Abstract
Lipogenesis in livers of fed but not of starved rats is increased after intragastric feeding with glucose. In contrast, lipogenesis in brown adipose tissue increases in both fed and starved animals. These observations suggest that lipogenesis in brown adipose tissue is regulated by mechanisms in addition to, or other than, those operating in liver. The fate of newly synthesized lipid in brown adipose tissue is not known. However, the formation of palmitoyl-carnitine from palmitoyl-CoA and carnitine by mitochondria from brown fat was inhibited by malonyl-CoA. Although inhibition was not 100%, it is implied that mitochondrial uptake of the newly synthesized fat by the carnitine acyltransferase system is restricted under conditions of increased lipogenesis.
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References
Agius L & Williamson DH (1980a) Biochem. Soc. Trans. 8, 590–591.
Agius L & Williamson DH (1980b) Biochem. J. 190, 477–480.
Bradford MM (1976) Anal. Biochem. 72, 248–254.
Cannon B & Johansson BW (1980) inMolecular Aspects of Medicine (Gergely J & Baum H, eds), vol 3, pp 119–223, Pergamon Press, London.
Czech MP, Lawrence JC Jr & Lynn WS (1974) J. Biol. Chem. 249, 5421–5429.
Drahota Z (1970) inBrown Adipose Tissue (Lindberg O, ed), pp 225–244, Elsevier, New York.
Foster DO & Frydman ML (1979) Can. J. Physiol. Pharmacol. 57, 257–270.
Halestrap AR & Denton RM (1973) Biochem. J. 132, 509–517.
Himms-Hagen J (1979) Can. Med. Assoc. J. 121, 1361–1364.
Kopec B & Fritz IB (1973) J. Biol. Chem. 248, 4069–4074.
Malaisse WJ, Sener A & Levy J (1976) J. Biol. Chem. 251, 1731–1737.
McCormack JG & Denton RM (1977) Biochem. J. 166, 627–630.
McCormack JG & Denton RM (1980) Biochem. J. 190, 95–105.
McGarry JD, Leatherman GF & Foster DW (1978) J. Biol. Chem. 253, 4128–4136.
Nedergaard J, Alexson S & Cannon B (1980) Am. J. Physiol. 239, C208–216.
Nicholls DG (1979) Biochim. Biophys. Acta 549, 1–29.
Norum KR (1964) Biochim. Biophys. Acta 89, 95–108.
Parvin R & Pande SV (1979) J. Biol. Chem. 254, 5423–5429.
Rath EA, Salmon DMW & Hems DA (1979) FEBS Lett. 108, 33–36.
Rothwell NJ & Stock MJ (1979) Nature (London) 281, 31–35.
Shetty PS, Jung RT, James WPT, Barrand MA & Cunningham BA (1981) Clin. Science 60, 519–525.
Slein MW (1963) inMethods of Enzymatic Analysis (Bergmeyer HU, ed), pp 117–123, Academic Press, New York and London.
Smith RE & Horwitz BA (1969) Physiol. Rev. 49, 330–425.
Stansbie D, Brownsey RW, Crettaz M & Denton RM (1976) Biochem. J. 160, 413–416.
Sugden PH & Newsholme EA (1977) Comp. Biochem. Physiol. 56C, 89–94.
Thurlby PL & Trayhurn P (1980) Pflügers Arch. 385, 193–201.
Trayhurn P (1979) FEBS Lett. 104, 13–16.
Williamson DH, Mellanby J & Krebs HA (1962) Biochem. J. 82, 90–96.
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Sugden, M.C., Watts, D.L. & Marshall, C.E. Lipogenesis in response to an oral glucose load in fed and starved rats. Biosci Rep 1, 469–476 (1981). https://doi.org/10.1007/BF01121580
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DOI: https://doi.org/10.1007/BF01121580