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Evidence that fasting can induce a selective loss of uncoupling protein from brown adipose tissue mitochondria of mice

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Bioscience Reports

Abstract

The effects of fasting and refeeding on the concentration of uncoupling protein in brown adipose tissue mitochondria have been investigated in mice. Fasting mice for 48 h led to a large decrease in the total cytochrome oxidase activity of the interscapular brown fat pad. Mitochondrial GDP binding and the specific mitochondrial concentration of uncoupling protein also fell on fasting. After 24 h refeeding both GDP binding and the mitochondrial concentration of uncoupling protein were normalized, but there was no alteration in the total tissue cytochrome oxidase activity. Fasting appears to induce a selective loss of uncoupling protein from brown adipose tissue mitochondria, which is rapidly reversible on refeeding.

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Author notes

  1. P. Trayhurn

    Present address: Nutrition and Metabolism Research Group, University of Alberta, 3rd Floor, Newton Research Building, T6G 2C2, Edmonton, Alberta, Canada

Authors and Affiliations

  1. Dunn Nutrition Laboratory, Medical Research Council and University of Cambridge, Downham's Lane, Milton Road, CB4 1XJ, Cambridge, UK

    G. Jennings

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  1. P. Trayhurn
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Trayhurn, P., Jennings, G. Evidence that fasting can induce a selective loss of uncoupling protein from brown adipose tissue mitochondria of mice. Biosci Rep 6, 805–810 (1986). https://doi.org/10.1007/BF01117103

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  • DOI: https://doi.org/10.1007/BF01117103

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