Abstract
Studies based on treatment with antibodies to thyrotropic hormone, luteotropic hormone, growth hormone or adrenocorticotropic hormone have shown that although the unicellular Tetrahymena does not possesssui generis receptors to all polypeptide hormones, such binding structures may arise, or become established in the membrane of the unicellular Tetrahymena in the presence of exogenous hormone. The Tetrahymena subjected to hormonal imprinting still contained an increased amount of hormone after six generation changes, which suggested that either hormone production had been induced by treatment, or the internalized hormone had not been degraded intracellularly. Thus the role of hormonal imprinting in receptor formation has also been substantiated by the immunocytochemical approach used in the present study.
This is a preview of subscription content, log in via an institution to check access.
References
Berelowitz, M., LeRoith, D., Von Schenk, H. Newgaard, C., Szabo, M., Frohman, L. A., Shiloach, J. and Roth, J. (1982)Endocrinology 110: 939–944.
Csaba, G. (1980)Biol. Rev. (Cambridge) 55:47–63.
Csaba, G. (1981)Ontogeny and phylogeny of hormone receptors. Karger, Basel, New York.
Csaba, G. (1985)Int. Rev. Cytol. 95:327–377.
Csaba, G. (1986)Experientia 42:715–718.
Csaba, G. Inczefi-Gonda, Á. and Fehér, T. (1985)Comp. Biochem. Physiol. 82A: 567–570.
Csaba, G., Darvas, Zs., Swydan, R. and Nagy, S. U. (1985)Experientia 41: 392–393.
Csaba, G. and Kovács, P. (1987)Z. Naturforsch. 42C:932–934.
Csaba, G. and Kovács, P. (1987)Cytobios. 52:17–22.
LeRoith, D., Liotta, A. S., Roth, J., Shiloach, J., Lewis, M. E., Pert, C. D. and Krieger, D. T. (1982)Proc. Natl. Acad. Sci. USA. 79:2086–2090.
LeRoith, D., Shiloach, J., Berelowitz, M., Frohman, L. A., Liotta, A. S., Krieger, D. T. and Roth, J. (1983)Fed. Proc. 42:2602–2607.
Mizihura, V., Yokofujita, J., Suzuki, H. and Sogiura, Y. (1986)Acta Histochem. Cytochem. 19:687–700.
Roth, J., LeRoith, D., Shiloach, J., Rosenzweig, H. L., Lesniak, M. A. and Havrankova, J. (1982)N. Engl. J. Med. 306:523–527.
Schwabe, C., LeRoith, D., Thompson, R. P., Shiloach, J. and Roth, J. (1983)J. Biol. Chem. 258;2778–2782.
Williams, N. E. (1983)J. Cell. Sci. 62:407–417.
Williams, N. E., Subbaiah, P. V. and Thompson, G. A. Jr. (1980)J. Biol. Chem. 255: 296–303.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kovács, P., Nozawa, Y. & Csaba, G. Induction of hormone receptor formation in the unicellular tetrahymena. Biosci Rep 9, 87–92 (1989). https://doi.org/10.1007/BF01117514
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01117514