Abstract
In this study, the nucleotide sequences of the 3′ untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human β-actin genes were examined. It is shown (i) that the 3′ UTR of c-fos is highly conserved between mouse and man, (ii) that multiple copies of a 12 bp element occur, in clusters, in the 3′ UTR both of c-fos and of β-actin. This conserved 12 bp element is analogous to the putative repressor binding site previously identified (Renan,Bioscience Reports,5 (1985), 739–753). These findings provide additional support for the proposal that regulatory signals are located in the 3′ UTR's of certain genes.
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References
Caput, D., Beutler B., Hartog, K., Thayer, R., Brown-Shimer, S., and Cerami, A. (1986).Proc. Natl. Acad. Sci. USA 83:1670–1674.
Charnay, P., Treisman, R. Mellon, P., Chao, M., Axel, R., and Maniatis, T. (1984).Cell 38:251–263.
Curran, T., Peters, G., Van Beveren, C., Teich, N., and Verma, I. M. (1982).J. Virol. 44:674–682.
Emorine, L., Kuehl, M., Weir, L., Leder, P., and Max, E. E. (1983).Nature 304:447–449.
Greenberg, M. E., Hermanowski, A. L., and Ziff, E. B. (1986)Mol. Cell. Biol. 6:1932–2043.
Greenberg, M. E. and Ziff, E. B. (1984).Nature 312:711–716.
Hochschild, A. and Ptashne, M. (1986).Cell 44:681–687.
Meijlink, F., Curran, T., Miller, A. D., and Verma, I. D. (1985)Proc. Natl. Acad. Sci. USA 82:4987–4991.
Merrill, G. F., Hauschka, S. D., and McKnight, S. L. (1984).Mol. Cell. Biol 4:1777–1784.
Miyata, T., Yasunaga, T., and Nishida, T. (1980).Proc. Natl. Acad. Sci. USA,77 7328–7332.
Mous, J., Stunnenberg, H., Georgiev, O., and Birnstiel, M. (1985).Mol. Cell. Biol. 5:2764–2769.
Ng, S. Y., Gunning, P., Eddy, R., Ponte, P., Leavitt, J., Shows, T., and Kedes, L. (1985).Mol. Cell. Biol. 5:2720–2732.
Perler, F., Efstratiadis, A., LoMedico, P., Gibert, W., Kolodner, R., and Dodgson, J. (1980).Cell 20:555–566.
Ponte, P., Ng, S. Y., Engel, J., Gunning, P., and Kedes, L. (1984).Nucl. Acids Res. 12:1687–1696.
Queen, C. and Baltimore, D. (1983).Cell,33:741–748.
Renan, M. J. (1985).Biosci. Rep. 5:739–753.
Reudelhuber, T. (1984).Nature 312:700–701.
Romero-Herrera, A. E., Lehmann, H., Joysey, K. A., and Friday, A. E. (1983).Nature 246:389–395.
Sato, K., Ito, R., Baek, K. H., and Agarwal, K. (1986).Mol. Cell. Biol. 6: 1032–1043.
Treisman, R. (1985).Cell 42:889–902.
Van Beveren, C., Van Straaten, F., Curran, T., Müller, R., and Verma, I. M. (1983).Cell 32:1241–1255.
Van Straaten, F., Müller, R., Curran, T., Van Beveren, C., and Verma, I. M. (1983).Proc. Natl. Acad. Sci. USA 80:3183–3187.
Yaffe, D., Nudel, U., Mayer, Y., and Neuman, S. (1985).Nucl. Acids Res. 13: 3723–3737.
Yarger, J. G., Armilei, G., and Gorman, M. C. (1986).Mol. Cell. Biol. 6:1095–1101.
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Renan, M.J. Conserved elements in the 3′ untranslated regions of c-fos and actin mRNAs. Biosci Rep 6, 819–825 (1986). https://doi.org/10.1007/BF01117105
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DOI: https://doi.org/10.1007/BF01117105