Skip to main content

Advertisement

Log in

Pharmacological control of gastric acid secretion: Molecular and cellular aspects

  • Review
  • Published:
Bioscience Reports

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ackerman, S. H. (1982) Ontogeny of gastric acid secretion in the rat: Evidence for multiple response systems.Science 217:75.

    Google Scholar 

  2. Aktories, A., Schultz, G. and Jakobs, K. H. (1983) Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants.Molecular Pharm. 24:183.

    Google Scholar 

  3. Amatruda III, T. T., Steele, D., Slepak, V. Z. and Simon, M. (1991) Gα16, a G protein α subunit specifically expressed in hematopoietic cells.Proc. Natl. Acad. Sci. USA 88:5587.

    Google Scholar 

  4. Anand, S. and Van Thiel, D. H. (1982) Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males.Science 218:493.

    Google Scholar 

  5. Anderson, N. G. and Hanson, P. J. (1985) Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells.Biochem. J. 232:609.

    Google Scholar 

  6. Arima, N., Yamashita, Y., Nakata, H., Nakamura, A., Kinoshita, Y. and Chiba, T. (1991). Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment.Biochem. Biophys. Res. Commun. 176:1027.

    Google Scholar 

  7. Arrang, J. M., Garbarg, M., Lancelot, J. C., Lecomte, J. M., Pollard, H., Robba, M., Schunack, W. and Schwartz, J. C. (1987) Highly potent and selective ligands for histamine H3-receptors.Nature 327:117.

    Google Scholar 

  8. Arrang, J. M., Garbarg, M. and Schwartz, J. C. (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.Nature 302:832.

    Google Scholar 

  9. Arrang, J. M., Roy, J., Morgat, J. L., Schunack, W. and Schwartz, J. C. (1990) Histamine H3 receptor binding sites in rat brain membranes. Modulations by guanyl nucleotides and divalent cations.Eur. J. Pharmacol. 188:219.

    Google Scholar 

  10. Ashkenazi, A., Winslow, J. W., Peralta, E. G., Peterson, G. L., Schimerlik, M. I., Capon, D. J. and Ramachandran, J. (1987) An M2 muscarinic receptor subtype coupled to both adenylyl and phosphoinositide turnover.Science 238:672.

    Google Scholar 

  11. Atwell, M. M. and Hanson, P. J. (1988) Effect of pertussis toxin on the inhibition of secretory activity by prostaglandin E2, somatostatin, epidermal growth factor and 12-O-tetradecanoiylphorbol 13-acetate in parietal cells from rat stomach.Biochim. Biophys. Acta 971:282.

    Google Scholar 

  12. Audousset-Puech, M. P., Jarrousse, C., Dubrasquet, M., Aumelas, A., Castro, B., Bataille, D. and Martinez, J. (1985) Synthesis of the C-terminal octapeptide of pig oxyntomodulin Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala: A potent inhibitor of pentagastrin-induced acid secretion.J. Med. Chem. 28:1529.

    Google Scholar 

  13. Auger, K. R., Serunian, L. A., Soltoff, S. P., Libby, P. and Cantley, L. C. (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.Cell 57:167.

    Google Scholar 

  14. Avril, P., Ducroc, R., Garzon, B., Moreau, E., Hervatin, F., Millet, P. and Geloso, J. P. (1986) Développement de la sensibilité gastrique à l'histamine chez le rat.C. R. Acad. Sci. 18:739.

    Google Scholar 

  15. Aymard, J. P., Aymard, B., Netter, P., Bannwarth, B., Trechot, P. and Streiff, F. (1988) Haematological adverse effects of histamine H2-receptor antagonists.Medical Toxicology 3: 430.

    Google Scholar 

  16. Azuma, J., Sawamura, A., Harada, H., Tanimoto, T., Ishiyama, T., Morita, Y., Yamamura, Y. and Sperelakis, N. (1981) Cyclic adenosine monophosphate modulation of contractility via slow Ca2+ channels in chick heart.J. Mol. Cell. Cardiol. 13:577.

    Google Scholar 

  17. Bado, A., Moizo, L., Laigneau, J. P. and Lewin, M. J. M. (1992) Pharmacological characterization of histamine H3 receptors in isolated rabbit gastric glands.Am. J. Physiol. 262:G56.

    Google Scholar 

  18. Bakalyar, H. A. and Reed, R. R. (1990) Identification of a Specialized Adenylyl Cyclase that May Mediate Odorant Detection.Science 250:1403.

    Google Scholar 

  19. Barr, D. B., Duncan, J. A., Kiernan, J. A., Soper, B. D. and Tepperman, B. L. (1988) Binding and biological actions of prostaglandin E2 and I2 in cells isolated from rabbit gastric mucosa.J. Physiol. 405:39.

    Google Scholar 

  20. Bast, A., Smid, K. and Timmerman, H. (1989). The effects of cimetidine, ranitine and famotidine on rat hepatic microsomal cytochrome P-450 activities.Agents and Actions 27:188.

    Google Scholar 

  21. Bataille, D. (1987) Entéroglucagons: état actuel.Gastroenter. Clin. Biol. 11:217.

    Google Scholar 

  22. Batzri, S., Harmon, J. W., Dyer, J. and Thompson, W. F. (1982) Interaction of histamine with gastric mucosal cells. Effect of histamine H2 antagonists on binding and biological response.Molec. Pharmacol. 22:41.

    Google Scholar 

  23. Batzri, S. (1984) Action of tricyclic antidepressants on cyclic AMP in mucosal cells from guinea pig stomach.Eur. J. Pharmac. 105:167.

    Google Scholar 

  24. Bawab, W., Chastre, E. and Gespach, C. (1991) Functional and structural characterization of the secretin receptors in rat gastric glands: Desensitization and glycoprotein nature.Biosci. Rep. 11:33.

    Google Scholar 

  25. Bearer, C. F., Chang, L. K., Rosenfeld, G. C. and Thompson, W. J. (1981) Histamine stimulation of rat gastric parietal cell adenylyl cyclase: modulation by guanine nucleotides.Arch. Biochem. Biophys. 207:325.

    Google Scholar 

  26. Beaven, M. A., Soll, A. H. and Lewin, K. J. (1982) Histamine synthesis by intact mast cells from canine fundic mucosa and liver.Gastroenterol. 82:254.

    Google Scholar 

  27. Beil, W., Staar, U. and Sewing, K. F. (1987) SCH 28080 is a more selective inhibitor than SCH 32651 at the K+ site of gastric K+/H+-ATPase.Eur. J. Pharm. 139:349.

    Google Scholar 

  28. Berglindh, T., Helander, H. and Obrink, K. (1976) Effects of secretagogues on oxygen consumption, aminopyrine accumulation and morphology in isolated gastric glands.Acta Physiol. Scand. 97:401.

    Google Scholar 

  29. Berglindh, T., Sachs, G. and Takeguchi, N. (1980) Ca2+-dependent secretagogue stimulation in isolated gastric glands.Am. J. Physiol. 239:G90.

    Google Scholar 

  30. Bergmark, J., Granérus, G., Henningsson, S., Lundell, L. and Rosengren, E. (1976) Histamine metabolism of the guinea pig gastric mucosa.J. Physiol. 257:419.

    Google Scholar 

  31. Berlin, R. G. (1987) Famotidine does not have a negative inotropic effect.The Lancet 2:1468.

    Google Scholar 

  32. Berlin, R. G. (1991) Omeprazole: Gastrin and gastric endocrine cell data from clinical studies.Dig. Dis. Sci. 36:129.

    Google Scholar 

  33. Berridge, M. J. and Irvine, R. F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction.Nature 312:315.

    Google Scholar 

  34. Bertaccini, G., Coruzzi, G., Poli, E. and Adami, M. (1986) Pharmacology of the novel H2 antagonist famotidine:in vitro studies.Agents and Actions 19:180.

    Google Scholar 

  35. Black, E. W., Cornwell, T. L., Lincoln, T. M., Strada, S. J., Thompson, W. J. (1989) Fura 2 analysis of cytosolic calcium regulation in elutriated rat gastric parietal cells.J. Cell. Physiol. 139:632.

    Google Scholar 

  36. Black, J., Duncan, W., Durant, C., Ganellin, C. and Parsons, M. (1972) Definition and antagonism of histamine H2 receptors.Nature 236:385.

    Google Scholar 

  37. Black, J. W., Leff, P. and Shankley, N. P. (1985) Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay.Br. J. Pharmac. 86:581.

    Google Scholar 

  38. Blakemore, R. C., Brown, T. H., Durant, G. J., Ganelin, C. R., Parsons, M. E., Rasmussen, A. C. and Rawlings, D. A. (1981) SKF 93479, a potent and long acting histamine H2-receptor antagonist.Proc. of the B.P.S., April 200P.

  39. Bodenmar, G., Norlander, B., Fransson, L. and Walan, A. (1979) The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on the absorption of cimetidine: studies in patients with peptic ulcer disease.Br. J. Clin. Pharmacol. 7:23.

    Google Scholar 

  40. Bohman, T., Myren, J., Flaten, O. and Schrumpf, E. (1990) The effect of trimipramine, cimetidine and atropine on gastric secretion.Scand. J. Gastroenterol. 15:177.

    Google Scholar 

  41. Boige, N., Dupont, C., Chrenut, B., Gespach, C. and Rosselin, G. (1984) Beta-adrenergic regulation of cyclic adenosine 3′,5′monophosphate accumulation in human gastric epithelial glands. Inhibitory effect of somatostatin.Eur. J. Clin. Invest. 14:42.

    Google Scholar 

  42. Bonner, T. I. (1992) Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling.TIPS 13:48.

    Google Scholar 

  43. Bonventre, J. V. and Swidler, M. (1988) Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells.J. Clin. Invest. 82:168.

    Google Scholar 

  44. Borch, K., Renvall, H. and Liedberg, G. (1985) Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia.Gastroenterol. 88:638.

    Google Scholar 

  45. Bordi, C., D'Adda, T., Pilato, F. P. and Ferrari, C. (1987) Carcinoid (ECL cell) tumor of the oxyntic mucosa of the stomach. A hormone-dependent neoplasm?Prog. Surg. Pathol. 8:177.

    Google Scholar 

  46. Bottari, S. (1989) Nuclear somatostatin receptors. The gastrointestinal epithelium, International conference, Riom September 24, France, abstr.

  47. Brass, L. F., Woolkalis, M. J. and Manning, D. R. (1988) Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.J. Biol. Chem. 263:5348.

    Google Scholar 

  48. Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R. and Snyder, S. H. (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.Nature 351:714.

    Google Scholar 

  49. Brimblecombe, R. W. and Duncan, W. A. M. (1977) The relevance to man of preclinical data for cimetidine. In: Burland WL, Simkins MA, eds. Cimetidine, Proceedings of the Second International Symposium on Histamine H2 receptor antagonists. Amsterdam:Exerpta Medica.112.

    Google Scholar 

  50. Brittain, R. T., Jack, D., Reeves, J. J. and Stables, R. (1985) Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an unsurmountable histamine H2-receptor blocking drug.Br. J. Pharmac. 85:843.

    Google Scholar 

  51. Buechler, W. A., Nakane, M. and Murad, F. (1991) Expression of soluble guanylate cyclase activity requires both enzyme subunits.Biochem. Biophys. Res. Commun. 174:351.

    Google Scholar 

  52. Burland, W. L. and Mills, J. G. (1982) The pathophysiological role of histamine and potential therapeutic uses of H1 and H2 anthihistamine. In: Wright PSG, ed. Pharmacology of histamine receptors. The stone bridge press, Bristol, London, Boston, p 436.

  53. Burlinson, B., Morriss, S., Gatehouse, D. G., Tweats, D. J. and Jackson, M. R. (1991) Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole.Mutagenesis 6:11.

    Google Scholar 

  54. Burman, P., Mardh, S., Norberg, L. and Karlsson, A. (1989) Parietal Cell Antibodies in Pernicious Anemia Inhibit H+, K+-Adenosine Triphosphatase, the Proton Pump of the Stomach.Gastroenterol. 96:1434.

    Google Scholar 

  55. Burns, D. J. and Bell, R. M. (1991) Protein Kinase C Contains Two Phorbol Ester Binding Domains.J. Biol. Chem. 266:18330.

    Google Scholar 

  56. Byron, J. W. (1980) Pharmacodynamic basis for the interaction of cimetidine with the bone marow stem cells (CFUs).Exp. Hematol. 8:256.

    Google Scholar 

  57. Cabero, J. L., Li, Z.-Q. and Mardh, S. (1991) Gastrin potentiates histamine-stimulated aminopyrine accumulation in isolated rat parietal cells.Am. J. Physiol. 261:G621.

    Google Scholar 

  58. Campbell, V. W. and Yamada, T. (1989) Acid Secretagogue-induced Stimulation of Gastric Parietal cell gene expression.J. Biol. Chem. 264:11381.

    Google Scholar 

  59. Campbell, V. W. and Yamada, T. (1991) Effect of omeprazole on gene expression in canine gastric parietal cells.Am. J. Physiol. 260:G434.

    Google Scholar 

  60. Canfield, S. P., Curwain, B. P. and Price, C. (1978)β-adrenoreceptor agonist stimulation of acid secretion in rat isolated stomach.Proc. of the B.P.S. 425P.

  61. Canfield, V. A., Okamoto, C. T., Chow, D., Dorfman, J., Gros, P., Forte, J. G. and Levenson, R. (1990) Cloning of the H, K-ATPase β Subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na, K-ATPase β bununits.J. Biol. Chem. 265:8.

    Google Scholar 

  62. Canfield, V. A. and Levenson, R. (1991) Structural organization and transcription of the mouse gastric H+, K+-ATPase β subunit gene.Proc. Natl. Acad. Sci. USA 88:8247.

    Google Scholar 

  63. Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R. and Soltoff, S. (1990) Oncogenes and signal transduction.Cell. 64:281.

    Google Scholar 

  64. Carney, J. A., Go, V. L. W., Fairbanks, V. F., Moore, B. A., Alport, E. C. and Nora, F. E. (1983) The syndrome of gastric argyrophil carcinoid tumors and non-antral gastric atrophy.Ann. Intern. Med. 99:761.

