Skip to main content
SpringerLink
Log in

Regulation of cell division and malignant transformation

  • Published:
Bioscience Reports

Abstract

The problem of regulation of cell division is essentially a problem of understanding regulation of transition from the resting state of a cell to the dividing state and vice versa. In malignancy the ability to revert back to a normal resting state is impaired. A model is presented which attempts to explain the control of the above transitions through control of uptake of essential nutrients by a transport-inhibitory protein. Experimental evidence in favour of the model is given.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bhargava, P. M. (1977)J. Theor. Biol. 68:101–137.

    PubMed  Google Scholar 

  • Bhargava, P. M., Dwarakanath, V. N. and Prasad, K. S. N. (1978)Cellul. Mol. Biol. 25: 85–94.

    Google Scholar 

  • Bhargava, P. M. (1983)Curr. Sci. 52:199–205; 234–239.

    Google Scholar 

  • Bhargava, P. M. and Chandani, S. A. (1984)Symposia Biologica Hungarica 26:253–268.

    Google Scholar 

  • Bhargava, P. M. and Chandani, S. A. (1985)J. Biosci. (Proc. Int. Symp. Biomol. Struct. Interactions, (Suppl.)8:329–342.

    Google Scholar 

  • Bishop, J. M. (1985)Trends in Genet. 1:245–249.

    Google Scholar 

  • Chavrier, P., Zerial, M., Lemaire, P., Almendral, J., Bravo, R. and Charnay, P. (1988)EMBO J. 7:29–35.

    PubMed  Google Scholar 

  • Hanley, M. R. (1988)Neuron 1:175–182.

    PubMed  Google Scholar 

  • Ninomiya-Tsuiji, J., Ishibashi, S. and Ide, T. (1987)Cancer Res. 47:6028–6032.

    PubMed  Google Scholar 

  • Wynford-Thomas, D., Martin, G., La Montagne, A. and Prescott, D. M. (1985)Exp Cell. Res.158:276–279.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Cellular & Molecular Biology, 500 007, Hyderabad, India

    Pushpa M. Bhargava & Sushil A. Chandani

Authors
  1. Pushpa M. Bhargava
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sushil A. Chandani
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhargava, P.M., Chandani, S.A. Regulation of cell division and malignant transformation. Biosci Rep 8, 519–529 (1988). https://doi.org/10.1007/BF01117330

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01117330

Key Words

Search

Navigation