Abstract
The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in thein vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant.
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Rivabene, R., Cantafora, A., Yan, C.C. et al. Effect of HDL1 infusion on biliary secretion in perfused rat liver. Biosci Rep 12, 425–432 (1992). https://doi.org/10.1007/BF01121506
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DOI: https://doi.org/10.1007/BF01121506