    Google Scholar 

  65. Carpenter, C. L. and Cantley, L. C. (1990) Phosphoinositide kinases.Biochemistry 29:11147.

    Google Scholar 

  66. Carpenter, C. L., Duckworth, B. C., Auger, K. R., Cohen, B., Schaffhausen, B. S. and Cantley, L. C. (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver.J. Biol. Chem. 265:19704.

    Google Scholar 

  67. Carpentier, J. L., Gorden, P., Robert, A. and Orci, L. (1986) Internalization of polypeptide hormones and receptor recycling.Experientia 42:734.

    Google Scholar 

  68. Chang, R. S. L., Lotti, V. J. and Chen, T. B. (1985) Cholecystokinin receptor mediated hydrolysis of inositol phospholipids in guinea pig gastric glands.Life Sci. 36:965.

    Google Scholar 

  69. Charbon, G. A., Brouwers, H. A. and Sala, A. (1980) Histamine H1- and H2-receptors in the gastrointestinal circulation.Naunyn-Schemiedeberg's Arch. Pharmacol. 312:123.

    Google Scholar 

  70. Chastre, E., Emami, S. and Gespach, C. (1989) Expression of membrane receptors and (proto)oncogenes during the oncogenic development and neoplasic transformation of the intestinal mucosa.Life Sci. 44:1721.

    Google Scholar 

  71. Chastre, E., Emami, S. and Gespach, C. (1991) Immortalisation et transformation tumorale de l'épithélium gastro-intestinal chez l'homme et le rat: applications en cancérologie et dans la mucoviscidose.Méd. Sci. 7:17.

    Google Scholar 

  72. Cheng, H. C., Gleason, E. M., Nathan, B. A., Lachman, P. J. and Woodward, J. K. (1981) Effects of clonidine on gastric acid secretion in the rat.J. Pharmacol. Exp. Ther. 217:121.

    Google Scholar 

  73. Cheret, A. M., Pignal, F. and Lewin, J. M. (1981) Effects of H2-receptor antagonists cimetidine, ranitidine and ICI 125,211 on histamine-stimulated adenylate cyclase activity in guinea pig gastric mucosa.Molec. Pharmac. 20:326.

    Google Scholar 

  74. Chew, C. (1985) Parietal cell protein kinases selective activation of type I cAMP-dependent protein kinase by histamine.J. Biol. Chem. 260:7540.

    Google Scholar 

  75. Chew, C. S., Ljungström, M., Smolka, A. and Brown, M. R. (1989) Primary culture of secretagogue-responsive parietal cells from rabbit gastric mucosa.Am. J. Physiol. 256:G254.

    Google Scholar 

  76. Chiba, T., Fisher, S. K., Agranoff, B. W. and Yamada, T. (1989) Autoregulation of muscrarinic and gastrin receptors on gastric cells.Am. J. Physiol. 256:G356.

    Google Scholar 

  77. Cho-Chung, Y. S. (1990) Role of cyclic AMP receptor protein in growth, differentiation, and suppression of malignancy: New approaches to therapy.Canc. Res. 50:7093.

    Google Scholar 

  78. Christiansen, J., Ottenjann, R., Von Arx and the study group (1989). Placebo-controlled trial with the somatostatin analogue SMS 201–995 in peptic ulcer bleeding.Gastroenterol. 97:568.

    Google Scholar 

  79. Clegg, C. H., Codd, G. G. and McKnight, G. S. (1988) Genetic characterization of a brain specific form of the type I regulatory subunit of cAMP-dependent protein kinase.Proc. Natl. Acad. Sci. USA,85:3703.

    Google Scholar 

  80. Cockcroft, S. (1987) Polyphosphoinositide phosphotiesterase: regulation by a novel guanine nucleotide binding protein, Gp.Trends in Biochem. Sci. 12:75.

    Google Scholar 

  81. Corinaldesi, D. R., Pasquali, R., Paternico, A., Stanghellini, V., Paparo, G. F., Ricci, Maccarini, M. and Barbara, L. (1987) Effects of short- and long-term administrations of famotidine and ranitidine on some pituitary, sexual and thyroid hormones.Drugs Explt. Clin. Res. 10:647.

    Google Scholar 

  82. Crothers, J. M., Reenstra, W. and Forte, J. G. (1990) Ontogeny of gastric H+-K+-ATPase in suckling rabbits.Am. J. Physiol. 257:G913.

    Google Scholar 

  83. Culp, D. J., Wolosin, J. M., Soll, A. H. and Forte, J. G. (1983) Muscarinic receptors and guanylate cyclase in mammalian gastric glandular cells.Am. J. Physiol. 245:G760.

    Google Scholar 

  84. Currie, M. G., Fok, K. F., Kato, J., Moore, R. J., Hamra, F. K., Duffin, K. L. and Smith, C. E. (1992) Guanylin: An endogenous activator of intestinal guanylate cyclase.Proc. Natl. Acad. Sci. USA 89:947.

    Google Scholar 

  85. Curwain, B. P. and Turner, N. C. (1981) The involvement of histamine receptor subtypes in gastric acid secretion and mucosal blood flow in the anaesthetized rabbit.J. Physiol. 311:431.

    Google Scholar 

  86. D'Adda, T., Pilato, F. P., Lazzaroni, M., Robutti, F., Bianchi-Porro, G. and Bordi, C. (1991) Ultrastructural Morphometry of Gastric Endocrine Cells Before and After Omeprazole. A study in the oxyntic mucosa of duodenal ulcer patients.Gastroenterol. 100:1563.

    Google Scholar 

  87. Daly, M. J., Humphray, J. M. and Stables, R. (1981) Somein vitro andin vivo actions of the new histamine H2-receptor antagonist, ranitidine.Br. J. Pharmac. 72:49.

    Google Scholar 

  88. Dammann, H. G., Walter, T. A., Hentschel, E., Muller, P. and Simon, B. (1987) Famotidine: proven once-a-day treatment for gastric ulcer.Scand. J. Gastroenterol. 22:29.

    Google Scholar 

  89. Dam Trung Tuong, M., Garbarg, M. and Schwartz, J. C. (1980) Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations.Nature 28:548.

    Google Scholar 

  90. Daniel, H., Vohwinkel, M. and Rehner, G. (1990) Effect of casein and β-casomorphins on gastrointestinal motility in rats.J. Nutr. 120:252.

    Google Scholar 

  91. Davison, J. S. and Najafi-Farashah, A. (1982) The effect of dibutyryl cyclic GMP, a competitive antagonist to cholecystokinin-pancreozymin, on gastric acid secretion in the isolated mouse stomach.Life Sci. 31:355.

    Google Scholar 

  92. Decktor, D. L., Pendleton, R. G., Kellner, A. T. and Davis, M. A. (1989) Acut effects of ranitidine, famotidine and omeprazole on plasma gastrin in the rat.J. Pharmac. Exp. Ther. 249:1.

    Google Scholar 

  93. Dedieu-Chaufour, C., Hertz, F., Caussade, F. and Cloarec, A. (1991) Pharmacological Profile of UP 5145-52, an Original Antiulcer and Antisecretory Agent.J. Pharmacol. Exp. Ther. 259:190.

    Google Scholar 

  94. Dembinski, A., Gregory, H., Konturek, S. J. and Polanski, M. (1982) Trophic action of epidermal growth factor on the pancreas and gastrointestinal mucosa in rats.J. Physiol. 325:35.

    Google Scholar 

  95. Depigny, C., Lupo, B., Kervran, A., and Bataille, D. (1984) Mise en évidence d'un site récepteur spécifique du glucagon-37 (Oxyntomodulin/Enteroglucagon bioactif) dans les glandes oxyntiques de rat.C. R. Acad. Sci. Paris 299:677.

    Google Scholar 

  96. Dhumeaux, D. and Delchier, J. C. (1988) Interactions des inhibiteurs de la sécrétion acide gastrique avec le système microsomal hépatique d'oxydation des médicaments. In: Contrôle de la sécrétion acide, Mignon, M., Galmiche, J. P., Ruszniewski, P. and Pappo, M. John Libbey Eurotext, Paris,129.

    Google Scholar 

  97. Dickey, W. and Symington, M. (1987) Broad-complex tachycardia after intravenous cimetidine.The Lancet i 8523:99.

    Google Scholar 

  98. Dickinson, K. E. J., Anderson, W., Matsumoto, H. and Uemura Hirschowitz, B. I. (1989)125I-iodopindolol binding to frog esophageal peptic cells. Detection of amine uptake and β-adrenergic receptors coupled to pepsinogen secretion.Biochem. Pharm. 38:1481.

    Google Scholar 

  99. Diez, E. and Mong, S. (1990) Purification of a phospholipase A2 from human monocytic leukemic U937 cells.J. Biol. Chem. 265:14654.

    Google Scholar 

  100. Dinda, P. K., Leddin, D. J. and Beck, I. T. (1988) Histamine is involved in ethanol-induced jejunal microvascular injury in rabbits.Gastroenterol. 95:1227.

    Google Scholar 

  101. Dobrilla, G., De Pretis, G., Piazzi, L., Boero, A., Camarri, E., Crespi, M., Fontana, G., Ideo, G., Manenti, F., Marenco, G., Morettini, A., Palasciano, G., Rossini, F. and Tittobello, A. (1988) Comparison of once-daily bedtime administration of famotidine and ranitidine in the short-time treatment of duodenal ulcer. A multicenter, double-blind, controlled study.Scand. J. Gastroenterol. 22:21.

    Google Scholar 

  102. Dohlman, H. G., Caron, M. G. and Lefkowitz, R. J. (1987) A family of receptors coupled to guanine nucleotide regulatory proteins.Biochem. 26:2657.

    Google Scholar 

  103. Dousa, T. P. and Code, C. F. (1974) Effect of histamine and its methyl derivatives on cyclic AMP metabolism in gastric mucosa and its blockade by an H2 receptor antagonist.J. Clin. Invest. 53:334.

    Google Scholar 

  104. Durant, G. J., Ganellin, C. R. and Parsons, M. E. (1975) Chemical differentiation of histamine H1- and H2-receptor agonists.J. Med. Chem. 18:905.

    Google Scholar 

  105. Ecknauer, R., Thompson, W. J., Johnson, L. R. and Rosenfeld, G. C. (1980) Isolated parietal cells: [3H] QNB binding to putative cholinergic receptors.Am. J. Physiol. 239:G204.

    Google Scholar 

  106. Eissele, R., Roßkopf, B., Koop, H., Adler, G. and Arnold, R. (1991) Proliferation of Endocrine Cells in the Rat Stomach Caused by Drug-Induced Achlorhydria.Gastroenterol. 101:70.

    Google Scholar 

  107. Ekblad, E., Ekelund, M., Graffner, H., Hakanson, R. and Sundler, F. (1985) Peptidecontaining nerve fibers in the stomach wall of rat and mouse.Gastroenterol. 89:73.

    Google Scholar 

  108. Ekman, L., Hansson, E., Havu, N., Carlsson, E. and Lundberg, C. (1985) Toxicological studies on omeprazole.Scand. J. Gastroenter. 20:53.

    Google Scholar 

  109. Ekman, R., Ivarsson, S. and Jansson, L. (1985) Bombesin, neurotensin and pro-γ-melanotropin immunoreactants in human milk.Regulatory Peptides 10:99.

    Google Scholar 

  110. Elouaer-Blanc, L., Sobhani, I., Ruszniewski, P., Duet, M., Lehy, T., Mignon, M., Bonfils, S. and Lewin, M. J. M. (1988) Gastrin secretion by gastrinoma cells in long-term culture.Am. J. Physiol. 255:G596.

    Google Scholar 

  111. Emami, S., Chastre, E., Bodéré, H., Gespach, C., Bataille, D., and Rosselin, G. (1986) Functional receptors for VIP, GIP, glucagon-29 and 37- in the HGT-1 human gastric cancer cell line.Peptides 7:121.

    Google Scholar 

  112. Emami, S., Chastre, E., Mulliez, N., Gonzales, M. and Gespach, C. (1986) VIP and histamine H2 receptor activity in human fetal gastric glands.Experientia 42:423.

    Google Scholar 

  113. Emami, S., Gespach, C. and Bodéré, H. (1985) Selective disappearance of histamine H2-receptor activity in the human gastric cell line HGT-1 after short-term or chronic treatment by histamine or its H2-antagonists.Agents and Actions 16:195.

    Google Scholar 

  114. Emami, S., Gespach, C., Forgue-Lafitte, M. E., Broer, Y. and Rosselin, G. (1983). Histamine and VIP interactions with receptor-cyclic AMP systems in the human gastric cancer cell line HGT-1.Life Sci. 33:415.

    Google Scholar 

  115. Emami, S. and Gespach, C. (1986) Desensitization by histamine of H2 receptor activity in HGT-1 human cancerous gastric cells.Agents and Actions 18:129.

    Google Scholar 

  116. Emami, S. and Gespach, C. (1986) Pharmacology of histamine H2 receptor antagonists in the human gastric cancer cell line HGT-1. Structure-activity relationship of isocytosine-furan and imidazole derivatives related to cimetidine.Biochem. Pharmac. 35:1825.

    Google Scholar 

  117. Emami, S., Mir, L., Gespach, C. and Rosselin, G. (1989) Transfection of fetal rat intestinal epithelial cells by viral oncogenes: Establishment and characterization of the E1A-immortalized SLC-11 cell line.Proc. Natl. Acad. Sci. USA.86:3194.

    Google Scholar 

  118. Emorine, L., Marullo, S., Briend-Sutren, M., Patey, G., YTate, K., Delavier-Klutchko, C. and Strosberg, A. D. (1989) Molecular characterization of the human β3 adrenergic receptor.Science 245:1118.

    Google Scholar 

  119. Euler, A. R., Bailey, R. J., Zinny, M. A., Brandon, M. L., Rousseau, B., Ferguson, J. P., Wood, D. R. and Le, V. H. (1989) Arbaprostil [15(R)-15-methyl prostagladin E2] in a single nighttime dose of either 50 or 100 mg in acute duodenal ulcer.Gastroenterology 97:98.

