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Extracellular adhesive molecules in neurite growth

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Bioscience Reports

Abstract

This review deals with two topics: (1) the effects of fibronectin and laminin on neurite growth and the molecular mechanisms of these effects, and (2) isolation and properties of the adhesive molecule p30. This novel molecule is an abundant heparin-binding protein in perinatal rat brain, and is suggested to have a role in neuronal growth.

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References

  • Arita, M., Tsuji, S., Omatsu, M. and Nagai Y. (1984). Studies on bioactive gangliosides: II Requirement of ganglioside GD1a for prolonged GQ1b-driven nerve growth promotion in neuroblastoma cell lines.J. Neurosci. Res. 12:289–297.

    Google Scholar 

  • Baron-Van Evercooren, A., Kleinman, H. K., Ohno, S., Marangos, P., Schwartz, J. P. and Dubois-Dalcq, M. E. (1982). Nerve growth factor, laminin and fibronectin promote neurite growth in human fetal sensory ganglia cultures.J. Neurosci. Res. 8: 179–194.

    Google Scholar 

  • Berg, D. K. (1984). New neuronal growth factors.Ann. Rev. Neurosci. 7: 149–170.

    Google Scholar 

  • Buck, C. A. and Horwitz, A. F. (1987). Cell surface receptors for extracellular matrix molecules.Ann. Rev. Cell Biol. 3:179–205.

    Google Scholar 

  • Carbonetto, S., Evans, D. and Cochard, P. (1987). Nerve fiber growth in culture on tissue substrata from central and peripheral nervous systems.J. Neurosci. 7: 610–620.

    Google Scholar 

  • Cheresh, D. A., Pierschbacher, M. D., Herzig, M. A. and Mujoo, K. (1986). Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins.J. Cell Biol. 102:688–696.

    Google Scholar 

  • Chiu, A. Y., Matthew, W. D. and Patterson, P. H. (1986). A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: Studies on the binding site and its localizationin vivo.J. Cell Biol. 103:1383–1398.

    Google Scholar 

  • Edgar, D., Timpl, R. and Thoenen, H. (1984). The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.EMBO J. 3:1463–1468.

    Google Scholar 

  • Engvall, E., Davis, G. E., Dickerson, K., Ruoslahti, E., Varon, S. and Manthorpe, M. (1986). Mapping of domains in human laminin using monoclonal antibodies: Localization of the neurite promoting site.J. Cell Biol. 103:2457–2465.

    Google Scholar 

  • Faivre-Bauman, A., Puymirat, J., Loudes, C., Barret, A. and Tixier-Vidal, A. (1984). Laminin promotes attachment and neurite elongation of fetal hypothalamic neurons grown in serum-free medium.Neurosci. Lett. 44:83–89.

    Google Scholar 

  • Graf, J., Iwamoto, Y., Sasaki, M., Martin, G. R., Kleinman, H. K., Robey, F. A. and Yamada, Y. (1987a). Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding.Cell 48:989–996.

    Google Scholar 

  • Graf, J., Ogle, R. C., Robey, F. A., Sasaki M, Martin, G. R., Yamada, Y. and Kleinman, H. K. (1987b). A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67 000 laminin receptor.Biochemistry 26: 6896–6900.

    Google Scholar 

  • Hakomori, S. (1981). Glycolipids in cellular interaction, differentiation, and oncogenesis.Ann. Rev. Biochem. 50:733–764.

    Google Scholar 

  • Hall, D. E., Neugebauer, K. M. and Reichardt, L. F. (1987). Embryonic neural retinal cell response to extracellular matrix proteins: developmental changes and effects of the cell substratum attachment antibody (CSAT).J. Cell Biol. 104:623–634.

    Google Scholar 

  • Hammarback, J. A., Palm, S. L., Furcht, L. T. and Letourneau, P. C. (1985). Guidance of neurite outgrowth by pathways of substratum-adsorbed laminin.J. Neurosci. Res. 13:213–220.

    Google Scholar 

  • Hynes, R. O. (1985). Molecular biology of fibronectin.Am. Rev. Cell Biol. 1:67–90.

