Franco, R., O'Brien, P., Seamark, R. and Kelly, R. (1983).Science 220:609–610.

    PubMed  Google Scholar 

  41. Postius, S., Ruoff, H. J. and Szelenyi, I. (1985).Br. J. Pharmac. 84:871–877.

    Google Scholar 

  42. Feldman, M. (1983).J. Clin. Invest. 72:295–303.

    PubMed  Google Scholar 

  43. Chang, K.-J., Killian, A., Hazum, E. and Cuatrecasas, P. (1981).Science 212:75–77.

    PubMed  Google Scholar 

  44. Chang, K.-J., Fu Su, Y., Brent, D. and Chang, J.-K. (1985).J. Biol. Chem. 260:9706–9712.

    PubMed  Google Scholar 

  45. Reyl, F. and Lewin, M. (1981).Biochim. Biophys. Acta 675:297–300.

    PubMed  Google Scholar 

  46. Reyl, F. and Lewin, M. (1982).Proc. Natl. Acad. Sci. USA 79:978–982.

    PubMed  Google Scholar 

  47. Anteunis, A., Gespach, C., Astesano, A., Emami, S., Robineaux, R. and Rosselin, G. (1984).Peptides 5:277–283.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM U. 55, Unité de Recherches sur les peptides neurodigestifs et le diabète, Hôpital Saint-Antoine, 75571, Paris Cedex 12

    C. Gespach, S. Emami, E. Chastre & G. Rosselin

  2. Laboratoire de Biochimie et de Neuroendocrinologie, Hôpital Saint-Louis, 75475, Paris Cedex 10, France

    J. -M. Launay

Authors
  1. C. Gespach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Emami
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Chastre
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. -M. Launay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Rosselin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gespach, C., Emami, S., Chastre, E. et al. Up- and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa. Biosci Rep 7, 135–142 (1987). https://doi.org/10.1007/BF01121877

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01121877

Key Words

Search

Navigation