    Google Scholar 

  120. Evangelista, S., Lippe, I. T., Rovero, P., Maggi, C. A. and Meli, A. (1989) Tachykinin protect against ethanol-induced gastric lesions in rats.Peptides 10:79.

    Google Scholar 

  121. Fanning, J. C., Tyler, M. J. and Shearman, D. J. C. (1982) Converting a stomach to a uterus: The microscopic structure of the stomach of the gastric brooding frog rheobatrachus silus.Gastroenterol. 82:62.

    Google Scholar 

  122. Fedan, J. S., Hogaboom, G. K., Westfall, D. P. and O'Donnell, J. P. (1983) Photoaffinity labeling of P2-purinergic and H1-histamine receptors in intact smooth muscle.Feder. Proc. 42:2846.

    Google Scholar 

  123. Felder, C. C., Kanterman, R. Y., Ma, A. L. and Axelrod, J. (1989) A transfected M1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis.J. Biol. Chem. 264:20356.

    Google Scholar 

  124. Fernandez-Gallardo, S., Gijon, M. A., Garcia, M. del C., Cano, E. and Sanchez Crespo, M. (1988) Biosysthesis of platelet activating-factor in glandular gastric mucosa. Evidence for the involvement of the “de novo” pathway and modulation by fatty acids.Biochem. J. 254:707.

    Google Scholar 

  125. Ferrado, T., Rainero, I., De Gennaro, T., Ogerro, R., Mostert, M., Dottola, P. and Pinessi, L. (1990) β-endorphin-like and a-MSH-like immunoreactivities in human milk.Life Sci. 47:633.

    Google Scholar 

  126. Forgue-Laffitte, M. E., Kobari, L., Gespach, C., Chamblier, M. C. and Rosselin, G. (1984) Characterization and repartition of epidermal growth factor-urogastrone receptors in gastric glands isolated from young and adult guinea pigs.Biochim. Biophys. Acta 798:192.

    Google Scholar 

  127. Fraser, C. M. (1989) Site-directed mutagenesis of β-adrenergic receptors. Identification of conserved cysteine residues that independently affect ligand binding and receptor activation.J. Biol. Chem. 264:9266.

    Google Scholar 

  128. Fryklund, J. (1988) Specific labelling of gastric H+, K+-ATPase by omeprazole.Biochem. Pharm. 37:2543.

    Google Scholar 

  129. Frucht, H., Maton, P. N. and Jensen, R.T. (1991) Use of Omeprazole in Patients with Zollinger-Ellison Syndrome.Digestive Diseases and Sciences 36:394.

    Google Scholar 

  130. Fukui, H., Wang, N. P., Watanabe, T. and Wada, H. (1988) Solubilization, characterization and partial purification of [3H]mepyramine-binding protein, a possible histamine H1 receptor, from rat liver membrane.Jap. J. Pharmac. 46:127.

    Google Scholar 

  131. Funder, J. W. and Mercer, J. E. (1979) Cimetidine, a histamine H2 receptor antagonist, occupies androgen receptors.J. Clin. Endocrinol. Metab. 48:189.

    Google Scholar 

  132. Furchgott, R. F. (1983) Role of endothelium in responses of vascular smooth muscle.Circ. Res. 53:557.

    Google Scholar 

  133. Gajtkowski, G. A., Norris, D. B., Rising, T. J. and Wood, T. P. (1983). Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex.Nature 304:65.

    Google Scholar 

  134. Galbraith, R. A. and Jellinck, P. H. (1989) Differential effects of cimetidine, ranitidine and famotidine on the hepatic metabolism of estrogen and testosterone in male rats.Biochem. Pharmac. 38:2046.

    Google Scholar 

  135. Ganellin, C. R. (1985) A survey of recently described H2-receptor histamine antagonists. In: Frontiers in Histamine Research. A tribute to Heinz Schild. Advances in the Biosciences, 51, Ed Ganellin, C. R. and Schwartz, J. C. Pergamon Press Ltd, England, pp 47.

    Google Scholar 

  136. Gannon, B., Browning, J., O'Brien, P. and Rogers, P. (1984) Mucosal microvascular architecture of the fundus and body of human stomach.Gastroenterol. 86:866.

    Google Scholar 

  137. Gannon, B., Browning, J. and O'Brien, P. (1982) The microvascular architecture of the glandular mucosa of rat stomach.J. Anat. 135:667.

    Google Scholar 

  138. Gantz, I., Munzert, G., Tashiro, T., Schäffer, M., Wang, L., Del Valle, J. and Yamada, T. (1991). Molecular cloning of the human histamine H2 receptor.Biochem. Biophys. Res. Commun. 178:1386.

    Google Scholar 

  139. Gantz, I., Schäffer, M., Del Valle, J., Logsdon, C., Campbell, V., Uhler, M. and Yamada, T. (1991). Molecular cloning of a gene encoding the histamine H2 receptor.Proc. Natl. Acad. Sci. USA 88:429.

    Google Scholar 

  140. Gao, B. and Gilman, A. G. (1991) Cloning and expression of a widely distributed (type IV) adenylyl cyclase.Proc. Natl. Acad. Sci. USA 88:10178.

    Google Scholar 

  141. Garbers, D. L. (1989) Guanylate cyclase, a cell surface receptor.J. Biol. Chem. 264:9103.

    Google Scholar 

  142. Gespach, C., Abita, J. P. (1982). Human polymorphonuclear neutrophils. Pharmacological characterization of histamine receptors mediating the elevation of cyclic AMP.Molec. Pharmac. 21:78.

    Google Scholar 

  143. Gespach, C., Bataille, D., Dutrillaux, M. C. and Rosselin, G. (1982) The interaction of glucagon, gastric inhibitory peptide and somatostatin with cyclic AMP production systems present in rat gastric glands.Biochim. Biophys. Acta 720:7.

    Google Scholar 

  144. Gespach, C., Bawab, W., Chastre, E., Emami, S., Yanaihara, N. and Rosselin, G. (1988) Pharmacology and molecular identification of vasoactive intestinal peptide (VIP) receptors in normal and cancerous gastric mucosa in man.Biochem. Biophys. Res. Comm. 151:939.

    Google Scholar 

  145. Gespach, C., Bouhours D., Bouhours, J. F. and Rosselin, G. (1982) Histamine interaction on surface recognition sites of H2-type in parietal and non-parietal cells isolated from the guinea pig stomach.FEBS Lett. 149, 85.

    Google Scholar 

  146. Gespach, C., Chedeville, A., Hurbain-Kosmath, I., Housset, B., Derenne, J. P. and Abita, J. P. (1989) Adenylate cyclase activation by VIP-helodermin and histamine H2 receptors in human THP-1 monocytes/macrophages: A possible role in the regulation of superoxide anions production.Regulatory Peptides 26:158 (abstr.).

    Google Scholar 

  147. Gespach, C., Cherel, Y. and Rosselin, G. (1984) Development of sensitivity to cAMP-inducing hormones in the rat stomach.Am. J. Physiol. 247:G231.

    Google Scholar 

  148. Gespach, C., Dupont, C., Bataille, D. and Rosselin, G. (1980) Selective inhibition by somatostatin of cyclic AMP production in rat gastric glands. Demonstration of a direct effect on the parietal cell function.FEBS Lett. 114:247.

    Google Scholar 

  149. Gespach, C., Emami, S., Boige, N. and Rosselin, G. (1983) Chemical differentiation of histamine receptors coupled to cyclic AMP generation in human and guinea pig fundic glands. In Gut Peptides and Ulcer, Miyoshi, A., ed., Biomed. Res. Foundation, Tokyo, 55.

    Google Scholar 

  150. Gespach, C., Emami, S., Chastre, E., Launay, J. M. and Rosselin, G. (1987) Up-and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa.Biosci. Rep. 7:135–142.

    Google Scholar 

  151. Gespach, C., Emami, S. and Chastre, E. (1988) Membrane receptors in the gastrointestinal tract.Biosci. Rep. 8:199.

    Google Scholar 

  152. Gespach, C., Emami, S. and Rosselin, G. (1984) Gastric inhibitory peptide (GIP), pancreatic glucagon and vasoactive intestinal peptide (VIP) are cAMP-inducing hormones in the human gastric cancer cell line HGT-1. Homologous desensitization of VIP receptor activity.Biochem. Biophys. Res. Commun. 120:641.

    Google Scholar 

  153. Gespach, C., Fagot, D. and Emami, S. (1988) Pharmacological control of the human gastric histamine H2 receptor by famotidine: comparison with H1, H2 and H3 receptor agonists and antagonists.Eur. J. Clin. Invest. 19:1.

    Google Scholar 

  154. Gespach, C., Hansen, A. and Holst, J. (1989) Differential regulation of membrane receptors sensitive to histamine (H2-type), isoproterenol (β2-type) and glucagon-like peptides by the somatostatin analogue Sandostatin in rat gastric glands.Agents and Actions 27:169.

    Google Scholar 

  155. Gespach, C., Hui, Bon Hoa D. and Rosselin, G. (1983) Regulation by vasoactive intestinal peptide, histamine, somatostatin-14 and-28 of cyclic adenosine monophosphate levels in gastric glands isolated from the guinea pig fundus or antrum.Endocrinology 112:1597.

    Google Scholar 

  156. Gespach, C., Launay, J. M., Emami, S., Bondoux, D. and Dreux, C. (1986) Biochemical and pharmacological characterization of histamine-mediated up-regulation of human platelet serotonin uptake. Evidence for a subclass of histamine H2 receptors (H2h) highly sensitive to H2 receptor antagonists.Agents and Actions 18:115.

    Google Scholar 

  157. Gespach, C., Marrec, N. and Abita, J. P. (1986) Pharmacological characterization of the histamine uptake system in HL-60 human promyelocytic leukemia cells.Biosci. Rep. 6:403.

    Google Scholar 

  158. Gespach, C., Menez, I. and Emami, S. (1983) Potent and specific blockade by AH 22216 of histamine H2-receptor-mediated acid secretion in isolated rabbit gastric cells.Biosci. Rep. 3:871.

    Google Scholar 

  159. Gespach, C., Saal, F., Cost, H., and Abita, J. P. (1982) Identification and characterization of surface receptors for histamine in the human promyelocytic leukemia cell line HL-60.Molec. Pharmac. 22:547.

    Google Scholar 

  160. Gespach, C. (1986) Récepteurs H2 histaminergiques et peptidergiques de l'éptihélium gastrointestinal. Pharmacologie, fonction et développement. Thèse d'Etat, Université de Paris VII, volume I, 1.

    Google Scholar 

  161. Gitlin, N., McCullough, A. J., Smith, J. L., Mantell, G., Berman, R. and other members of the multicenter famotidine cooperative study group (1987) A mulilticenter, double-blind, randomized, placebo-controlled comparison of nocturnal and twice-a-day famotidine in the treatment of active duodenal ulcer disease.Gastroenterol. 92:48.

    Google Scholar 

  162. Goy, M. F. (1991) cGMP: The wayward child of the cyclic nucleotide family.TINS 14:293.

    Google Scholar 

  163. Grant, S. M., Langtry, H. D. and Brogden, R. N. (1989) Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.Drugs 37:801.

    Google Scholar 

  164. Green, J. P. and Maayani, S. (1977) Tricyclic antidepressant drugs block histamine H2 receptor in brain.Nature 269:163.

    Google Scholar 

  165. Gunion, M. W., Kauffman, G. L. and Taché, Y. (1990) Intrahypothalamic corticotropin-releasing factor elevates gastric bicarbonate and inhibits stress ulcers in rats.Am. J. Physiol. 258:G152.

    Google Scholar 

  166. Gutkind, J. S., Novotny, E. A., Brann, M. R. and Robbins, K. C. (1991) Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.Proc. Natl. Acad. Sci. USA 88:4703.

    Google Scholar 

  167. Halenda, S. P., Banga, H. S., Zavoico, G. B., Lau, L.-F. and Feinstein, M. B. (1989) Synergistic release of arachidonic acid from platelets by activators of protein kinase C and Ca2 + ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the Na+/H+ exchanger.Biochemistry 28:7356.

    Google Scholar 

  168. Hanks, S. K., Quinn, A. M. and Hunter, T. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.Science 241:42.

    Google Scholar 

  169. Hanneman, H. and Sewing, K. F. (1986) Ranitidine and famotidine differ in their interaction with the parietal cell histamine H2-receptor.Br. J. Pharmacol. 88:258P.

    Google Scholar 

  170. Hansen, A. B., Gespach, C., Rosselin, G. E. and Holst, J. J. Effect of truncated glucagon-like peptide 1 on cAMP in rat gastric glands and HGT-1 human gastric cancer cells.FEBS Lett. 236:119.

  171. Hansson, H.-A., Hong, L. and Helander, H. F. Changes in gastric EGF, EGF receptors and acidity during healing of gastric ulcer in the rat.Acta Physiol. Scand. 190 138:241.

  172. Harada, M. and Maeno, H. (1982) Effect of guanine nucleotides on histamine-sensitive adenylate cyclase from the parietal cells of guinea pig.Arch. Biochem. Biophys. 213:405.

    Google Scholar 

  173. Harada, M., Terai, M. and Maeno, H. (1983) Effect of a new potent H2-receptor antagonist 3[[[2-[(diaminomethylene)aminol]-4-thiazolyl]methyl]thio]-N2-sulfamolypropionamidine (YM-11170) on gastric mucosal histamine-sensitive adenylate cyclase from guinea pig.Biochem. Pharmacol. 32:1635.

    Google Scholar 

  174. Hartig, P. R. (1989) Molecular biology of 5-HT receptors.TIPS 10:64.

    Google Scholar 

  175. Harty, R. F., Van der Vijver, J. C. and McGuigan, J. E. (1977) Stimulation of gastrin secretion and synthesis in antral organ culture.J. Clin. Invest. 60:51.

    Google Scholar 

  176. Hatt, J. F. and Hanson, P. J. (1988) Inhibition of gastric acid secretion by epidermal growth factor. Effects on cyclic AMP and on prostaglandin production in rat isolated parietal cells.Biochem J. 255:789.

    Google Scholar 

  177. Hatt, J. F. and Hanson, P. J. (1989) Sites of action of protein kinase C on secretory activity in rat parietal cells.Am. J. Physiol. 256:G129.

