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The purine path to chemotherapy

  • Nobel Lecture
  • Published:
Bioscience Reports

Abstract

Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.

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Authors and Affiliations

  1. Wellcome Research Laboratories, Burroughs Wellcome Co, 3030 Cornwallis Road, 27709, Research Triangle Park, NC, USA

    Gertrude B. Elion

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  1. Gertrude B. Elion
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Nobel Lecture given on December 8, 1988; by Dr Gertrude B. Elion and published inLes Prix Nobel 1988, printed in Sweden by Norstedts Tryckeri, Stockholm, Sweden, 1989, republished here with the permission of the Nobel Foundation, the copyright holder.

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Elion, G.B. The purine path to chemotherapy. Biosci Rep 9, 509–529 (1989). https://doi.org/10.1007/BF01119794

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