    Google Scholar 

  • Hynes, R. O. (1987). Integrins: a family of cell surface receptors.Cell 48, 549–554.

    Google Scholar 

  • Jousimaa, J., Merenmies, J. and Rauvala, H. (1984). Neurite outgrowth of neuroblastoma cells induced by proteins covalently coupled to glass coverslips.Eur. J. Cell Biol. 35:55–61.

    Google Scholar 

  • Kennedy, D. W., Rohrbach, D. H., Martin, G. R., Momoi, T. and Yamada, K. M. (1983). The adhesive glycoprotein laminin is an agglutinin.J. Cell. Physiol. 114:257–262.

    Google Scholar 

  • Kleinman, H. K., Martin, G. R. and Fishman, P. H. (1979). Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.Proc. Natl. Acad. Sci. USA 76:3367–3371.

    Google Scholar 

  • Kleinman, H. K., Ogle, R. C., Cannon, F. B., Little, C. D., Sweeney, T. M. and Luckenbill-Edds, L. (1988). Laminin receptors for neurite formation.Proc. Natl. Acad. Sci. USA 85:1282–1286.

    Google Scholar 

  • Laitinen, J., Löppönen, R., Merenmies, J. and Rauvala, H. (1987). Binding of laminin to brain gangliosides and inhibition of laminin-neuron interaction by the gangliosides.FEBS Lett. 217:94–100.

    Google Scholar 

  • Lander, A. D., Fujii, D. K. and Reichardt, L. F. (1985). Laminin is associated with the “neurite outgrowth-promoting factors” found in conditioned media.Proc. Natl. Acad. Sci. USA 82:2183–2187.

    Google Scholar 

  • Ledeen, R. (1985). Gangliosides of the neuron.Trends in Neurosci. 8: 169–174.

    Google Scholar 

  • Lesot, H., Kuhl, U. and von der Mark, K. (1983). Isolation of a laminin-binding protein from muscle cell membranes.EMBO J. 2:861–865.

    Google Scholar 

  • Letourneau, P. C. (1983). Axonal growth and guidance.Trends in Neurosci. 6:451–455.

    Google Scholar 

  • Levi-Montalcini, R. (1987). The nerve growth factor: thirty-five years later.Biosci. Rep. 7:681–699.

    Google Scholar 

  • Liesi, P., Dahl, D. and Vaheri, A. (1983). Laminin is produced by early rat astrocytes in primary cultures.J. Cell Biol. 96:920–924.

    Google Scholar 

  • Malinoff, H. L. and Wicha, M. S. (1983). Isolation of a cell receptor protein for laminin from murine fibrosarcoma cells.J. Cell Biol. 96:1475–1479.

    Google Scholar 

  • Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F. M., Davis, G. E. and Varon, S. (1983). Laminin promotes neuritic regeneration from cultured peripheral and central neurons.J. Cell Biol. 97:1882–1890.

    Google Scholar 

  • Martin, G. R. and Timpl R. (1987). Laminin and other basement membrane components.Ann. Rev. Cell Biol. 3:57–85.

    Google Scholar 

  • Morgan, J. I. and Seifert, W. (1979). Growth factors and gangliosides: A possible new perspective in neuronal growth control.J. Supramolec. Struct. 10:111–124.

    Google Scholar 

  • Mähönen, Y. and Rauvala, H. (1985). Adhesive membrane protein of rat brain enhances neurite outgrowth of neuroblastoma cells.Eur. J. Cell Biol. 36:91–97.

    Google Scholar 

  • Pierschbacher, M. D. and Ruoslahti, E. (1984). Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.Nature 309:30–33.

    Google Scholar 

  • Pytela, R., Pierschbacher, M. D. and Ruoslahti, E. (1985). Identification and isolation of a 140 kD cell surface glycoprotein with properties expected of a fibronectin receptor.Cell 40:191–198.

    Google Scholar 

  • Rao, N. C., Barsky, S. H., Terranova, V. P. and Liotta, L. A. (1983). Isolation of a tumor cell laminin receptor.Biochem. Biophys. Res. Commun. 111:804–808.

