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Control of tissue carnitine contents: Effects of partial hepatectomy and liver regeneration on carnitine concentrations in liver and extrahepatic tissues of the rat

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Bioscience Reports

Abstract

The liver is the sole site of carnitine biosynthesis in the rat. However, the first 24 h after the surgical removal of two-thirds of the liver mass are not associated with depletion of carnitine either in the liver remnant or in a number of extrahepatic tissues with relatively short turnover times of carnitine (<24 h; heart , spleen, kidney). Dietary carnitine was not supplied. The results suggest that the capacity of t h e remnant liver for carnitine biosynthesis is sufficient to maintain tissue carnitine contents. Liver regeneration influenced the relative proportions of hepatic free and acylated carnitines in a manner compatible with changes in fat disposition in the proliferating tissue.

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Authors and Affiliations

  1. The Surgical Unit, The London Hospital, Whitechapel, E1 1BB, London, UK

    Timothy J. French & Anthony W. Goode

  2. Department of Chemical Pathology, The London Hospital Medical College, Turner Street, E1 2AD, London, UK

    Paul S. Schofield & Mary C. Sugden

Authors
  1. Timothy J. French
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  2. Anthony W. Goode
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  3. Paul S. Schofield
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  4. Mary C. Sugden
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French, T.J., Goode, A.W., Schofield, P.S. et al. Control of tissue carnitine contents: Effects of partial hepatectomy and liver regeneration on carnitine concentrations in liver and extrahepatic tissues of the rat. Biosci Rep 5, 47–55 (1985). https://doi.org/10.1007/BF01117440

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  • DOI: https://doi.org/10.1007/BF01117440

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