Skip to main content
SpringerLink
Log in

Genes for the protein antigens of the tuberculosis and leprosy bacilli

  • Published:
Bioscience Reports

Abstract

The λgtl l expression vector permitted us to survey protein antigens ofMycobacterium leprae andMycobacterium tuberculosis expressed inEscherichia coll. Using monocional antibodies, recombinant clones were detected producing three major antigens ofM. tuberculosis and five major protein antigens ofM. leprae. These recombinant antigens produced inE. coli should prove useful for diagnosis, epidemiology and possibly the development of recombinant mycobacterial vaccines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bloom BR & Godal T (1983) Rev. Infect. Dis.5, 765–779.

    PubMed  Google Scholar 

  • Britton WJ, Hellquist L, Basten A & Raison RL, in press.

  • Clark-Curtiss JE, Jacobs WR, Docherty MA, Ritchie LR & Curtiss R (1985) J. Bact.161, 1093–1102.

    PubMed  Google Scholar 

  • Comstock GW (1982) in:Tuberculosis in Bacterial Infections in Humans: Epidemiology and Control (Evans AS & Feldman HA, eds), pp 605–632, Plenum, New York.

    Google Scholar 

  • Engers H et al. (1985) Infect & Immunity48, 603–605.

    Google Scholar 

  • Gillis RP & Buchanan TM (1982) Infect. Immun37, 172.

    PubMed  Google Scholar 

  • Hansen GA (1874) Nor. Mag. Laegevidensk4, 1–88.

    Google Scholar 

  • Ivanyi J, Morris JA & Keen M (1985) in:Monoclonal Antibodies Against Bacteria (Macario AJL & Macario EC, eds), Academic Press, New York, in press.

    Google Scholar 

  • Koch RA (1881) Dtsch. Med. Wochenschr.17, 101–102.

    Google Scholar 

  • Kolk AHJ, Minh L-H, Klatser PR, Eggelte TA, Kuijper S, deJonge S & von Leeuwen J (1984) Clin. Exp. Immunol.58, 511–521.

    PubMed  Google Scholar 

  • WHO Workshop on Monoclonal Antibodies toM. tuberculosis. Infect Immun., in press.

  • Young DB, Fohn MJ, Khanolkar SR & Buchanan TM (1985) Clin. Exp. Immunol., in press.

  • Young RA & Davis RW (1983a) Proc. Natl. Acad. Sci. U.S.A.80, 1194–1198.

    PubMed  Google Scholar 

  • Young RA & Davis RW (1983b) Science222, 778–782.

    PubMed  Google Scholar 

  • Young RA, Bloom BR, Grosskinsky CM, Ivanyi J, Thomas D & Davis RW (1985a) Proc. Natl. Acad. Sci. U.S.A.82, 2583–2587.

    PubMed  Google Scholar 

  • Young RA, Mehra V, Sweetser D, Buchanan T, Clark-Curtiss J, Davis RW & Bloom BR (1985b). Nature316, 450–452.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Albert Einstein College of Medicine, 10461, New York, N.Y., USA

    Barry R. Bloom & Vijay Mehra

  2. Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA

    Vijay Mehra & Richard A. Young

Authors
  1. Barry R. Bloom
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vijay Mehra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard A. Young
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bloom, B.R., Mehra, V. & Young, R.A. Genes for the protein antigens of the tuberculosis and leprosy bacilli. Biosci Rep 5, 839–845 (1985). https://doi.org/10.1007/BF01119895

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01119895

Keywords

Search

Navigation