    Google Scholar 

  178. Hausdorff W. P. and Sekura, R. D., Aguilera, G. and Catt, K. J. (1987) Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins.Endocrinology 120:1668.

    Google Scholar 

  179. Hayano, T., Sogawa, K., Ichihara, Y., Fujii-Kuriyama, Y. and Takahashi, K. (1988) Primary Structure of Human Pepsinogen C Gene.J. Biol. Chem. 263:1382.

    Google Scholar 

  180. Hediger, M. A., Coady, A. H., Ikeda, T. S. and Wright, E. M. (1987) Expression cloning and cDNA sequencing of the Na+/glucose co-transporter.Nature 330:379.

    Google Scholar 

  181. Heim, H. K., Oestmann, A. and Sewing, Fr. K. (1991) Effects of histamine and activators of the cyclic AMP system on protein synthesis in and release of high molecular weight glycoproteins from isolated gastric non-parietal cells.Br. J. Pharmacol. 104:526.

    Google Scholar 

  182. Hejblum, G., Gaili, P., Boissard, C., Astésano, A., Marie, J. C., Anteunis, A., Hui Bon Hoa, D. and Rosselin, G. (1988) Combined ultrastructural and biochemical study of cellular processing of vasoactive intestinal peptide and its receptors in human colonic carcinoma cells in culture.Canc. Res. 48:6201.

    Google Scholar 

  183. Hernandez, D. E. (1989) Neurobiology of brain-gut interactions. Implications for ulcer disease.Dig. Dis. Sci. 34:1809.

    Google Scholar 

  184. Hersey, S. J., Perez, A., Matheravidathu, S. and Sachs, G. (1989) Gastric H+−K+-ATPasein situ. Evidence for compartmentalization.Am. J. Physiol. 257:G539.

    Google Scholar 

  185. Hervatin, F., Arrang, J. M., Dubrasquet, M. and Lewin, M. J. M. (1989) Le récepteur histaminergique H3 inhibe la sécrétion acide gastrique stimulée par la pentagastrine.Gastroenterol. Clin. Biol. 13:A8.

    Google Scholar 

  186. Hervatin, F., Moreau, E., Ducroc, R., Garzon, B., Avril, P., Millet, P. and Geloso, J. P. (1987) Ontogeny of rat gastric H+−K+-ATPase activity.Am. J. Physiol. 252:G28.

    Google Scholar 

  187. Hildebrandt, J. D., Sekura, R. D., Codina, J., Iyengar, R., Manclark, C. R. and Birnbaumer, L. (1983) Stimulation and inhibition of adenylyl cyclase mediated by distinct regulatory proteins.Nature 302:706.

    Google Scholar 

  188. Hiraishi, H., Terano, A., Ota, S. I., Ivey, K. J. and Sugimoto, T. (1986) Effect of cimetidine on indomethacin-induced damage in cultured rat gastric mucosal cells. Comparison with prostaglandins.J. Lab. Clin. Med. 108:608.

    Google Scholar 

  189. Hirschowitz, B. I. and Molina, E. (1983) Effect of cimetidine on histamine-stimulated gastric acid and electrolytes in dogs.Am. J. Physiol. 244:G416.

    Google Scholar 

  190. Hocevar, B. A. and Fields, A. P. (1991) Selective translocation of β11-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.J. Biol. Chem. 266:28.

    Google Scholar 

  191. Holm-Rutili, L. and Obrink, K. J. (1985) Rat gastric microcirculationin vivo.Am. J. Physiol. 248:G741.

    Google Scholar 

  192. Holt, S. and Howden, C. W. (1991) Omeprazole. Overview and Opinion.Digestive Diseases and Sciences 36:385.

    Google Scholar 

  193. Holzer, P., Livingston, E. H., Saria, A. and Guth, P. H. (1991) Sensory neurons mediate protective vasodilatation in rat gastric mucosa.Am. J. Physiol. 260:G363.

    Google Scholar 

  194. Holzer, P., Pabst, M. A., Lippe, I. T., Peskar, B. M., Peskar, B. A., Livingston, E. H. and Guth, P. H. (1990) Afferent nerve-mediated protection against deep mucosal damage in the rat stomach.Gastroenterol. 98:838.

    Google Scholar 

  195. Honda, Z.-I., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamato, T. and Shimizu, T. (1991) Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung.Nature 349:342.

    Google Scholar 

  196. Horisberger, J. D., Jaunin, P., Reuben, M. A., Lasater, L. S., Chow, D. C., Forter, J. G., Sachs, G., Rossier, B. C. and Geering, K. (1991) The H, K-ATPase β-Subunit Can Act as a Surrogate for the β-Subunit of Na, K-pumps.J. Biol. Chem. 266:19131.

    Google Scholar 

  197. Howard, J. M., Chremos, A. N., Collen, M. J., McArthur, K. E., Cherner, J. A., Maton, P. N., Ciarleglio, C. A., Cornelius, M. J., Gardner, J. D. and Jensen, R. T. (1985) Famotidine, a new, potent, long-acting histamine H2-receptor antagonist: comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison syndrome.Gastroenterol. 88:1026.

    Google Scholar 

  198. Hsueh, W., Gonzalez-Crussi, F. and Arroyave, J. L. (1988) Sequential Release of Leukotrienes and Norepinephrine in Rat Bowel After Platelet-Activating Factor. A mechanism study of platelet-activating factor-induced bowel necrosis.Gastroenterol. 94:1412.

    Google Scholar 

  199. Ichinose, M., Stretton, C. D., Schwatrz, J. C. and Barnes, P. L. (1989) Histamine H3-receptors inhibit cholinergic neurotransmission in guinea pig airways.Br. J. Pharmac. 97:13.

    Google Scholar 

  200. Im, W. B., Blakeman, D. P., Mendlein, J. and Sachs, G. (1984) Inhibition of (H++K+)-ATPase and H+ accumulation in hog gastric membranes by trifluoperazine, verapamil and 8-(N,N-Diethylamino)octyl-3,4,5-Trimethoxybenzoate.Bioch. Biophys. Acta. 770:65.

    Google Scholar 

  201. Inokuchi, H., Kawai, K., Takeuchi, Y. and Sano, Y. (1984) Immunohistochemical study on the morphology of enterochromaffin cells in the human fundic mucosa.Cell Tiss. Res. 235:703.

    Google Scholar 

  202. Inui, T., Chiba, T., Okimura, Y., Morishita, T., Nakamura, A., Yamaguchi, A., Yamatani, T., Kadowaki, S., Chihara, K. and Fujita, T. (1989) Presence and release of calcitonin gene-related peptide in rat stomach.Life Sciences 45:1199.

    Google Scholar 

  203. Ishihara, T., Ishihara, Y., Hayano, T., Katsura, I., Sogawa, K., Fujii-Kuriyama, Y. and Takahahsi, K. (1989) Primary Structure and Transcriptional Regulation of Rat Pepsinogen C Gene.J. Biol. Chem. 254:10193.

    Google Scholar 

  204. Ishikawa, S. and Sperelakis, N. (1987) A novel class (H3) of histamine receptors on perivascular nerve terminals.Nature 327:158.

    Google Scholar 

  205. Ito, S. (1987) Functional gastric morphology. In Physiology of the Gastrointestinal Tract, 2nd Edition, Johnson, L. R., ed., Raven Press, New York817.

    Google Scholar 

  206. Jackson, T. R., Blair, L. A. C., Marshall, J., Goedert, M. and Hanley, M. R. (1988) The mas oncogene encodes an angiotension receptor.Nature 335:437.

    Google Scholar 

  207. Jahnsen, T., Hedin, L., Kidd, V. J., Beattie, W. G., Lohmann, S. M., Walter, U., Durica, J., Schulz, T. Z., Schiltz, E., Browner, M., Lawrence, C. B., Goldman, D., Ratoosh, S. L. and Richards, J. (1986) Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells.J. Biol. Chem. 261:12352.

    Google Scholar 

  208. Jefferys, D. B. and Vale, J. A. (1978) Cimetidine and bradycardia.The Lancet i:828.

  209. Jennewein, H. M. (1977) The effect of clonidine on gastric acid secretion in rats and dogs. Naunyn-Schmiedeberg's Arch.Pharmacol. 297:85.

    Google Scholar 

  210. Jensen, R. T., Collen, M. J., Pandol, S. J., Allende, H. D., Raufman, J. P., Bissonnette, B. M., Duncan, W. C., Durgin, P. L., Gillin, J. C. and Gardner, J. D. (1983) Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states.New Engl. J. Med. 308:883.

    Google Scholar 

  211. Johnson, W. S. and Miller, D. R. (1988) Ranitidine and bradycardia.Annals Internal Med. 108:493.

    Google Scholar 

  212. Jones, D. B., Howden, C. W., Burget, D. W., Silletti, C. and Hunt, R. H. (1988) Alteration of H2 receptor sensitivity in duodenal ulcer patients after maintenance treatment with an H2 receptor antagonist.Gut 29:890.

    Google Scholar 

  213. Jones, C. M., Toh, B. H., Pettitt, J. M., Martinelli, T. M., Humphris, D. C., Callaghan, J. M., Goldkorn, I., Mu, F. T. and Gleeson, P. A. (1991) Monoclonal antibodies specific for the core protein of the β-subunit of the gastric proton pump (H+/K+ ATPase). An autoantigen targetted in pernicious anaemia.Eur. J. Biochem. 197:49–59.

    Google Scholar 

  214. Kageyama, T., Tanabe, K. and Koiwai, O. (1990) Structure and Development of Rabbit Pepsinogens. stage-specific zymogens, nucleotide sequences of cDNAs, molecular evolution, and gene expression during development.J. Biol. Chem. 265:17031.

    Google Scholar 

  215. Kalinyak, K. A., Sawutz, D. G., Lampkin, B. C., Johnson, C. L. and Whitsett, J. A. (1985) Effects of dimaprit on growth and differentiation of human promyelocytic cell line, HL-60.Life Sciences 36:1909.

    Google Scholar 

  216. Kaplan, D. R., Morrison, D. K., Wong, G., McCormick, F. and Williams, L. T. (1990) PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex.Cell. 61:125.

    Google Scholar 

  217. Karnick, P. S., Monahan, S. J. and Wolfe, M. M. (1989) Inhibition of gastrin gene expression by somatostatin.J. Clin. Invest. 83:367.

    Google Scholar 

  218. Keeling, D. J., Fallowfield, C., Milliner, K. J., Tingley, S. K., Ife, R. J. and Underwood, A. H. (1985) Studies on the mechanism of action of omeprazole.Bioechem. Pharmacol. 34:2967.

    Google Scholar 

  219. Kikkawa, U., Kishimoto, A. and Nishizuka, Y. (1989)Annu. Rev. Biochem. 58:31–44.

    Google Scholar 

  220. Kirch, W., Halabi, A., Linde, M., Santos, S. R. and Ohnhaus, E. E. (1989) Negative effects of famotidine on cardiac performance assessed by noninvasive hemodynamic measurements.Gastroenterol. 96:1388.

    Google Scholar 

  221. Kirkegaard, P., Moddy, A. J., Holst, J. J., Loud, F. B., Olsen, P. S. and Christiansen, J. (1982) Glicentin inhibits gastric acid secretion in the rat.Nature 297:156.

    Google Scholar 

  222. Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G. and Lefkowitz, R. J. (1988) Chimeric α2-, β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.Science 240:1310.

    Google Scholar 

  223. Konturek, S. J., Bielanski, W., Konturek, J. W., Oleksy, J. and Yamazaki, J. (1989) Release and action of epidermal growth factor on gastric secretion in humans.Scand. J. Gastroenterol. 24:485.

    Google Scholar 

  224. Konturek, S. J., Bilski, J., Dembinski, A., Warzecha, A., Beck, G. and Jendralla, H. (1987) Effects of leukotrienes on gastric acid and alkaline secretions.Gastroenterol. 92:1209.

    Google Scholar 

  225. Korner, M., Bouthenet, M. L., Ganellin, C. R., Garbarg, M., Gros, C., Ife, R. J., Sales, N. and Schwartz, J. C. (1986) [125]iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea pig brain.Eur. J. Pharmac. 120:151.

    Google Scholar 

  226. Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W. J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R. and Gilman, A. G. (1989) Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.Science 244:1558.

    Google Scholar 

  227. Krupinski, J. (1991) The adenylyl cyclase family.Mol. Cell. Biochem. 104:73–79.

    Google Scholar 

  228. Kubota, H., Taguchi, Y., Tohyama, M., Matsuura, N., Shiosaka, S., Ishihara, T., Watanabe, T., Shiotani, Y. and Wada, H. (1984) Electron microscopic identification of histidine decarboxylase-containing endocrine cells of the rat gastric mucosa.Gastroenterol. 87:496.

    Google Scholar 

  229. Kuo, J., Andersson, R. G. G., Wise, B. C., Mackerlova, L., Solomousson, I., Brackett, N. L., Kotoh, N., Shoji, M. and Wrenn, R. W. (1980) Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin and trifluoperazine.Proc. Natl. Acad. Sci. USA 77:7039.

    Google Scholar 

  230. Laboisse, C. L., Augeron, C., Couturier-Turpin, M. H., Gespach, C., Cheret, A. M. and Potet, F. (1982) Characterization of a newly established human gastric cancer cell line HGT-1 bearing histamine H2-receptors.Cancer Res. 42:1541.

    Google Scholar 

  231. Lamprecht, S. A., Schwartz, B., Krugliak, P., Odes, H. S., Guberman, R., Krawiec, J. (1986) Role of cyclic GMP in gastrin secretion from rat antral mucosae in organ culture.J. Cyclic Nucl. & Prot. Phosphor. Res. 11:177.

    Google Scholar 

  232. Lane, G. P. and Speed, B. (1989) Agranulocytosis after ranitidine administration.Med. J. Aust. 150:595.

    Google Scholar 

  233. Langman, M. J. S. (1988) Effets des antagonistes histaminiques H2 sur le métabolisme des médicaments et sur le système endocrine. In: Contrôle de la sécreétion acide, Mignon, M., Galmiche, J. P., Ruszniewski, P., Pappo, M., John Libbey Eurotext, Paris, p. 141.

