Abstract
The carcinogenicity of several groups of carcinogens is evoked with particular reference to Dibenzo(c,g)carbazole derivatives. The activity of these derivatives is discussed with respect to their species and organ specificity. The enzymatic equipment is decisive as to whether the compounds formed can react with DNA or are simply detoxified and eliminated. All these carcinogens are complete carcinogens, i. e. they have the property of both initiation and promotion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Szafarz, D. and Weisburger, J. H. (1969) Stability of binding of label from N-hydroxy-N-2-fluorenylacetamide to intracellular targets, particularly deoxyribonucleic acid in rat liver.Cancer Research 29:962–968.
Bhargava, P. M., Szafarz, D., Bornecque, C. A. and Zajdela, F. (1976) A comparison of the ability of normal liver, a premalignant liver, a solid hepatoma and the Zajdela ascitic hepatoma, to take up amino acidsin vitro., J. Membrane Biol. 26:31–41.
Zajdela, F., Yoshikura, H. and Szafarz, D. (1976) DNA repair in cultured mouse cells induced by UV irradiation or polycyclic aromatic hydrocarbons; influence of caffeine. Colloques internationaux du CNRS, no 256, Cancérogénèse Chimique, 389–405. Menton, juillet 1976.
Jullien, P., Bornecque, D. and Szafarz, D. (1978) Effects of X irradiation of one or both partners on mammalian cell ability to form viable hybrids.Radiation Research 75:217–229.
Fiszer-Szafarz, B., Szafarz, D. and De Murillo, A. G. (1981) A general, fast, and sensitive micromethod for DNA determination: application to rat and mouse liver, rat hepatoma, human leukocytes, chicken fibroblasts, and yeast cells.Analytical Biochemistry 110:165–170.
Szafarz, D., Zajdela, F., Bornecque, C. and Barat, N. (1983) Evaluation of DNA crosslinks and monoadducts in mouse embryo fibroblasts after treatment with mono- and bifunctional furocoumarins and 365 nm (UVA) irradiation. Possible relationship to carcinogenicity.Photochemistry and Photobiology 38:557–562.
Szafarz, D. (1986) Formation by bifunctional furocoumarins of DNA crosslinks and their repair in cultured mouse embryo fibroblasts.Biochemistry International 13:735–739.
Périn, F., Dufour, M., Mispelter, J., Ekert, B., Künneke, C., Oesch, F. and Zajdela, F. (1981) Heterocyclic polycyclic aromatic hydrocarbon carcinogenesis: 7H-Dibenzo(c,g)carbazole metabolism by microsomal enzymes from mouse and rat liver.Chem. Biol. Interactions 35:267–284.
Valéro, D., Périn, F. and Zajdela, F. (1983) Binding of 5,9-dimethyl Dibenzo(c,g)carbazole, a potent hepatocarcinogen, to mouse hepatic cytosolic proteins.Carcinogenesis vol. 4, no 10, pp. 1333–1340.
Author information
Authors and Affiliations
Additional information
David Szafarz died while working on this manuscript (3 Sept. 1988). This paper, which has been edited by his widow Dr Berta Fiszer-Szafarz, is published in his memory. Some of David Szafarz's major contributions in this area are listed as references 1–7.
Rights and permissions
About this article
Cite this article
Szafarz, D., Périn, F., Valéro, D. et al. Structure and carcinogenicity of Dibenzo(c,g)carbazole derivatives. Biosci Rep 8, 633–643 (1988). https://doi.org/10.1007/BF01117342
Issue Date:
DOI: https://doi.org/10.1007/BF01117342