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Sequence of ionophore conformational changes induced by a simulated membrane/water interface

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Bioscience Reports

Abstract

We demonstrate how the progressive passage through an interface simulated by a linear increase in dielectric constant may mediate a reversible transconformation of Na+/X337A (lasalocid A) from a cyclic to an extended structure, During the passage through the interface, the complex adopts progressively a more extended conformation favorable to the Na+ complexation or decomplexation at the interface.

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Authors and Affiliations

  1. Laboratoire de Chimie Physique des Macromolécules aux Interfaces, et Laboratoire de Médecine Expérimentale, CP 206/2, Université Libre de Bruxelles, 1050, Bruxelles, Belgique

    Robert Brasseur, Michel Deleers & Jean-Marie Ruysschaert

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  1. Robert Brasseur
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  2. Michel Deleers
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  3. Jean-Marie Ruysschaert
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Brasseur, R., Deleers, M. & Ruysschaert, JM. Sequence of ionophore conformational changes induced by a simulated membrane/water interface. Biosci Rep 4, 651–658 (1984). https://doi.org/10.1007/BF01121018

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  • DOI: https://doi.org/10.1007/BF01121018

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