    Google Scholar 

  234. Larsson, H., Carlsson, E., Hakanson, R., Mattsson, H., Nilsson, G., Seensalu, R., Wallmark, B. and Sundler, F. (1988) Time-course of development and reversal of gastric endocrine cell hyperplasia after inhibition of acid secretion. Studies with omeprazole and ranitidine in intact and antrectomized rats.Gastroenterol. 95:1477.

    Google Scholar 

  235. Larsson, H., Carlsson, E., Junggren, U., Olbe, L., Sjöstrand, S. E., Skanberg, I. and Sundell, G. (1983) Inhibition of Gastric Acid Secretion by Omeprazole in the Dog and Rat.Gastroenterol. 85:900.

    Google Scholar 

  236. Lechleiter, J., Girard, S., Glapham, D. and Peralta, E. (1991) Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors.Nature 350:505.

    Google Scholar 

  237. Lee, D. C., Carmichael, D. F., Krebs, E. G. and McKnight GS (1983) Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase.Proc. Natl. Acad. Sci. USA 80:3608.

    Google Scholar 

  238. Lee, E. R. and Leblond, C. P. (1985) Dynamic histology of the antral epithelium in the mouse stomach. II Ultrastructure and renewal of isthmal cells.Am. J. Anat. 172:205.

    Google Scholar 

  239. Lee, Er and Leblond, C. P. (1985) Dynamic histology of the antral epithelium in the mouse stomach. IV Ultrastructural and renewal of gland cells.Am. J. Anat.,172, 241.

    Google Scholar 

  240. Lee, E. R. (1985) Dynamic histology of the antral epithelium in the mouse stomach. I Architecture of antral units.Am. J. Anat. 172:187.

    Google Scholar 

  241. Lee, E. R. (1985) Dynamic histology of the antral epithelium in the mouse stomach. III Ultrastructure and renewal of pit cells.Am. J. Anat. 172:225.

    Google Scholar 

  242. Lehy, T., Mignon, M., Cadiot, G., Elouar-Blanc, L., Ruszniewski, P., Lewin, M. J. M. and Bonfils, S. (1989) Gastric endocrine cell behavior in Zollinger-Ellison patients upon long-term potent antisecretory treatment.Gastroenterol. 96:1029.

    Google Scholar 

  243. Lenz, H. J., Forquignon, I., Drüge, G. and Greten, H. (1989) Effects of neuropeptides on gastric acid and duodenal bicarbonate secretions in freely moving rats.Regul. Peptides 24:293.

    Google Scholar 

  244. Leonard, A., Cuq, P., Magous, R. and Bali, J.-P. (1991) M3-subtype muscarinic receptor that controls intracellular calcium release and inositol phosphate accumulation in gastric parietal cells.Biochem. Pharmacol. 42:839.

    Google Scholar 

  245. Leth, R., Elander, B., Haglund, U., Olbe, L. and Fellenius, E. (1987) Histamine H2-receptor of human and rabbit parietal cells.Am. J. Physiol. 253:G497.

    Google Scholar 

  246. Leung, F. W. (1991) Role of blood flow and alcaline secretion in acid-induced deep duodenal villous injury in rats.Am. J. Physiol. 26:G399.

    Google Scholar 

  247. Leurs, R., Bast, A. and Timmerman, H. (1989) High affinity, saturable [3H]-mepyramine binding site on rat liver plasma membrane do not represent histamine H1-receptors. A warning.Biochem. Pharmac. 38:2175.

    Google Scholar 

  248. Levine, M. A., Smallwood, P. M., Moen, P. T., Helman, L. J. and Ahn, T. G. (1990) Molecular cloning of β3 subunit, a third form of the G protein β-subunit polypeptide.Proc. Natl. Acad. Sci. USA 87:2329.

    Google Scholar 

  249. Lewin, M. J. M. (1984) Oméprazole: un nouveau mécanisme d'action et une efficacité sans précédent dans le traitment de l'hypersécreétion acide gastrique.Gastroenterol. Clin. Biol. 8:939.

    Google Scholar 

  250. Lewin, M. J. M. (1985) La sécrétion acide de l'estomac: un mécanisme biologique peu connu.Médecine/Sciences. 85:234.

    Google Scholar 

  251. Lewis, J. H. (1987) Hepatic effects of drugs used in the treatment of peptic ulcer disease.Am J. Gastroenterol. 82:987.

    Google Scholar 

  252. Liang, T. (1984) Absence of androgen receptor affinity for MK-208, a new H2-receptor antagonist.Clin. Res. 32:283A.

    Google Scholar 

  253. Lips, D. L., Majerus, P. W., Gorga, F. R., Young, A. T. and Benjamin, T. L. (1989) Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II.J. Biol. Chem. 264:8759.

    Google Scholar 

  254. Lobie, P. E., Breipohl, W. and Waters, M. J. (1990) Growth Hormone Receptor Expression in the Rat Gastrointestinal Tract.Endocrinol. 126:299.

    Google Scholar 

  255. Lönroth, H., Hakanson, R., Lundell, L. and Sundler, F. (1990) Histamine containing endocrine cells in the human stomach.Gut 31:383.

    Google Scholar 

  256. Lönroth, H., Lundell, L. and Rosengren, E. (1989) Histamine metabolism of the human gastric mucosa—a study on the regional distribution of the amine and enzyme activities.Scand. J. Clin. Lab. Invest. 49:23.

    Google Scholar 

  257. Lönroth, H., Rosengren, E., Olbe, L. and Lundell, L. (1990) Histamine metabolism in human gastric mucosa. Effect of pentagastrin stimulation.Gastroenterology 98:921.

    Google Scholar 

  258. Lorentzon, P., Eklundh, B., Brändström, A. and Wallmark, B. (1985) The mechanism for inhibition of gastric (H++K+)-ATPase by omeprazole.Biochem. Biophys. Acta. 817:25.

    Google Scholar 

  259. Lundell, L., Forssel, H., Lönroth, H., Rosengren, E., and Wingren, U. (1986) Histamine storage and formation in canine gastric mucosa. Effect of pentagastrin stimulation.Acta Physiol. Scand. 128:587.

    Google Scholar 

  260. Ma, J. Y., Song, Y. H., Sjöstrand, S. E., Rask, L. and Mardh, S. (1991) cDNA cloning of β-subunit of the human gastric H, K-ATPase.Biochem. Biophys. Research Comm. 180:39.

    Google Scholar 

  261. Machen, T. E., Rutten, M. J. and Ekblad, E. B. M. (1982) Histamine, cAMP and activation of piglet gastric mucosa.Am. J. Physiol. 242:G79.

    Google Scholar 

  262. Maeda, M., Oshiman, K. I., Tamura, S. and Futai, M. (1990) Human Gastric (H++K+)-ATPase Gene. Similarity to (Na+ +K+)-ATPase genes in exon/intron organization but difference in control region.J. Biol. Chem. 265:9027.

    Google Scholar 

  263. Maeda, M., Oshiman, K. I., Tamura, S., Kaya, S., Mahmood, S., Reuben, M. A., Lasater, L. S., Sachs, G. and Futai, M. (1991) The Rat H+/K+-ATPase β Subunit Gene and Recognition of Its Control Region by Gastric DNA Binding Protein.J. Biol. Chem. 266:21584.

    Google Scholar 

  264. Magous, R., Bali, J. P., Rossi, J. C. and Girard, J. P. (1983) Leukotrienes stimulate acid secretion from isolated gastric parietal cells.Biochem. Biophys. Res. Commun. 144:897.

    Google Scholar 

  265. Magous, R., Baudiere, B. and Bali, J. P. (1985) Muscarinic receptors in isolated gastric fundic mucosal cells.Biochem. Pharmac. 34:2269.

    Google Scholar 

  266. Magous, R., Galleyrand, J. C. and Bali, J. P. (1989) Common or distinct receptors for gastrin and cholecystokinin in gastric mucosa?Biochim. Biophys. Acta 1010:357–362.

    Google Scholar 

  267. Mahon, W. A. and Kolton, M. (1978) Hypotension after intravenous cimetidine.Lancet i:828.

    Google Scholar 

  268. Major, J. S. and Scholes, P. (1978) The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins.Agents and Actions 8:324.

    Google Scholar 

  269. Malbon, C. C., Mangano, T. J. and Watkins, D. C. (1985) Heart contains two substrates (M=40.000 and 41.000) for pertussis toxin-catalyzed ADP-ribosylation that copurify with Ns.Biochem. Biophys. Res. Commun. 128:809.

    Google Scholar 

  270. Mangeat, P., Gespach, C., Marchis-Mouren, G. and Rosselin, G. (1982) Differential effects of histamine, vasoactive intestinal polypeptide, prostaglandin E2 and somatostatin on cyclic AMP-dependent protein kinase activation in gastric glands isolated from the guinea pig fundus and antrum.Regul. Peptides 3:155.

    Google Scholar 

  271. Mangla, J. C. and Pereira, M. (1982) Tricyclic antidepressants in the treatment of peptic ulcer disease.Arch. Intern. Med. 142:273.

    Google Scholar 

  272. Mardh, S., Song, Y. H. and Wallmark, B. (1988) Effects of some antisecretory drugs on acid production, intracellular free Ca2+, and cyclic AMP production in isolated pig parietal cells.Scand. J. Gastroenter 23:977.

    Google Scholar 

  273. Mardh, S., Ma, J. Y., Song, Y. H., Aly, A. and Henriksson, K. (1991) Occurrence of autoantibodies against intrinsic factor, H, K-ATPase, and pepsingoen in atrophic gastritis and rheumatoid arthritis.Scand. J. Gastroenterol. 26:1089.

    Google Scholar 

  274. Marino, L., Muglia, B. H. and Yamada, T. (1990) H+−K+-ATPase and carbonic anhydrase II gene expression in the developing rat fundus.Am. J. Physiol. 259:G108.

    Google Scholar 

  275. Marks, I. N. (1989) Alteration of H2 receptor sensitivity in duodenal ulcer patients.Gut 30:701.

    Google Scholar 

  276. Marshall, I. (1984) Characterization and distribution of histamine H1- and H2-receptors in precapillary vessels.J. Cardovasc. Pharmac. 6:S587.

    Google Scholar 

  277. Martinson, E. A., Goldstein, D. and Brown, J. H. (1989) Muscarinic receptor activation of phosphatidylcholine hydrolysis.J. Biol. Chem. 264:14748.

    Google Scholar 

  278. Martin, F., Martin, M. S. and Lorcerie, B. (1988) Les antisécrétoires provoquent-ils des cancers gastriques? In: Contrôle de la sécrétion acide, Mignon, M., Galmiche, J. P., Ruszniewski, P. and Pappo, M., John Libbey Eurotext, Paris,119.

    Google Scholar 

  279. Martin, T. F. J., Lucas, D. O., Bajjalieh, S. M. and Kowalchyk, J. A. (1986) Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide Phosphodiesterase in permeable GH3 cells.J. Biol. Chem. 261:2918.

    Google Scholar 

  280. Maton, P. N., Lack, E. E., Collen, M. J., David, E., Gardner, J. D. and Jensen, R. T. (1990). The effect of Zollinger-Ellison syndrome and omeprazol therapy on gastric oxyntic endocrine cells.Gastroenterol. 99:943.

    Google Scholar 

  281. Matsuda, M., Aono, M., Moriga, M. and Okuma, M. (1991) Centrally administered NPY stimulated gastric acid and pepsin secretion by a vagally mediated mechanism.Regulatory Peptides 35:31.

    Google Scholar 

  282. Mattson, J. P., Väänänen, K., Wallmark, B. and Lorentzon, P. (1991) Omeprazole and bafilomycin, two proton pump inhibitors. Differentiation of their effects on gastric, kidney and bone H+-translocating ATPases.Biochim. Biophys. Acta 1065:261.

    Google Scholar 

  283. Matuoka, K., Tanaka, M., Mitsui, Y. and Murota, S. I. (1983) Cultured rabbit gastric epithelial cells producing prostaglandin 12.Gastroenterol. 84:498.

    Google Scholar 

  284. McArthur, K. E., Collen, M. J., Maton, P. N., Cherner, J. A., Howard, J. M., Ciarleglio, C. A., Cornelius, M. J., Jensen, R. T., and Gardner, J. D. (1985) Omeprazole. Effective, convenient therapy for Zollinger-Ellison syndrome.Gastroenterol. 88:939.

    Google Scholar 

  285. McNeil, J. J., Mihaly, G. W., Anderson, A., Marshall, A. W., Smallwood, R. A. and Louis, W. J. (1981) Pharmacokinetics of the H2-receptor antagonist ranitidine in man.Br. J. Clin. Pharmac. 12:411.

    Google Scholar 

  286. Meldolesi, J., Clementi, E., Fasolato, C., Zacchetti, D. and Pozzan, T. (1991) Ca2+ influx following receptor activation.TIPS 12:289.

    Google Scholar 

  287. Menez, I., Gespach, C., Emami, S. and Rosselin, G. (1983) Irreversible and specific inactivation by AH 22216 of histamine H2 receptors in the human gastric cancer cell line HGT-1.Biochem. Biophys. Res. Commun. 116:251.

    Google Scholar 

  288. Mercier, F., Reggio, H., Devilliers, G., Bataille, G. and Mangeat, P. (1989) Membranecytoskeleton dynamics in rat parietal cells: mobilization of actin and spectrin upon stimulation of gastric acid secretion.J. Cell Biol. 108:441.

    Google Scholar 

  289. Michelangeli, F., Ruiz, M. C., Fernandez, E. and Ciarrocchi, A. (1989) Role of Ca2+ in H+ transport by rabbit gastric glands studied with A23187 and BAPTA, an incorporated Ca2+ chelator.Biochim. Biophys. Acta 983:82.

    Google Scholar 

  290. Michelangeli, F., Ruiz, M. C., Rodriguez, C. L. and Pelacca, A. (1988) Somatostatin inhibition of secretagogue and forskolin-stimulated gastric acid secretion.Am. J. Physiol. 254:G531.

    Google Scholar 

  291. Miederer, S. E., Schepp, W., Dein, H. J. and Ruoff, H. J. (1986) Effect of glucagon on adenylate cyclase activity and acid production of isolated human parietal cells.Klin. Wochenschr 64:746.