    Google Scholar 

  • Rauvala, H. (1984). Neurite outgrowth of neuroblastoma cells: dependence on adhesion surface-cell surface interactions.J. Cell Biol. 98:1010–1016.

    Google Scholar 

  • Rauvala, H., Mähönen, Y., Jousimaa J., Merenmies, J., Lindholm, D. and Vuento M. (1987). Neurite outgrowth induced by adhesive proteins. In:Glial-Neuronal Communication in Development and Regeneration (H. H. Althaus and W. Seifert, Eds.), NATO ASI Series H, Vol. 2, Springer-Verlag, Berlin, Heidelberg, pp. 160–181.

    Google Scholar 

  • Rauvala, H. and Pihlaskari, R. (1987). Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons.J. Biol. Chem. 262:16625–16635.

    Google Scholar 

  • Roberts, D. D., Rao, C. N., Magnani, J. L., Spitalnik, S. L., Liotta, L. A. and Ginsburg, V. (1985). Laminin binds specifically to sulfated glycolipids.Proc. Natl. Acad. Sci. USA. 82: 1306–1310.

    Google Scholar 

  • Rogers, S. L., Letourneau, P. C., Palm, S. L., McCarthy, J. and Furcht, L. T. (1983). Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin.Dev. Biol. 98:212–220.

    Google Scholar 

  • Rogers, S. L., Letourneau, P. C., Peterson, B. A., Furcht, L. T. and McCarthy, J. B. (1987). Selective interaction of peripheral and central nervous system cells with two distinct cell-binding domains of fibronectin.J. Cell Biol. 105:1435–1442.

    Google Scholar 

  • Rovasio, R. A., Delouvee, A., Yamada, K. M., Timpl, R. and Thiery, J. P. (1983). Neural crest cell migration: requirements for exogenous fibronectin and high cell density.J. Cell Biol.,96:462–473.

    Google Scholar 

  • Ruoslahti, E. and Pierschbacher, M. D. (1987). New perspectives in cell adhesion: RGD and integrins.Science 238:491–497.

    Google Scholar 

  • Schubert, D., Humphreys, S., de Vitry, F. and Jacob, F. (1971). Induced differentiation of a neuroblastoma.Dev. Biol. 25:514–546.

    Google Scholar 

  • Seeds, N. W., Gilman, A. G., Amano, T. and Nirenberg, M. W. (1970). Regulation of axon formation by clonal lines of a neural tumor.Proc. Natl. Acad. Sci. USA 66:160–167.

    Google Scholar 

  • Smalheiser, N. R. and Schwartz, N. B. (1987). Cranin: a laminin-binding protein of cell membranes.Proc. Natl. Acad. Sci. USA 84:6457–6461.

    Google Scholar 

  • Thoenen, H. and Edgar, D. (1985). Neuronotrophic factors.Science 229:238–242.

    Google Scholar 

  • Thompson, L. K., Horowitz, P. M., Bentley, K. L., Thomas, D. D., Alderete, J. F. and Klebe, R. J. (1986). Localization of the ganglioside-binding site of fibronectin.J. Biol. Chem. 261: 5209–5214.

    Google Scholar 

  • Vanier, M. T., Holm, M., Öhman, R. and Svennerholm L. (1971). Developmental profiles of gangliosides in human and rat brain.J. Neurochem. 18:581–592.

    Google Scholar 

  • Wiegandt, H. (1982). The gangliosides.Adv. in Neurochem. 4:149–223.

    Google Scholar 

  • Yamada, K. M., Yamada, S. S. and Pastan, I. (1976). Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts.Proc. Natl. Acad. Sci. USA 73:1217–1221.

    Google Scholar 

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Authors and Affiliations

  1. University of Helsinki, Department of Medical Chemistry, Siltavuorenpenger 10A, 00170, Helsinki, Finland

    Heikki Rauvala, Riitta Pihlaskari, Jari Laitinen & Jussi Merenmies

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  1. Heikki Rauvala
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Rauvala, H., Pihlaskari, R., Laitinen, J. et al. Extracellular adhesive molecules in neurite growth. Biosci Rep 9, 1–12 (1989). https://doi.org/10.1007/BF01117507

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