Abstract
The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used — fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat. Preparations of ceils expressing Class I MHC antigens, for example highly purified preparations of rat erythrocytes or platelets or mouse L cells (H2k) transfected with the D locus Class I gene of the b haplotype, LDb-1 cells, were used to pretreat recipients prior to transplantation, The function of the allograft was monitored in order to assess any beneficial effects induced by Class I MHC antigens. The results obtained implicate Class I MHC as important in the induction of specific immunosuppression of vascularized allograft rejection.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Betuel H, Cantarovitch D, Robert F, Gebuhrer L & Traeger J (1985) Transplant. Proc., in press.
Billingham RE, Brent L & Medawar PB (1953) Nature172, 603.
Chapman JR, Fisher M, Carter NP, Ting A & Morris PJ (1986) Transplantation, in press.
Corry RJ, Winn HJ & Russel PS (1973) Transplant. Proc.5, 733.
d'Apice AJF (1984) in:Kidney Transplantation. Principles and Practice (Morris PJ, ed), p 239, Grune and Stratton.
Fabre JW & Morris PJ (1972) Transplantation14, 608.
Fabre JW, Lim SH & Morris PJ (1971) Aust. N.Z. J. Surgery41, 69.
Hanto DW & Simmons RL (1984) Progress in Transplantation1, 186.
Kahan B (1985) Progress in Transplantation1, 115.
Morris PJ (1984a) in:Kidney Transplantation. Principles and Practice (Morris PJ, ed), p 547, Grune and Stratton.
Morris PJ (1984b) in:Kidney Transplantation. Principles and Practice (Morris PJ, ed), p 261, Grune and Stratton.
Morris PJ (1984b) in:Kidney Transplantation. Principles and Practice (Morris PJ, ed), p 261, Grune and Stratton.
Ozato K & Sachs DH (1981) J. Immunol.126, 317.
Rubin RH & Tolkoff-Rubin NE (1984) Progress in Transplantation1, 89.
Snell GD, Cloudman AM, Tailor E & Douglas P (1946) J. Nat. Cancer Inst.6, 303.
Superina RA, Wood KJ & Morris PJ (1985) Transplant. Proc., in press.
Superina RA, Peugh WH, Wood KJ & Morris PJ (1986) Transplantation, in press.
Welsh KI, Burgos H & Batchelor JR (1977) Eur. J. Immunol.7, 267.
Wigler M, Sweet R, Sim GK, Wood B, Pellow A, Lacy E, Maniatis T, Silverstein S & Axel R (1979) Cell16, 777.
Wood KJ & Morris PJ (1985a) Transplant. Proc.17, 1135.
Wood KJ & Morris PJ (1985b) Transplant. Proc., in press.
Wood KJ, Evins J & Morris PJ (1985) Transplantation39, 56.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wood, K.J., Morris, P.J. Antigen-induced suppression: The role of Class I major histocompatibility antigens. Biosci Rep 5, 1007–1014 (1985). https://doi.org/10.1007/BF01119913
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01119913