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Interaction of antimalarial drugs with hemin

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Bioscience Reports

Abstract

Hemin (ferriprotoporphyrin IX) is shown to form complexes with the chloroquine class of antimalarial drugs. The Soret band of hemin becomes optically active upon the addition of chiral drugs. Results on the hemin-induced quenching of the fluorescence of chloroquine are consistent with the formation of a 2∶1 hemin:drug complex with a formation constant of 1.4×107 at 298 K. Also a direct comparison of the drug-treated and drug-free parasites themselves, by the noninvasive photoacoustic spectroscopic method, reveals an in vivo interaction between endogenous hemin and the added drug.

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References

  1. Chou AC, Chevli R & Fitch CD (1980) Biochemistry19, 1543–1549.

    Google Scholar 

  2. Fitch CD & Chevli R (1981) Antimicrob. Agents Chemother.10, 589–592.

    Google Scholar 

  3. Orjih AU, Banyal HS, Chevli R & Fitch CD (1981) Science214, 667–669.

    Google Scholar 

  4. Jearnpipatkul A, Govitrapong P, Yuthavong Y, Wilairat P & Panijpan B (1980) Experientia36, 1063–1064.

    Google Scholar 

  5. Jearnpipatkul A & Panijpan B (1980) Chem. Biol. Interactions33, 83–90.

    Google Scholar 

  6. Moreau S, Perly B & Biguet J (1982) Biochimie64, 1015–1025.

    Google Scholar 

  7. Blauer G & Ginsburg H (1982) Biochem. Intl.5, 519–523.

    Google Scholar 

  8. Blauer G (1983) Biochem. Intl.6, 777–782.

    Google Scholar 

  9. Yamada KA, & Sherman IW (1979) Exp. Parasitol.48, 61–74.

    Google Scholar 

  10. Sirawaraporn W, Panijpan B & Yuthavong Y (1982) Exp. Parasitol.54, 260–270.

    Google Scholar 

  11. Rosencwaig A (1980) in: Photoacoustics and Photoacoustic Spectroscopy, Wiley, New York.

    Google Scholar 

  12. Balasubramanian D & Mohan Rao Ch (1981) Photochem. Photobiol.34, 749–752.

    Google Scholar 

  13. Balasubramnian D & Mohan Rao Ch (1982) Current Science51, 111–117.

    Google Scholar 

  14. Moore TA (1983) Photochem. Photobiol. Revs.7, 187–221.

    Google Scholar 

  15. Balasubramanian D (1983) Biosci. Rep.3, 981–994.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Biochemistry Department, Faculty of Science, Mahidol University, 10400, Bangkok, Thailand

    B. Panijpan

  2. Centre for Cellular and Molecular Biology, R.R.L. Campus, 500 007, Hyderabad, India

    Ch. Mohan Rao & D. Balasubramanian

Authors
  1. B. Panijpan
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  2. Ch. Mohan Rao
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  3. D. Balasubramanian
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Panijpan, B., Mohan Rao, C. & Balasubramanian, D. Interaction of antimalarial drugs with hemin. Biosci Rep 3, 1113–1117 (1983). https://doi.org/10.1007/BF01120204

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  • DOI: https://doi.org/10.1007/BF01120204

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