    Google Scholar 

  292. Minakuchi, R., Takai, Y., Yu, B. and Nishizuka, Y. (1981) Widespread occurrence of calcium-activated, phospholipid dependent protein kinase in mammalian tissues.J. Biochem. (Tokyo) 89:1651.

    Google Scholar 

  293. Minocherhomjee, A. M., Shattuck, R. L. and Storm, D. R. (1988) Calmodulin-stimulated adenylate cyclases. In: Cohen, P. and Klee, C. B. (eds): Calmodulin. Elsevier Science Publishers, New York,249.

    Google Scholar 

  294. Miwa, T. and Miyoshi, A. (1987) Famotidine in the treatment of gastritis.Scand. J. Gastroenter 22:46.

    Google Scholar 

  295. Miyamoto, T., Itoh, M., Noguchi, Y. and Yokochi, K. (1992) Role of intracellular Ca2+ and the calmodulin messenger system in pepsinogen secretion from isolated rabbit gastric mucosa.Gut. 33:21.

    Google Scholar 

  296. Molloy, C. J., Bottaro, D. P., Fleming, T. P., Marshall, M. S., Gibbs, J. B. and Aaronson, S. A. (1989) PDGF induction of tyrosine phosphorylation of GTPase activating protein.Nature 342:711.

    Google Scholar 

  297. Mori, S., Morishita, Y., Sakai, K., Kurimoto, S., Okamoto, M., Kawamoto, T. and Kuroki, T. (1987) Electron microscopic evidence for epidermal growth factor receptor (EGF-R)-like immunoreactivity associated with the basolateral surface of gastric parietal cells.Acta Pathol. Jap. 37:1909.

    Google Scholar 

  298. Morri, M., Takata, H. and Takeguchi, N. (1989) Acid activation of omeprazole in isolated gastric vesicles, oxyntic cells, and gastric glands.Gastroenterol. 96:1453.

    Google Scholar 

  299. Morrison, D. K., Kaplan, D. R., Escobedo, J. A., Rapp, U. R., Roberts, T. M. and Williams, L. T. (1989) Direct activation of the serine/threonine kinase activity of Raf-1 through trysoine phosphorylation by the PDGF β-receptor.Cell. 58:649.

    Google Scholar 

  300. Murakami, S., Muramatsu, M., Aihara, H. and Otomo, S. (1991) Inhibition of gastric H+, K+-ATPase by the antiulcer agent, sofalcone Biochemical Pharmacology.42:1447.

    Google Scholar 

  301. Murayama, T., Kajiyama, Y. and Nomura, Y. (1990) Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.J. Biol. Chem. 265:4290.

    Google Scholar 

  302. Murayama, T. and Ui, M. (1985) Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts.J. Biol. Chem. 260:7226.

    Google Scholar 

  303. Nagata, H. and Guth, P. H. (1983) Effect of histamine on microvascular permeability in the rat stomach.Am. J. Physiol. 245:G201.

    Google Scholar 

  304. Nagata, H. and Guth, P. H. (1984) Effect of topical histamine on mucosal microvascular permeability and acid secretion in the rat stomach.Am. J. Physiol. 246:G654.

    Google Scholar 

  305. Nagaya, H., Satoh, H. and Maki, Y. (1990) Possible mechanism for the inhibition of acid formation by the proton pump inhibitor AG-1749 in isolated canine parietal cells.J. Pharmacol. Exp Therap. 252:1289.

    Google Scholar 

  306. Nakaya, N. and Tasaka, K. (1987) The influence of histamine on precursors of granulocytic leukocytes in murine bone marrow.Life Sci. 42:999.

    Google Scholar 

  307. Nandi, J., King, R. L., Kaplan, D. S. and Levine, R. A. (1990) Mechanisms of gastric proton pump inhibition by calcium channel antagonists.J. Pharmacol. Exp. Therap. 252:1102.

    Google Scholar 

  308. Neer, E. J. and Clapham, D. E. (1988) Roles of G protein subunits in transmembrane signalling.Nature 333:129.

    Google Scholar 

  309. Negulescu, P. A. and Machen, T. E. (1988) Intracellular Ca regulation during secretagogue stimulation of the parietal cell.Am. J. Physiol. 254:C130.

    Google Scholar 

  310. Negulescu, P. A., Reenstra, W. W. and Machen, T. E. (1989) Intracellular Ca requirements for stimulus-secretion coupling in parietal cell.Am. J. Physiol. 256:C241.

    Google Scholar 

  311. Niedel, J. E., Kuhn, L. J. and Vandenbark, G. R. (1983) Phorbol diester receptor copurifies with protein kinase C.Proc. Natl. Acad. Sci. USA 80:36.

    Google Scholar 

  312. Nishikawa, H., Taniguchi, T., Ninomiya, H., and Fujiwara, M. (1988) Nicotinic acetylcholine receptors in the rat stomach: I. (−)-[3H]nicotine binding.Eur. J. Pharmac. 146:97.

    Google Scholar 

  313. Nishizuka, Y. (1986) Studies and perspectives of protein kinase C.Science 233:305.

    Google Scholar 

  314. Nizankowska-Blaz, T., Abramowicz, T., Korczowski, R. and Rusin, J. (1988) Triiodothyronine and thyroxine in human, cow's and formula milk.Exp. Clin. Endocrinol. 91:116.

    Google Scholar 

  315. Nogami, M., Suko, M. and Miyamato, T. (1990) The effect of platelet-activating factor on [14C] aminopyrine uptake by isolated guinea pig parietal cells.Biochem. and Biophys. Res. Comm. 168:1047.

    Google Scholar 

  316. Okada, M., Ohmura, E., Kamiya, I., Murakami, H., Tsushima, T. and Shizume, K. (1991) Transforming growth factor (TGF)-α in human milk.Life Sci. 48:1151.

    Google Scholar 

  317. Okada, Y. and Ueda, S. (1984) Electrical membrane responses to secretagogues in parietal cells of the rat gastric mucosa in culture.J. Physiol. 354:109.

    Google Scholar 

  318. Okumura, T., Uehara, A., Kitamori, S., Takasugi, Y. and Namiki, M. (1991) Central basic fibroblast growth factor inhibits gastric ulcer formation in rats.Biochem. Biophys. Res. Commun. 177:809.

    Google Scholar 

  319. Okumura, T., Uehara, A., Tsuji, K., Taniguchi, Y., Kitamori, S., Shibata, Y., Okamura, K., Takasugi, Y. and Namiki, M. (1991) Central nervous system action of basic fibroblast growth factor: Inhibition of gastric acid and pepsin secretion.Biochem. Biophys. Res. Commun. 175:527.

    Google Scholar 

  320. Olsen, P. S., Kirkegaard, P., Poulsen, S. S. and Nexo, E. (1986) Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland.Regul. Peptides 15:37.

    Google Scholar 

  321. Orloff, S. L., Bunnett, N. W., Walsh, J. H. and Debas, H. T. (1992) Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanism in rats.Am. J. Physiol. 262:G165.

    Google Scholar 

  322. Osband, M. and McCaffrey, R. (1979) Solubilization, separation and partial characterization of histamine H1 and H2 receptors from calf thymocyte membranes.J. Biol. Chem. 254:9970.

    Google Scholar 

  323. Oshiman, K. I., Motojima, K., Mahmood, S., Shimada, A., Tamura, S., Maeda, M. and Futai, M. (1991) Control region and gastric specific transcription of the rat H+, K+-ATPase α subunit gene.FEBS Letters 281:250.

    Google Scholar 

  324. Ostrowski, J. and Bomsztyk, K. (1989) Interaction of signal transduction pathways in mediating acid secretion by rat parietal cells.Am. J. Physiol. 256:C873.

    Google Scholar 

  325. Parker, J., Daniel, L. W. and Waite, M. (1987) Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.J. Biol. Chem. 262:5385.

    Google Scholar 

  326. Pearce, P. and Funder, J. W. (1980) Histamine H2 receptor antagonist: radioreceptor assay for antiandrogen side-effects.Clin. Exp. Pharmacol. Physiol. 7:442.

    Google Scholar 

  327. Peden, N. R., Richards, D. A., Saunders, J. H. B. and Wormsley, K. G. (1979) Pharmacologically effective plasma concentrations of ranitidine.Lancet ii,199.

  328. Pendleton, R. G., Torchiana, M. L., Chung, C., Cook, P., Wiese, S. and Clineschmidt, B. V. (1983) Studies on MK-208 (YM-11170) a new, slowly dissociable H2-receptor antagonist.Arch. Int. Pharmac. Ther. 266:4.

    Google Scholar 

  329. Penston, J. G. and Wormsley, K. G. (1989) Histamine H2-receptor antagonists versus prostaglandins in the treatment of peptic ulcer disease.Drugs 37:391.

    Google Scholar 

  330. Peskar, B. M., Respondek, M., Müller, K. M. and Peskar, B. A. (1991) A role for nitric oxide in capsaicin-induced gastroprotection.Eur. J. Pharmacol. 198:133.

    Google Scholar 

  331. Pfeiffer, A., Rochlitz, H., Herz, A. and Paumgartner, G. (1988) Stimulation of acid secretion and phosphoinositol production by rat parietal cell muscarinic M2 receptors.Am. J. Physiol. 254:G622.

    Google Scholar 

  332. Postius, S., Ruoff, H. J. and Szelenyi, I. (1985) Prostaglandin formation by isolated gastric parietal and nonparietal cells of the rat.Br. J. Pharmac. 84:871.

    Google Scholar 

  333. Poynter, D., Pick, C. R., Harcourt, R. A., Selway, S. A. M., Ainge, G., Harman, I. W., Spurling, N. W., Fluck, P. A. and Cook, J. L. (1985) Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat.Gut 26:1284.

    Google Scholar 

  334. Premont, R. T. and Lyengar, R. (1990) Adenylyl cyclase and its regulation by Gs. In: Iyengar, R. and Birnbuamer, L. (eds): G proteins. Academic Press, New York, p. 147.

    Google Scholar 

  335. Prost, A., Emami, S. and Gespach, C. (1984) Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric cancer cell line HGT-1.FEBS Lett. 177:227.

    Google Scholar 

  336. Rabon, E., Gunther, R. D., Soumarmon, A., Bassilian, S., Lewin, M. and Sachs, G. (1985) Solubilization and reconstitution of the gastric H, K-ATPase.J. Biol. Chem. 260:10200.

    Google Scholar 

  337. Ramano, M., Razandi, M. and Ivey, K. J. (1989) Protection of gastric epithelial cell monolayers from a human cell line by omeprazolein vitro.Scand. J. Gastroenterol. 24:513.

    Google Scholar 

  338. Rangachari, P. K. (1992) Histamine: mercurial messenger in the gut.Am. J. Physiol. 262:G1.

    Google Scholar 

  339. Ray, T. K., Nandy, J., Pidhorodeckyj, N. and Meng-Ai, A. (1982) Polyamines are inhibitors of gastric acid secretion.Biochemistry 79:1448.

    Google Scholar 

  340. Read, M. A., Chick, P., Hardy, K. J. and Shulkes, A. (1992) Ontogeny of gastrin, somatostatin, and the H+/K+-ATPase in the ovine fetus.Endocrinology 130:1688.

    Google Scholar 

  341. Reenstra, W. W., Shortridge, B. and Forte, J. G. (1985) Inhibition of the gastric (H++K+)-ATPase by fenoctimine.Biochem. Pharmacol. 34:2331.

    Google Scholar 

  342. Regardh, C. G., Gabrielsson, M., Hoffman, K. J., Löfberg, I. and Skanberg, I. (1985) Pharmacokinetics and metabolism of omeprazole in animals and man—an overview.Scand. J. Gastroenterol. 20:79.

    Google Scholar 

  343. Rehfeldt, W., Hass, R. and Goppelt-Struebe, M. (1991) Characterization of phospholipase A2 in monocytic cell lines.Biochem. J. 276:631.

    Google Scholar 

  344. Reyl-Desmars, F., Le Roux, S., Linard, C., Benkouka, F. and Lewin, M. J. M. (1989) Purification jusqu'à apparente homogénéité du récepteur de la somatostatine de la lignée cellulaire humaine HGT-1 d'origine gastrique.C. R. Acad. Sci. Paris 308:251.

    Google Scholar 

  345. Reyl, F. J. and Lewin, M. J. M. (1981) Somatostatin is a potent activator of phosphoprotein phosphatases in the digestive tract.Biochim. Biophys Acta 675:297.

    Google Scholar 

  346. Reyl, F. J. and Lewin, M. J. M. (1982) Intracellular receptor for somatostatin in gastric mucosal cells: Decomposition and reconstitution of somatostatin-stimulated phosphoprotein phosphatases.Proc. Natl. Acad. Sci. USA 79:978.

    Google Scholar 

  347. Rhee, S. G., Suh, P.-G., Ryu, S. H. and Lee, S. Y. (1989) Studies of inositol phospholipid-specific phospholipase C.Science 244:546.

    Google Scholar 

  348. Rhee, S. G. (1991) Inositol phospholipid-specific phospholipase C: Interaction of the γ1 isoform with tyrosine kinase.TIBS 16:297.

    Google Scholar 

  349. Richards, M. H. (1991) Pharmacology and second messenger interactions of cloned muscarinic receptors.Biochem. Pharmacol. 42:1645.

    Google Scholar 

  350. Ries, R. K., Gilbert, D. A. and Katon, W. (1984) Tricyclic antidepressant therapy for peptic ulcer disease.Arch. Intern. Med. 144:556.

    Google Scholar 

  351. Roberts, L. J., Bloomgarden, Z. T., Marney, S. R., Rabin, D. and Oates, J. A. (1983) Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin.Gastroenterol. 84:272.

    Google Scholar 

  352. Roche, S., Bali, J.-P., Galleyrand, J.-C. and Magous, R. (1991) Characterization of a gastrin type receptor on rabbit gastric parietal cells using L365,260 and L364,718.Am. J. Physiol. 260:G182.

    Google Scholar 

  353. Roche, S., Bali, J.-P. and Magous, R. (1990) Involvement of a pertussis toxin-sensitive G protein in the action of gastrin on gastric parietal cells.Biochim. Biophys. Acta 1055:287.

