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The effect of staphylococcal δ-haemolysin on the secretory activity of the pancreatic β-cell

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Bioscience Reports

Abstract

The secretion of insulin from isolated rat islets of Langerhans was found to be stimulated by the surface-active staphylococcal exotoxin, δ-haemolysin. The response was dependent on the concentration of δ-haemolysin, was rapid in onset, and could be maintained for at least an hour in the presence of the agent. The rate of secretion rapidly declined on removal of δ-haemolysin and the islets remained responsive to glucose follow!ng toxin treatment.

Further characterization of the interaction of this agent with the δ-cell plasma membrane may provide valuable information concerning the role played by this membrane in the regulation of insulin secretion.

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Authors and Affiliations

  1. Department of Biochemistry, University of Leicester, LE1 7RH, Leicester, UK

    Noel G. Morgan, Alexandra J. Fitzhugh & William Montague

Authors
  1. Noel G. Morgan
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  2. Alexandra J. Fitzhugh
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  3. William Montague
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Morgan, N.G., Fitzhugh, A.J. & Montague, W. The effect of staphylococcal δ-haemolysin on the secretory activity of the pancreatic β-cell. Biosci Rep 1, 135–140 (1981). https://doi.org/10.1007/BF01117010

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  • DOI: https://doi.org/10.1007/BF01117010

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