Abstract
A model is described whereby (i) regulatory proteins recognize one face of the DNA double helix on non-adjacent DNA regions brought close together in space through folding around nucleosomes, (if) regulatory sequences may occur inside gene structures, and (iii) the recognition of regulatory sequences might be modulated by short (4–6 base-pairs) insertions or deletions in introns or upstream from the transcription start site. This model might apply not only to eucaryotes but also to procaryotic organisms whose DNA is organized through interactions with histone-like proteins. Consequences of the model regarding the binding of regulatory proteins in procaryotes are suggested.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bogenhagen DF, Sakonju S & Brown DD (1980) Cell19, 27–35.
Caruthers MH (1980) Accounts Chem. Res.13, 155–160.
Chao MV, Gralla J & Martinson MG (1979) Biochemistry18, 1068–1074.
Chao MV, Martinson HG & Gralla JD (1980) Biochemistry19, 3260–3269.
Charlier M, Maurizot JC & Zaccaï G (1980) Nature286, 423–425.
DiLauro R, Taniguchi T, Musso R & de Crombrugghe B (1979) Nature279, 494–500.
Engelke DR, Ng SY, Shastry BS, & Roeder RG (1980) Cell19, 717–728.
Finch JT, Lutter LC, Rhodes D, Brown RS, Rushton B, Levitt M & Klug A (1977) Nature269, 29–36.
Fowlkes DM & Shenk T (1980) Cell22, 405–413.
Gannon F, Jeltsch JM & Perrin F (1980) Nucl. Acids Res.8, 4405–4421.
Gierer A (1966) Nature212, 1480–1481.
Hübscher U, Lutz H & Kornberg A (1980) Proc. Natl. Acad. Sci. U.S.A.77, 5097–5101.
Igo-Kemenes T, Omori A & Zachau HG (1980) Nucl. Acids Res.22, 5377–5390.
Klevan L & Wang JC (1980) Biochemistry19, 5229–5234.
Kressmann A, Hofstetter H, Di Capua E, Grosschedl R & Birnstiel ML (1979) Nucl. Acids Res.7, 1749–1763.
Kuo MT, Mandel JL & Chambon P (1979) Nucl. Acids Res.7, 2105–2113.
Lim VI & Mazanov AL (1978) FEBS Lett.88, 118–123.
Lohr D & Van Holde KE (1979) Proc. Natl. Acad. Sci. U.S.A.76, 6326–6330.
Louis C, Schedl P, Samal B & Worcel A (1980) Cell22, 387–392.
Lutter LC (1979) Nucl. Acids Res. 6, 41–56.
McGhee JD & Felsenfeld G (1980) Ann. Rev. Biochem.49, 1115–1156.
McGhee JD, Rau DC, Charney E & Felsenfeld G (1980) Cell22, 87–96.
Rouvière-Yaniv J, Yaniv M & Germond JE (1979) Cell17, 265–274.
Sakonju S, Bogenhagen DF & Brown DD (1980) Cell19, 13–25.
Schmitz A & Galas DJ (1979) Nucl. Acids Res. 6, 111–137.
Siebenlist U, Simpson RB & Gilbert W (1980) Cell20, 269–281.
Simpson RB (1979) Nucl. Acids Res.8, 759–766.
Stalder J, Larsen A, Engel JD, Dolan M, Grouding M & Weintraub H (1980) Cell20, 451–460.
Tatchell K & Van Holde KE (1979) Biochemistry18, 2871–2880.
Van Holde KE, Allen JR, Tatchell K, Weischet WO & Lohr D (1980) Biophys. J.32, 271–282.
Varshavsky AJ, Sundïn O & Bohn M (1979) Cell16, 453–466.
Weintraub M (1980) Nucl. Acids Res.8, 4745–4753.
Wilson JH (1979). Proc. Natl. Acad. Sci. U.S.A.8, 3641–3645.
Wittig B & Wittig S (1979) Cell18, 1173–1183.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hélène, C. Recognition of base sequences by regulatory proteins in procaryotes and eucaryotes. Biosci Rep 1, 477–483 (1981). https://doi.org/10.1007/BF01121581
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01121581