    Google Scholar 

  354. Roche, S., Gusdinar, T., Bali, J.-P. and Magous, R. (1991) “Gastrin” and “CCK” receptors on histamine- and somatostatin-containing cells from rabbit fundic mucosa-I.Biochem. Pharmacol. 42:765.

    Google Scholar 

  355. Roche, S., Gusdinar, T., Bali, J.-P. and Magous, R. (1991) Biphasic kinetics of inositol 1,4,5-trisphosphate accumulation in gastrin-stimulated parietal cells.FEBS Letters 282:147.

    Google Scholar 

  356. Roche, S., Gusdinar, T., Bali, J.-P. and Magous, R. (1991) Relationship between inositol 1,4,5-trisphosphate mass level and (14C)aminopyrine uptake in gastrin-stimulated parietal cells.Mol. Cell. Endocrinol. 77:109.

    Google Scholar 

  357. Roche, S. and Magous, R. (1989) Gastrin and CCK-8 induce inositol 1,4,5-trisphosphate formation in rabbit gastric parietal cells.Biochim. Biophys. Acta 1014:313.

    Google Scholar 

  358. Rodbell, M. (1980) The role of hormone receptors and GTP-regulatory proteins in membrane transduction.Nature 284:17.

    Google Scholar 

  359. Rosselin, G., Boige, N., Dupont, C. and Gespach, C. (1983) Receptors coupled to the cyclic AMP system in human gastric epithelium. In Gut Peptides and Ulcer, Miyoshi, A. ed., Biomedical Research Foundation, p 38.

  360. Rosselin, G. (1989) Les récepteurs de surface des cellules épithéliales digestives.Ann. Endocrinol. 50:447.

    Google Scholar 

  361. Ruat, M., Körner, M., Garbarg, M., Gros, C., Schwartz, J. C., Tertiuk, W. and Ganellin, C. R. (1988) Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125]iodoazidophenpyramine, an irreversible specific photoaffinity probe.Proc. Natl. Acad. Sci. USA 85:2743.

    Google Scholar 

  362. Ruat, M., Traiffort, E., Arrang, J.-M., Leurs, R. and Schwartz, J.-C. (1991) Cloning and tissue expression of a rat histamine H2-receptor gene.Biochem. Biophys. Res. Commun. 179:1470.

    Google Scholar 

  363. Rubin, W. A. (1973) A fine structural characterization of the proliferated endocrine cells in atrophic gastric mucosa.Am. J. Pathol. 70:109.

    Google Scholar 

  364. Ruiz, M. C. and Michelangeli, F. (1986) Stimulation of oxyntic and histaminergic cells in gastric mucosa by gastrin C-terminal tetrapeptide.Am. J. Physiol. 251:G529.

    Google Scholar 

  365. Ruoff, H. J., Reutter, K. and Schepp, W. (1985) Histamine content and release of isolated rat gastric mucosal cells.Agents and Actions 16:202.

    Google Scholar 

  366. Rutten, M. J. and Machen, T. E. (1981) Histamine, cyclic AMP and activation events in piglet gastric mucosain vitro.Gastroenterol. 80:928.

    Google Scholar 

  367. Ryberg, B., Bishop, A. E., Bloom, S. R., Carlsson, E., Hakanson, R., Larsson, H., Mattsson, H., Polak, J. M. and Sundler, F. (1989) Omeprazole and ranitidine, antisecretagogues with different modes of action, are equally effective in causing hyperplasia of enterochromaffin-like cells in rat stomach.Regul. peptides 25:235.

    Google Scholar 

  368. Ryu, S. H., Suh, P.-G., Cho, K. S., Lee, K.-Y. and Rhee, S. G. (1987) Bovine brain cytosol contains three immunologically distinct forms of inositolphospholipid-specific phospholipase C.Proc. Natl. Acad. Sci. USA 84:6649.

    Google Scholar 

  369. Saccomani, G., Psarras, C. G., Smith, P. R., Kirk, K. L. and Shoemaker, R. L. (1991) Histamine-induced chloride channels in apical membrane of isolated rabbit parietal cells.Am. J. Physiol. 260:C1000.

    Google Scholar 

  370. Saigenji, K., Fukutomi, H. and Nakazawa, S. (1987) Famotidine; postmarketing clinical experience.Scand. J. Gastroenter. 22:34.

    Google Scholar 

  371. Saltiel, A. R. and Cuatrecasas, P. (1988) In search of a sound messenger for insulin.Am. J. Physiol. 255:C1.

    Google Scholar 

  372. Sanders, M. J., Amirian, D. A., Ayalon, A., and Soll, A. H. (1983) Regulation of pepsinogen release from canine chief cells in primary monolayer culture.Am. J. Physiol. 245:G641.

    Google Scholar 

  373. Sandvik, A. K., Waldum, H. L. (1991) CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion.Am. J. Physiol. 260:G925.

    Google Scholar 

  374. Seperas, E., Kauffman, G. and Taché, Y. (1991) Role of central prostaglandin E2 in the regulation of gastric acid secretion in the rat.Eur. J. Pharm. 209:1.

    Google Scholar 

  375. Savola, M., Savola, J.-M. and Puurunen, J. (1989) α2-adrenoceptor-mediated inhibition of gastric acid secretion by medetomidine is efficiently antagonized by atipamezole in rats.Arch. int. Pharmacodyn. 301:267.

    Google Scholar 

  376. Sax, M. J. (1987) Clincially important adverse effects and drug interactions with H2-receptor antagonists: An update.Pharmacotherapy 7:110S.

    Google Scholar 

  377. Saxena, S. P., Brandes, L. J., Becker, A. B., Simons, J. K., LaBella, F. S. and Gerrard, J. M. (1989) Histamine is an intracellular messenger mediating platelet aggregation.Science 243: 1596.

    Google Scholar 

  378. Scarpignato, C., Tramacere, R., and Zappia, L. (1987) Antisecretory and antiulcer effect of the H2-receptor antagonist famotidine in the rat: comparison with ranitidine.Br. J. Pharmac. 92:153.

    Google Scholar 

  379. Schenker, S., Dicke, J., Johnson, R. F., Mor, L. L. and Henderson, G. I. (1987) Human placental transport of cimetidine.J. Clin. Invest. 80:1428.

    Google Scholar 

  380. Schepp, W., Kath, D., Zimmerhackl, B., Schusdziarra, V. and Classen, M. (1989) Leukotrienes C4 and D4 potentiate acid production by isolated rat parietal cells.Gastroenterol. 97:1420.

    Google Scholar 

  381. Schepp, W., Miederer, S. E. and Ruoff, H. J. (1985) Effects of hormones (calcitonin, GIP) and pharmacological antagonists (ranitidine and famotidine) on isolated rat parietal cells.Regulatory Peptides 12:297.

    Google Scholar 

  382. Schepp, W. and Ruoff, H. J. (1984) Adenylate cyclase and H+ production of isolated rat parietal cells in response to glucagon and histamine.Eur. J. Pharmac. 98:9.

    Google Scholar 

  383. Schjoldager, B. T. G., Mortensen, P. E., Christiansen, J., Orskov, C. and Holst, J. J. (1989) GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans.Dig. Dis. Sci. 34:703.

    Google Scholar 

  384. Schmidtler, J., Schepp, W., Janczewska, I., Weigert, N., Fürlinger, C., Schusdziarra, V. and Classen, M. (1991) GLP-1-(7–36)amide,-(1–37), and-(1–36) amide: potent cAMP stimuli of rat parietal cell function.Am. J. Physiol. 260:G940.

    Google Scholar 

  385. Schnefel, S., Pröfrock, A., Hinsch, K.-D. and Schulz, I. (1990) Cholecystokinin activates Gi1-, Gi2-, Gi3- and several Gs-proteins in rat pancreatic acinar cells.Biochem. J. 269:483.

    Google Scholar 

  386. Scholes, P., Cooper, A., Major, J. J., Walters, M. and Wilde, C. (1976) Characterization of an adenylate cyclase system sensitive to histamine H2-receptor excitation in cells from dog gastric mucosa.Agents and Actions 6:677.

    Google Scholar 

  387. Schubert, M. L., Hightower, J. and Makhlouf, G. M. (1989) Linkage between somatostatin and acid secretion: evidence from use of pertussis toxin.Am. J. Physiol. 256:G418.

    Google Scholar 

  388. Schubert, M. L. (1991) The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin.Gastroenterol. 100:1195.

    Google Scholar 

  389. Schubert, M. L., Jong, M. J. and Makhlouf, G. M. (1991) Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the funduns.Am. J. Physiol. 261:G885.

    Google Scholar 

  390. Schulz, S., Chinkers, M. and Garbers, D. L. (1989) The guanylate cyclase/receptor family of proteins.FASEB J. 3:2026.

    Google Scholar 

  391. Schulz, S., Yuen, P. S. T. and Garbers, D. L. (1991) The expanding family of guanylyl cyclases.TIPS 12:116.

    Google Scholar 

  392. Schunack, W. (1987) What are the differences between the H2-receptor antagonists?Aliment. Pharmac. Therapy 1:493S.

    Google Scholar 

  393. Scott, J. B., Glaccum, M. B., Zoller, M. J., Uhler, M. D., Helfman, D. M., McKnight, G. S. and Krebs, E. G. (1987) The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.Proc. Natl. Acad. Sci. USA 84:5192.

    Google Scholar 

  394. Seamon, K. B. and Daly, J. W. (1981) Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.J. Biol. Chem. 256:9799.

    Google Scholar 

  395. Seidler, U., Beinborn, M. and Sewing, K. F. (1989) Inhibition of acid formation in rabbit parietal cells by prostaglandins is mediated by the prostaglandin E2 receptor.Gastroenterol. 96:314.

    Google Scholar 

  396. Sekiguchi, M., Sakakibara, K. and Fujii, G. (1978) Establishment of cultured cell lines derived from a human gastric carcinoma.Jap. J. Exp. Med. 48:61.

    Google Scholar 

  397. Sekiguchi, S., Nishioka, T., Kogure, M., Kusano, M., Horikoshi, T., Sugiyama, T. and Kobayashi, S. (1987) Once-daily administration of famotidine for reflux esophagitis.Scand. J. Gastroenter. 22:51.

    Google Scholar 

  398. Shah, G. V., Kacsoh, B., Seshardri, R., Grosvenor, C. E. and Crowley, W. R. (1989) Presence of calcitonin-like peptide in rat milk: Possible physiological role in regulation of neonatal prolactin secretion.Endocrinology 125:61.

    Google Scholar 

  399. Sharp, J. D., White, D. L., Chiou, G. X., Goodson, T., Gamboa, G. C., McClure, D., Burgett, S., Hoskins, J., Skatrud, P. L., Sportsman, J. R., Becker, G. W., Kang, L. H., Roberts, E. F. and Kramer, R. M. (1991) Molecular cloning and expression of human Ca2+-sensitive cytosolic phospholipase A2.J. Biol. Chem. 266:14850.

    Google Scholar 

  400. Shaw, G. P., Hatt, J. F., Anderson, N. G. and Hanson, P. J. (1987) Action of epidermal growth factor on acid secretion by rat isolated parietal cells.Biochem. J. 244:699.

    Google Scholar 

  401. Shepherd-Rose, A. J. and Pendleton, R. G. (1985) Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands.Eur. J. Pharmac. 106:423.

    Google Scholar 

  402. Shull, G. E. (1990) CDNA cloning of the β-subunit of the rat gastric H, K-ATPase.J. Biol. Chem. 265:12123.

    Google Scholar 

  403. Sigrist-Nelson, K., Krasso, A., Müller, R. K. M. and Fischli, A. E. (1987) Ro 18-5364, a potent new inhibitor of the gastric (H++K+)-ATPase.Eur. J. Biochem. 166:453.

    Google Scholar 

  404. Sinha, S. K. and Yunis, A. A. (1983) Isolation of colony stimulating factor from human milk.Biochem. Biophys. Res. Commun. 114:797.

    Google Scholar 

  405. Skoglund, M. L., Gerber, J. G., Murphy, R. C. and Nies, A. S. (1980) Prostaglandin production by intact isolated gastric parietal cells.Eur. J. Pharmac. 66:145.

    Google Scholar 

  406. Smith, C. D., Uhing, R. J. and Snyderman, R. (1987) Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.J. Biol. Chem. 262:6121.

    Google Scholar 

  407. Smith, J. L., Gamal, M. A., Chremos, A. N. and Graham, D. Y. (1985) Famotidine, a new H2-receptor antagonist. Effect on parietal, nonparietal, and pepsin secretion in man.Digestive Diseases and Sciences 30:308.

    Google Scholar 

  408. Solcia, E., Capella, C., Buffa, R., Frigerio, B. and Fiocca, R. (1980) Pathology of the Zollinger-Ellison syndrome.Prog. Surg. Pathol. 1:112.

    Google Scholar 

  409. Soll, A. H., Amirian, D. A., Thomas, L. P., Reedy, T. J. and Elashoff, J. D. (1984) Gastrin receptors on isolated canine parietal cells.J. Clin. Invest. 73:1434.

    Google Scholar 

  410. Soll, A. H., Toomey, M., Culp, D., Shanahan, F. and Beaven, M. A. (1988) Modulation of histamine release from canine fundic mucosal mast cells.Am. J. Physiol. 254:G40.

    Google Scholar 

  411. Soll, A. H. and Toomey, M. (1989) β-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells.Am. J. Physiol. 256:G727.

    Google Scholar 

  412. Soll, A. H. (1978) The actions of secretagogues on oxygen uptake by isolated mammalian epithelial cells.J. Clin. Invest. 61:370.

    Google Scholar 

  413. Soll, A. H. (1978) The interaction of histamine with gastrin and carbamylcholine on oxygen uptake by isolated mammalian parietal cells.J. Clin. Invest. 61:381.

    Google Scholar 

  414. Soumarmon, A., Abastado, M., Bonfils, S. and Lewin, M. J. M. (1980) Cl Transport in gastric microsomes.J. Biol. Chem. 255:11682.

