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Aggregation and fusion of lipid vesicles induced by diphtheria toxin at low pH: Possible involvement of the P site and the NAD+ binding site

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Bioscience Reports

Abstract

Model membranes have been used to study the interaction between diphtheria toxin and lipids. We report here on the ability of this toxin to induc% at low pH, fusion and aggregation of asolectin lipid vesicles. Resonance energy transfer experiments using lipid fluorescent probes make it possible to discriminate between these two processes.

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Authors and Affiliations

  1. Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, Boulevard du Triomphe, CP 206/2, 1050, Bruxelles, Belgium

    Veronique Cabiaux, Michel Vandenbranden & Jean-Marie Ruysschaert

  2. Laboratoire de Chimie Biologique, Université de l'Etat à Mons, Avenue Maistraiau, 7000, Mons, Belgium

    Paul Falmagne

Authors
  1. Veronique Cabiaux
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  2. Michel Vandenbranden
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  3. Paul Falmagne
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  4. Jean-Marie Ruysschaert
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Cabiaux, V., Vandenbranden, M., Falmagne, P. et al. Aggregation and fusion of lipid vesicles induced by diphtheria toxin at low pH: Possible involvement of the P site and the NAD+ binding site. Biosci Rep 5, 243–250 (1985). https://doi.org/10.1007/BF01119594

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  • DOI: https://doi.org/10.1007/BF01119594

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