    Google Scholar 

  415. Speir, G., Takeuchi, K., Peitsch, W. and Johnson, L. (1982) Mucosal gastrin receptor VII. Up- and down-regulation.Am. J. Physiol. 242:G243.

    Google Scholar 

  416. Stachura, J., Krause, W. J. and Ivey, K. J. (1981) Ultrastructure of endocrine-like cells in lamina propria of human gastric mucosa.Gut. 22:534.

    Google Scholar 

  417. Stein, R., Pinkas-Kramarski, R. and Sokolovsky, M. (1988) Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.The EMBO J. 7:3031.

    Google Scholar 

  418. Sternweis, P. C. and Robishaw, J. D. (1984) Isolation of two proteins with high affinity for guanine nucleotide from membranes of bovine brain.J. Biol. Chem. 259:13806.

    Google Scholar 

  419. Stewart, B., Wallmark, B. and Sachs, G. (1981) The interaction of H+ and K+ with the partial reactions of gastric (H++K+)-ATPase.J. Biol. Chem. 256:2682.

    Google Scholar 

  420. Strathmann, M. P. and Simon, M. I. (1991) Gα12 and Gα13 subunits define a fourth class of G protein α subunits.Proc. Natl. Acad. Sci. USA 88:5582.

    Google Scholar 

  421. Sugatani, J., Fujimura, K., Miwa, M., Mizuno, T., Sameshima, Y. and Saito, K. (1989) Occurrence of platelet-activating factor (PAF) in normal rat stomach and alteration of PAF level by water immersion stress.The FASEB Journal 3:65.

    Google Scholar 

  422. Sugden, B. (1989) An intricate route to immortality.Cell 57:5.

    Google Scholar 

  423. Sun, X. M. and Hsueh, W. Bowel (1988) Necrosis Induced by Tumor Necrosis Factor in Rats is Mediated by Platelet-activating Factor.J. Clin. Invest. 81:1328.

    Google Scholar 

  424. Taché, Y. (1987) Central nervous system regulation of gastric acid secretion. In Physiology of the Gastrointestinal Tract, Johnson, L. R. ed., Raven Press, New York, pp. 911.

    Google Scholar 

  425. Takagi, T., Takeda, M. and Maeno, H. (1982) Effect of a new potent H2-blocker on gastric secretion induced by histamine and food in conscious dogs.Arch. int. Pharmacodyn 256:49.

    Google Scholar 

  426. Takeyama, M., Kondo, K., Hayashi, Y. and Yajima, H. (1989) Enzyme immunoassay of gastrin releasing peptide (GRP)-like immunoreactivity in milk.Int. J. Peptide Protein Res. 34:70.

    Google Scholar 

  427. Tang, W.-J., Krupinski, J. and Gilman, A. G. (1991) Expression and characterization of calmodulin-activated (type II) adenylylcyclase.J. Biol. Chem. 266:8595.

    Google Scholar 

  428. Tang, W.-J. and Gilman, A. G. (1991) Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ subunits.Science 254:1500.

    Google Scholar 

  429. Tanner, L. A. and Arrowsmith, J. B. (1988) Bradycardia and H2 antagonists.Ann. Int. Med., Sept.434.

  430. Taylor, K. M. (1973) Comparison of the antihistamien effect of burimamide and mepyramide and their effect on the activity of histamine methyltransferase.Biochem. Pharmacol. 22:2775.

    Google Scholar 

  431. Thompson, W. J., Chang, L. K. and Rosenfeld, G. C. (1981) Histamine regulation of adenylyl cyclase of enriched rat gastric parietal cells.Am. J. Physiol. 240:G76-G84.

    Google Scholar 

  432. Thompson, N. T., Bonser, R. W. and Garland, L. G. (1991) Receptor-coupled phospholipase D and its inhibition.TIPS 12:404.

    Google Scholar 

  433. Thurston, A. W., Cole, J. A., Hilmann, L. S., Im, J. H., Thorne, P. K., Krause, W. J., Jones, J. R., Eber, S. L. and Forte, L. R. (1990) Purification and properties of parathyroid hormone-related peptide isolated from milk.Endocrinology 126:1183.

    Google Scholar 

  434. Tielemans, Y., Hakanson, R., Sundler, F. and Willems, G. (1989) Prolififeration of enterochromaffinlike cells in omeprazole-treated hypergastrinemic rats.Gastroenterol. 96:723.

    Google Scholar 

  435. Toh, B. H., Gleeson, P. A., Simpson, R. J., Moritz, R. L., Callaghan, J. M., Goldkorn, I., Jones, C. M., Martinelli, T. M., Mu, F. T., Humphris, D. C., Pettitt, J. M., Mori, Y., Masuda, T., Sobieszczuk, P., Weinstock, J., Mantamadiotis, T. and Baldwin, G. S. (1990) The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a β subunit of the gastric H+/K+-ATPase (proton pump).Proc. Natl. Acad. Sci. USA 87:6418.

    Google Scholar 

  436. Topiol, S. and Sabio, M. (1991) The computational design of test compounds with potentially specific biological activity: Histamine-H2 agonists derived from 5-HT/H2 antagonists.Journal of Computer-Aided Molecular Design 5:263.

    Google Scholar 

  437. Torchiana, M. L., Pendleton, R. G., Cook, P. G., Hanson, C. A. and Clineschmidt, B. V. (1983) Apparent irreversible H2-receptor blocking and prolonged gastric antisecretory activities of 3-N-{3-[3-(1-piperidino-methyl)phonexy]propyl}amino-4-amino-1,2,5-thiodiazole-1-oxide (1-643,441).J. Pharmac. Exp. Therap. 224:514.

    Google Scholar 

  438. Trzeciakowski, J. P. (1987) Inhibition of guinea pig ileum contractions mediated by a class of histamine receptor resembling the H3 subtype.J. Pharmac. Exp, Therap. 243:874.

    Google Scholar 

  439. Tsai, B. S. and Yellin, T. O. (1984) Differences in the interaction of histamine H2 receptor antagonists and tricyclic antidepressants with adenylate cyclase from guinea pig gastric mucosa.Biochem. Pharmac. 33:3621.

    Google Scholar 

  440. Uhing, J. R., Prpic, V., Jiang, H. and Exton, J. H. (1986) Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes.J. Biol. Chem. 261:2140.

    Google Scholar 

  441. Ullrich, A. and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity.Cell 61:203.

    Google Scholar 

  442. Urushidani, T., Hanzel, D. K. and Forte, J. G. (1989) Characterization of an 80-kDa phosphorprotein involved in parietal cell stimulation.Am. J. Physiol. 256:G1070.

    Google Scholar 

  443. Urushidani, T., Hanzel, D. K. and Forte, J. G. (1987) Protein phosphorylation associated with stimulation of rabbit gastric glands.Biochim. Biophys. Acta 930:209.

    Google Scholar 

  444. Vanhoutte, P. M. (1990) Endothelium-derived relaxing and contracting factors.Adv. Nephrol. 19:3.

    Google Scholar 

  445. Van Tran, T. and Snyder, S. H. (1981) Histidine decarboxylase. Purification from fetal rat liver, immunologic properties and histochemical localization in brain and stomach.J. Biol. Chem. 256:680.

    Google Scholar 

  446. Varticovski, L., Druker, B., Morrison, D., Cantley, L. and Roberts, T. (1989) The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol 3-kinase.Nature 342:699.

    Google Scholar 

  447. Vigna, S. R., Mantyh, C. R., Giraud, A. S., Soll, A. H., Walsh, J. H. and Mantyh, P. W. (1987) Localization of specific binding sites for bombesin in the canine gastrointestinal tract.Gastroenterol. 93:1287.

    Google Scholar 

  448. Vinayek, R., Amantea, M. A., Maton, P. N., Frucht, H., Gardmer, J. D. and Jensen, R. T. (1991) Pharmacokinetics of oral and intravenous omeprazole in patients with the Zollinger-Ellison syndrome.Gastroenterol. 101:138.

    Google Scholar 

  449. Vogelsanger, B., Godrey, P. D. and Brown, R. D. (1991) Rotational spectra of biomolecules: Histamine.J. Am. Chem. Soc. 113:7864.

    Google Scholar 

  450. Wakelam, M., Murphy, G., Hruby, V. and Houslay, M. (1986) Activation of two signal-transduction systems by glucagon.Nature 323:68.

    Google Scholar 

  451. Wallace, J. L., Cucala, M., Mugridge, K. and Parente, L. (1991) Secretagogue-specific effects of interleukin-1 on gastric acid secretion.Am. J. Physiol. 261:G559.

    Google Scholar 

  452. Wallmark, B., Sachs, G., Mardh, S. and Fellenius, E. (1983) Inhibition of gastric (H++K+)-ATPase by the substituted benzimidazole picoprazole.Biochim. Biophys Acta 728:31.

    Google Scholar 

  453. Wallmark, B., Jaresten, B. M., Larsson, H., Ryberg, B., Brändström, A. and Fellenius, E. (1983) Differentiation among inhibitory actions of omeprazole, cimetidine, and SCN on gastric acid secretion.Am. J. Physiol. 245:G64.

    Google Scholar 

  454. Wallmark, B., Brändström, A. and Larsson, H. (1984) Evidence for acid-induced transformation of omeprazole into an active inhibitor of (H++K+)-ATPase within the parietal cell.Biochim. Biophys. Acta. 778:549.

    Google Scholar 

  455. Warlow, R. S., White, R. and Bernard, C. C. A. (1986) Solubilization and characterization of a low-affinity histamine-binding site on human blood mononuclear cells.Molecular. Immunol. 23:393.

    Google Scholar 

  456. Warrander, S. E., Norris, D. B., Rising, T. J. and Wood, T. P. (1983)3H-cimetidine and the H2-receptor.Life Sci. 33:1119.

    Google Scholar 

  457. Watson, S. and Abbott, A. (1992) Receptor Nomenclature Supplement.TIPS 12:1.

    Google Scholar 

  458. Werner, H., Koch, Y., Fridkin, M., Fahrenkrug, J. and Goes, I. (1985) High levels of vasoactive intestinal peptide in human milk.Biochem. Biophys. Res. Commun. 133:228.

    Google Scholar 

  459. Whalin, M. E., Scammell, J. G., Strada, S. J. and Thompson, W. J. (1991) Phosphodiesterase II, the cGMP-activable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.Mol. Pharmacol. 39:711.

    Google Scholar 

  460. Whitman, M., Downes, C. P., Keeler, M., Keeler, T. and Cantley, L. (1988) Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.Nature 332:644.

    Google Scholar 

  461. Wiedenmann, B., Waldherr, R., Buhr, H., Hille, A., Rosa, P. and Huttner, W. B. (1988) Identification of gastroenteropancreatic neuroendocrine cells in normal and neoplastic human tissue with antibodies against synaptophysin, chromgranin A, secretogranin I (chromogranin B) and secretogranin II.Gastroenterol. 95:1364.

    Google Scholar 

  462. Williams, L. T. (1989) Signal transduction by the platelet-derived growth factor receptor.Science 243:1564.

    Google Scholar 

  463. Wilson, W. E., Lazarus, L. H. and Tomer, K. B. (1989) Bradykinin and kininogens in bovine milk.J. Biol. Chem. 264:17777.

    Google Scholar 

  464. Wollin, A., Barnes, L. D., Hui, Y. S. and Dousa, T. P. (1975) Activation of protein kinase in the guinea pig fundic gastric mucosa by histamine.Life Sci. 17:1303.

    Google Scholar 

  465. Wolosin, J. M. and Forte, J. G. (1984) Stimulation of oxyntic cell triggers K+ and Cl-conductances in apical H+-K+-ATPase membrane.Am. J. Physiol. 246:C537.

    Google Scholar 

  466. Wouters, W., Van Dun, J., Leysen, J. E. and Laduron, P. M. (1985) Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin.J. Biol. Chem. 260:8423.

    Google Scholar 

  467. Wright, M. S., Gautvik, V. T. and Gautvik, K. M. (1992) Cloning strategies for peptide hormone receptors.Acta Endocrinol. 126:97.

    Google Scholar 

  468. Yamada, T. (1987) Local regulatory actions of gastrointestinal peptides. InPhysiology of the Gastrointestinal Tract, Johnson, L. R., ed. Raven Press, New York, pp. 131.

    Google Scholar 

  469. Yamada, Y., Post, S. R., Wang, K., Tager, H. S., Bell, G. I. and Seino, S. (1992) Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.Proc. Natl. Acad. Sci. USA 89:251.

    Google Scholar 

  470. Yamashita, M., Fukui, H., Sugama, K., Horio, Y., Ito, S., Mizuguchi, H. and Wada, H. (1991) Expression cloning of a cDNA encoding the bovine histamine H1 receptor.Proc. Natl. Acad. Sci. USA 88:11515.

    Google Scholar 

  471. Yarden, Y. and Ullrich, A. (1988) Growth factor receptor tyrosine kinases.Annu. Rev. Biochem. 57:443.

    Google Scholar 

  472. Yokel, R. A. and Dickey, K. M. (1991) Mucosal injury and γ-irradiation produce persistent gastric ulcers in the rabbit.Gastroenterol. 100:1201.

    Google Scholar 

  473. Yokotani, K., Muramatsu, I. and Fujiwara, M. (1984) Alpha-1 and alpha-2 type adrenoceptors involved in the inhibitory effect of splanchnic nerves on parasympathetically stimulated gastric acid secretion in rats.J. Pharmacol. Exp. Ther. 299:305.

    Google Scholar 

  474. Yoshimasa, T., Sibley, D. R., Bouvier, M., Lefkowitz, R. J. and Caron, M. G. (1987) Cross-talk between cellular signalling pathways suggesting by phorbol-ester-induced adenylate cyclase phosphorylation.Nature 327:67.

    Google Scholar 

  475. Young, D., Waitches, G., Birchmeier, C., Fasano, O. and Wigler, M. (1986) Isolation and Characterization of a New Cellular Oncogene Encoding a Protein with multiple Potential Transmembrane Domains.Cell. 45:711.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mirossay, L., Di Gioia, Y., Chastre, E. et al. Pharmacological control of gastric acid secretion: Molecular and cellular aspects. Biosci Rep 12, 319–368 (1992). https://doi.org/10.1007/BF01121499

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01121499

Key Words

Navigation